Patents by Inventor Robert V. Hageman

Robert V. Hageman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized FGF formulations containing reducing agents
    Patent number: 7754686
    Abstract: Stabilized FGF compositions are provided. The compositions comprise FGF or variant thereof and at least one reducing agent in an amount sufficient to inhibit FGF oxidation. Methods for increasing stability of FGF or variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: July 13, 2010
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Robert V. Hageman, Bret A. Shirley, Kamaljit K. Bajwa
  • Stabilized FGF formulations containing reducing agents
    Publication number: 20080293624
    Abstract: Stabilized FGF compositions are provided. The compositions comprise FGF or variant thereof and at least one reducing agent in an amount sufficient to inhibit FGF oxidation. Methods for increasing stability of FGF or variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.
    Type: Application
    Filed: August 31, 2001
    Publication date: November 27, 2008
    Inventors: Robert V. Hageman, Bret A. Shirley, Kamaljit K. Bajwa
  • Process for making L-phenyl acetyl carbinol (PAC), microorganisms for use in the process, and a method of preparing the microorganisms
    Patent number: 5312742
    Abstract: Mutations are induced in a microorganism selected from the species Saccharomyces cerevisiae or from the species Candida flareri. The resulting mutants are cultured in the presence of a fermentation inhibitor, such as acetaldehyde, ephedrine or PAC-dione, to form colonies having resistance to the inhibitor. Cells from the colonies are isolated and tested for yield of phenyl acetyl carbinol (PAC) in a fermentation with benzaldehyde and pyruvate. Yeast cells from the colonies that produce elevated levels of PAC are selected for use in subsequent fermentations. PAC is useful as an intermediate in the preparation of l-ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: May 17, 1994
    Assignee: Synergen Associates, Inc.
    Inventors: Robert J. Seely, Donald L. Heefner, Robert V. Hageman, Michael J. Yarus, Sally A. Sullivan
  • Process for preparing microorganisms used for making phenyl acetyl carlinol (PAC)
    Patent number: 5079145
    Abstract: Mutations are induced in a microorganism selected from the species Saccharomyces cerevisiae or from the species Candia flareri. The resulting mutants are cultured in the presence of a fermentation inhibitor, such as acetaldehyde, ephedrine or PAC-dione, to form colonies having resistance to the inhibitor. Cells from the colonies are isolated and tested for yield of phenyl acetyl carbinol (PAC) in a fermentation with benzaldehyde and pyruvate. Yeast cells from the colonies that produce elevated levels of PAC are selected for use in subsequent fermentations. PAC is useful as an intermediate in the preparation of 1-ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.
    Type: Grant
    Filed: October 21, 1988
    Date of Patent: January 7, 1992
    Assignee: Synergen Associates, Inc.
    Inventors: Robert J. Seely, Donald L. Heefner, Robert V. Hageman, Michael J. Yarus, Sally A. Sullivan