Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: The present disclosure is notably directed to a microfluidic probe head (202), or MFP head, comprising a processing surface (204) having liquid injection and liquid aspiration apertures, as well as projections (205) extending from the processing surface (204). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface (204) and a substrate (104) or sample surface (for example, the bottom of a microtiter plate sample well (102)), typically located beneath the processing surface (204). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

Abstract: A bag is formed of transparent polymeric material comprising a pair of side walls and a transverse weld forming a receptacle, and is characterized by a paper panel on the inner surface of one side wall, and a closure means comprising a plurality of strips of adhesive material, any one of which can join the other side wall to the paper panel in such a way that breaching of the adhesive material is evident by delaminating or tearing the panel.