Abstract: Techniques regarding measuring a position and transcriptome of one or more cells from a biological sample are provided. For example, one or more embodiments described herein can comprise a method, which can comprise covalently bonding a probe to a molecular structure located on a cell to label the cell according to a position of the cell with regards to a biological sample comprising the cell. The probe comprises an oligonucleotide sequence that can be indicative of the position.

Abstract: Techniques regarding measuring a position and transcriptome of one or more cells from a biological sample are provided. For example, one or more embodiments described herein can comprise a method, which can comprise covalently bonding a probe to a molecular structure located on a cell to label the cell according to a position of the cell with regards to a biological sample comprising the cell. The probe comprises an oligonucleotide sequence that can be indicative of the position.

Abstract: A method of determining a charge of at least one test particle (as herein defined), comprising: applying one of an electric current or a voltage across an aperture connecting two chambers, whereby the chambers are at least partially filled with electrolyte and whereby the at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring a value indicative of the other of the electric current or voltage across the aperture; determining a time interval between a first and a second point in time, the second point in time corresponding to a point in time when the measured current or voltage has reached a specific proportion of the measured current or voltage at the first point in time; and determining the charge of the at least one test particle by: determining a value indicative of an electrical velocity component of a total velocity of at least one calibration particle having a known charge, taking into account that the total velocity of the at least one calibration particle

Abstract: A method of determining the charge of at least one test particle, comprising: applying one of an electric current or a voltage across an aperture connecting two chambers, whereby the chambers are at least partially filled with electrolyte and whereby the at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring the other of the electric current or voltage across the aperture; varying a pressure differential between the two chambers; and determining the charge based on the measurements of the electric current or voltage.

Abstract: A method of determining a charge of at least one test particle (as herein defined), comprising: applying one of an electric current or a voltage across an aperture connecting two chambers, whereby the chambers are at least partially filled with electrolyte and whereby the at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring a value indicative of the other of the electric current or voltage across the aperture; determining a time interval between a first and a second point in time, the second point in time corresponding to a point in time when the measured current or voltage has reached a specific proportion of the measured current or voltage at the first point in time; and determining the charge of the at least one test particle by: determining a value indicative of an electrical velocity component of a total velocity of at least one calibration particle having a known charge, taking into account that the total velocity of the at least one calibration particle

Abstract: A method of determining the charge of at least one test particle, comprising: applying one of an electric current or a voltage across an aperture connecting two chambers, whereby the chambers are at least partially filled with electrolyte and whereby the at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring the other of the electric current or voltage across the aperture; varying a pressure differential between the two chambers; and determining the charge based on the measurements of the electric current or voltage.

Abstract: A method of producing a film coated onto a substrate by dissolving a metal or metalloid containing compound having hydrolysable groups in a solvent to form a precursor solution. The precursor solution is coated onto the substrate as a continuous liquid phase. The precursor solution is then cured to produce a continuous, interconnected, nano-porous network.

Abstract: The present invention overcomes deficiencies in the prior art by providing a PIN-based system for managing delivery of privileged information, which utilizes “third-party” authorization. In one embodiment this system includes the use of three separate parties, a First Party, a Second Party, and a Third Party. The First Party initially “registers” with the Second Party by providing self-authenticating core registration information. This registration provides the First Party with a first set of privileges. The First Party may then ask for a PIN number in order to obtain a second set of privileges to observe information provided by the Second Party which is related to a Third Party. In requesting the PIN, the First Party must provide additional registration information (beyond the core information) to the Second Party relating to the Third Party, which the Second Party can authenticate due to an existing relationship which can be checked.

Abstract: A method of producing a film coated onto a substrate by dissolving a metal or metalloid containing compound having hydrolysable groups in a solvent to form a precursor solution. The precursor solution is coated onto the substrate as a continuous liquid phase. The precursor solution is then cured to produce a continuous, interconnected, nano-porous network.

Abstract: A method of producing a silica coating by forming a silica precursor formulation that is coated on a substrate as a continuous liquid phase. The silica precursor formulation is then cured in an ammoniacal atmosphere to produce a continuous, interconnected, nano-porous silica network.

Abstract: The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and modulating serotonin levels.

Abstract: This invention provides compounds of the formulae: wherein: R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms; R2 and R3 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl, alkoxy of 1-6 carbon atoms, —CH2OH, fluoroalkyl, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, aryl, or aroyl; R4 and R5 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, fluoroalkyl, —CN, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; R6 and R7 are each independently hydrogen, C1-C6 alkyl or cycloalkyl; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions containing thes

Abstract: The present invention overcomes deficiencies in the prior art by providing a PIN-based system for managing delivery of privileged information, which utilizes “third-party” authorization. In one embodiment this system includes the use of three separate parties, a First Party, a Second Party, and a Third Party. The First Party initially “registers” with the Second Party by providing self-authenticating core registration information. This registration provides the First Party with a first set of privileges. The First Party may then ask for a PIN number in order to obtain a second set of privileges to observe information provided by the Second Party which is related to a Third Party. In requesting the PIN, the First Party must provide additional registration information (beyond the core information) to the Second Party relating to the Third Party, which the Second Party can authenticate due to an existing relationship which can be checked.

Abstract: A method of producing a silica coating by forming a silica precursor formulation that is coated on a substrate as a continuous liquid phase. The silica precursor formulation is then cured in an ammoniacal atmosphere to produce a continuous, interconnected, nano-porous silica network.

Abstract: The present invention includes the use of at least three separate parties, a First Party, a Second Party, and a Third Party, with the First Party holding First Party Information, and the Third Party having an interest in Third Party Information held by the Second Party. The First Party requests to access Third Party Information held by the Second Party. The First Party's request is forwarded from the Second Party to the Third Party and is accompanied by some form of authorization information. Authorization is provided to the First Party by the Third Party by the transfer of the authorization information from the Third Party to said First Party, which authorizes the First Party to obtain the Third Party Information from the Second Party. Although at least three parties can be involved, two of these parties could be the same.

Abstract: A computer aided method for establishing secondary market-relevant price for a bond issued by a corporate entity involves accessing data relating to executed secondary market trades for a bonds issued by the entity, analyzing the data using the computer to select a subset of the information based upon application of at least one specified criterion, and using the subset, establishing an entity specific yield curve for the entity so that, using a bond pricing model, an anticipated price for the bond can be calculated using a point on the established entity specific yield curve that corresponds to the bond.

Abstract: The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and modulating serotonin levels.

Abstract: Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Abstract: A device for applying a coating medium onto a substrate, includes at least one spray valve that has a nozzle opening that can be adjusted with regard to its effective outlet area using a closing mechanism, whereby the substrate can be moved past the spray valve, which can be supplied with the coating medium under pressure via a supply line, whereby the positioning device is assigned a regulator that has at least one target value input for the instantaneously required outflow rate of the coating medium from the spray valve and at least one actual value input for the mass flow rate through a supply section arranged in front of the nozzle opening, and from the deviation between these values, the regulator forms an adjustment signal that moves the positioning device in the direction to offset the deviation.

Abstract: This invention provides compounds of the formula: wherein R1 and R2 are each, independently, H, alkyl, cycloalkyl, —CH2-cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, or phenoyl or thiophenoyl; R3 and R4 are each, independently, H, alkyl or cycloalkyl; R5 is H or alkyl; R6 is H or; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions and methods utilizing these compounds for the treatment or prevention of disorders including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.