Abstract: Described are assemblies for screening a compound for bioactivity, the assemblies comprising a tissue and a sensor. A change in a biological parameter is measured by the sensor, such that a change in a parameter occurring when the tissue is contacted with a candidate compound is detected by the sensor. Assemblies provided herein include single sensor/tissue assemblies and arrays of such assemblies, including plates comprising tissues in combination with one or more sensors. Also provided are methods of screening a compound using tissue/sensor tissue assemblies as described.

Abstract: A sleeve organized tissue is formed of a biocompatible structure surrounding organized tissue in at least one dimension and along a length of the tissue. In certain preferred embodiments the tissue is attached to the sleeve, subjecting the organized tissue to internal tension within the sleeve. Methods of providing organized tissue within a sleeve and delivering protein to a mammal are also disclosed.