Abstract: Methods and systems are disclosed for radiation therapy treatment planning. In one embodiment, a radiation therapy treatment planning method is disclosed for adjusting a dose distribution of a target anatomical portion. The method includes displaying an image of an implanted volume and a set of catheters displayed as implanted in the anatomical portion. The method also includes determining to adjust the dose distribution to the implanted volume for delivering via the catheters. The method also includes receiving, at a processor, a selection of a dose distribution parameter affecting the strength of the dose distribution and adjusting, based on the received parameter, a dwell weight of the radiation dose at each dose position in the set of catheters, wherein the adjusted dwell weight adjusts the dose distribution relative to a center region of the implanted volume for moving the distribution to or from an outer circumference of the target anatomical portion.