Patents by Inventor Robert W. Klipper

Robert W. Klipper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .sup.99m TC labeled liposomes
    Patent number: 5158760
    Abstract: The invention relates to a .sup.99m Tc-labeled liposome encapsulated protein and to a highly efficient method of radiolabeling liposome encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposome-encapsulated hemoglobin. The liposome-encapsulated .sup.99m Tc labeled hemoglobin is highly stable in vitro and in vivo and is suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of using technetium-.sup.99m labeled liposome encapsulated hemoglobin to label neutrophils. A kit method which could be used for the convenient preparation of .sup.99m Tc-labeled liposome encapsulated hemoglobin for clinical use is also disclosed.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: October 27, 1992
    Assignees: Board of Regents, The University of Texas System, The United States of America as represented by the Secretary of the Navy
    Inventors: William T. Phillips, Robert W. Klipper, James H. Timmons, Alan S. Rudolph
  • .sup.99m Tc labeled liposomes
    Patent number: 5143713
    Abstract: The invention relates to the efficient preparation of radionuclide labeled liposomes and radionuclide-labeled liposome-encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposomes or liposome-encapsulated hemoglobin. .sup.99m Tc-labeled liposomes and liposome-encapsulated .sup.99m Tc labeled hemoglobin are highly stable in vitro and in vivo and are suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of labeling neutrophils using .sup.99m technetium-labeled liposomes or liposome-encapsulated hemoglobin. A kit method useful for the convenient preparation of .sup.99m Tc-labeled liposomes or liposome-encapsulated hemoglobin for clinical use is also disclosed.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: September 1, 1992
    Assignees: Board of Regents, The University of Texas System, The United States of America as represented by the Secretary of the Navy
    Inventors: William T. Phillips, Robert W. Klipper, James H. Timmons, Alan S. Rudolph