Patents by Inventor Robert W. Doms

Robert W. Doms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins
    Patent number: 8158130
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: April 17, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Robert W Doms, Joseph Rucker, Trevor L Hoffman, Paul Bates, James A Hoxie, Michael J Endres, John Balliet, Dennis L Kolson
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Patent number: 7371846
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: May 13, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Patent number: 6849261
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: February 1, 2005
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Publication number: 20030091594
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Application
    Filed: July 16, 2002
    Publication date: May 15, 2003
    Applicant: University of Pennsylvania
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030008376
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 9, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030008391
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 9, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030008279
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 9, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030003447
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 2, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Lipoparticle comprising a protein and methods of making and using the same
    Publication number: 20020183247
    Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Application
    Filed: December 21, 2001
    Publication date: December 5, 2002
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Joseph Rucker, Trevor L. Hoffman, Paul Bates, James A. Hoxie
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Patent number: 6475718
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: November 5, 2002
    Assignees: Schering Aktiengesellschaft, The Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • CD4-independent HIV envelope proteins as vaccines and therapeutics
    Patent number: 6420545
    Abstract: The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: July 16, 2002
    Assignees: The Trustees of the University of Pennsylvania, Duke University
    Inventors: James A. Hoxie, Celia C. LaBranche, Robert W. Doms, Trevor L. Hoffman
  • Oligomeric HIV-1 envelope glycoproteins
    Patent number: 6171596
    Abstract: Immunogenic compositions and methods of stimulating an immune response against the envelope protein of HIV-1. Immunogenic compositions include a purified oligomeric structure that comprises a C-terminally truncated form of HIV-1 gp160 protein that is missing the gp41 transmembrane domain. The gp120-gp41 proteolytic processing site is retained in one form of the composition and is deleted in a different form of the composition. In one embodiment, the engineered env protein is proteolytically cleaved, but the gp120 and gp41 components of the complex remain noncovalently associated. Immunization with these compositions advantageously stimulates the production of conformation-dependent antibodies.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: January 9, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Patricia L. Earl, Christopher C. Broder, Robert W. Doms, Bernard Moss
  • Oligomeric HIV-1 envelope glycoproteins
    Patent number: 6039957
    Abstract: The present invention relates to methods for producing recombinant HIV-1 envelope (env) oligomers for use as immunogens. When gp140 oligomeric glycoproteins were purified by sucrose velocity gradient sedimentation, and then used to immunize mice, the resulting humoral immune response was skewed toward the production of antibodies that recognize conformation-dependent epitopes on the HIV-1 env protein. Assays for HIV-1 infections are described, as well as immonogens for vaccinating against HIV-1 infection.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: March 21, 2000
    Assignee: United States of America, as represented by the Department of Health and Human Services
    Inventors: Patricia L. Earl, Christopher C. Broder, Robert W. Doms, Bernard Moss