Patents by Inventor Robert V. O'Brien

Robert V. O'Brien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
    Patent number: 11950835
    Abstract: Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: April 9, 2024
    Assignees: Virginia Tech Intellectual Properties, Inc., AngioDynamics, Inc.
    Inventors: Timothy J. O'Brien, Robert E. Neal, II, Rafael V. Davalos
  • Efficient methods for Z- or cis-selective cross-metathesis
    Patent number: 8598400
    Abstract: The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: December 3, 2013
    Assignees: Massachusetts Institute of Technology, Trustees of Boston College
    Inventors: Amir H. Hoveyda, Simon J. Meek, Robert V. O'Brien, Josep Llaveria Cros, Richard R. Schrock
  • Efficient methods for Z- or cis-selective cross-metathesis
    Patent number: 8552242
    Abstract: The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: October 8, 2013
    Assignees: Massachusetts Institute of Technology, Trustees of Boston College
    Inventors: Amir H. Hoveyda, Simon J. Meek, Robert V. O'Brien, Josep Llaveria Cros, Richard R. Schrock
  • EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS
    Publication number: 20110245477
    Abstract: The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.
    Type: Application
    Filed: February 8, 2011
    Publication date: October 6, 2011
    Applicants: Trustees of Boston College, Massachusetts Institute of Technology
    Inventors: Amir H. Hoveyda, Simon J. Meek, Robert V. O'Brien, Josep Llaveria Cros, Richard R. Schrock