Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes S-Adenosylmethionine (SAM), and a component selected from an aminosugar or salts thereof (e.g., glucosamine) or glycosaminoglycans (e.g., chondroitin salts) or mixtures or fragments thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine.

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes S-Adenosylmethionine (SAM), and a component selected from an aminosugar or salts thereof (e.g., glucosamine) or glycosaminoglycans (e.g., chondroitin salts) or mixtures or fragments thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine.

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes S-Adenosylmethionine (SAM), and a component selected from an aminosugar or salts thereof (e.g., glucosamine) or glycosaminoglycans (e.g., chondroitin salts) or mixtures or fragments thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine.

Abstract: The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes S-Adenosylmethionine (SAM), and a component selected from an aminosugar or salts thereof (e.g., glucosamine) or glycosaminoglycans (e.g., chondroitin salts) or mixtures or fragments thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine.

Abstract: A water pump normally used in a water filtering system for a circulating water of a swimming pool water through a water filter cartridge is used to clean the filter by coupling a 3-way valve or an in line valve and a tee in the piping between the pump and the water filter. In the a first position of the valve, the filter housing receives the entire water output from the pump and a second position the entire water output of the pump is diverted to a flexible hose secured to first water discharge wand. A circular ring-shaped manifold with an array of water discharged apertures direct streams of water radially outward into the filter cartridge in a direction opposite to the flow of water through the filter cartridge when located in a filter housing for hydraulically flush debris from a filter cartridge. A second wand with a C-shaped manifold is then connected to the hose and used direct water streams onto the outer periphery of the filter.

Abstract: A therapeutic composition for the protection, treatment and repair of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes glucosamine and preferably chondroitin sulfate or fragments thereof. The composition optionally includes manganese ascorbate which catalyzes the production of collagen and proteoglycans from the glucosamine and chondroitin sulfate.

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes S-Adenosylmethionine (SAM), and a component selected from an aminosugar or salts thereof (e.g., glucosamine) or glycosaminoglycans (e.g., chondroitin salts) or mixtures or fragments thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine.

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes S-Adenosylmethionine (SAM), and a component selected from an aminosugar or salts thereof (e.g., glucosamine) or glycosaminoglycans (e.g., chondroitin salts) or mixtures or fragments thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine.

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the protection, treatment of connective tissue in mammals by the administration of the composition. The composition includes at least two compounds selected from S-Adenosylmethionine (SAM), an aminosugar selected from the group consisting of glucosamine, glucosamine salts, glucosamine hydrochloride, galactosamine, N-acetylglucosamine, and fragments, mixtures or salts thereof, and a glycosaminoglycan or glycosaminoglycan-like compound selected from the group consisting of chondroitin, chondroitin salts, hyaluronic acid, glucuronic acid, iduronic acid, keratan sulfate, keratin sulfate, heparan sulfate, dermatin sulfate, PPS, sodium PPS, calcium PPS, oversulfated GAGs, and fragments, salts, and mixtures thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix.

Abstract: A therapeutic composition for the protection, treatment and repair of connective tissue in humans and animals and a method for the treatment of connective tissue in humans and animals by the administration of the composition. The composition includes aminosugars and glycosaminoglycans.

Abstract: A trash collection and compacting apparatus primarily intended for use onboard an aircraft comprising a stationary compactor unit and interrelated movable trolley unit, the trolley unit having a plurality of separate trash collection chambers into which trash is deposited and compacted. The trolley unit includes wheels for moving the trolley through an aircraft for the collection of trash, and support rails for supporting the trolley unit on the compactor unit for the direct compaction of trash in the trolley. The compactor unit includes a compaction ram mounted on a carriage assembly for movement into discrete positions overlying each collection chamber of the trolley unit, and supports the trolley so that compaction forces are not transmitted to the aircraft.

Abstract: A trash collection and compacting apparatus primarily intended for use onboard an aircraft comprising a stationary compactor unit and interrelated movable wheeled trolley unit, the trolley unit having a plurality of separate trash collection chambers into which trash is deposited and compacted and support rails for supporting the trolley unit on the compactor unit for the direct compaction of trash in the trolley. The trolley unit also has separable sides to facilitate removal of compacted trash, and multiple fail safe locks and latches to ensure that the sides are not inadvertently separated during trash collection and compaction. Fire doors are provided to close the chambers, and removable trash bins are disposed in each trash chamber to facilitate handling of compacted trash, the bins having separable sides for emptying the compacted trash therefrom.

Abstract: A therapeutic composition for the protection, treatment and repair of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes glucosamine and preferably chondroitin sulfate. The composition further includes manganese ascorbate which catalyzes the production of collagen and proteoglycans from the glucosamine and the chondroitin sulfate.

Abstract: A motor vehicle is disclosed including an apparatus for preventing theft of a spare tire, including a tire rim forming an aperture, a spare tire mounted on the rim, a bracket, sling or cable lift for securing the spare tire and rim, a metal shaft securely affixed to the motor vehicle, a metal strap looping metal shaft, a shackle engaging the rim and both ends of the strap by passing through an aperture formed near each end of the strap and the aperture formed by the rim, and a locking device for locking onto both ends of the shackle.

Abstract: A slide gate has a frame made up of parallel channel guides extending vertically from and cooperating with a horizontal bottom to define a gate opening. The channel guides each have mutually spaced first and second guide flanges protruding laterally into the gate opening. A gate disc is supported by the frame for vertical movement between a lowered position resting on the frame bottom and closing off the gate opening, and an open position spaced thereabove. The gate disc has side portions received between the first and second guide flanges of the channel guides, and these side portions carry seal assemblies. A plurality of vertically spaced pivotal pressure pads are mounted on each of the channel guides between their respective first and second guide flanges.