Patents by Inventor Robert W. Marquis

Robert W. Marquis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CALCILYTIC COMPOUNDS
    Publication number: 20140057980
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: November 1, 2013
    Publication date: February 27, 2014
    Applicant: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20130345258
    Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 26, 2013
    Applicant: Glaxosmithline LLC
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam Kenneth Charnley, Pamela A. Haile, Robert W. Marquis, JR., John F. Mehlmann, Joseph J. Romano, Robert R. Singhaus, JR., Gren Z. Wang
  • Calcilytic compounds
    Patent number: 8586631
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: November 19, 2013
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Calcilytic compounds
    Patent number: 8399517
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: March 19, 2013
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • AMINO-QUINOLINES AS KINASE INHIBITORS
    Publication number: 20130053375
    Abstract: Disclosed are quinoline compounds having the formula: wherein R1, R2 and A are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: May 6, 2011
    Publication date: February 28, 2013
    Inventors: Michael Jonathan Bury, Linda N. Casillas, Adam Kenneth Charnley, Michael P. DeMartino, Xiaoyang Dong, Patrick Eidam, Pamela A. Haile, Philip Anthony Harris, Ami Lakdawala Shah, Bryan W. King, Robert W. Marquis, JR., John F. Mehlmann, Joseph J. Romano, Clark A. Sehon
  • INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20130023532
    Abstract: Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: March 26, 2011
    Publication date: January 24, 2013
    Inventors: Linda N. Casillas, Subhas J. Chakravorty, Adam Kenneth Charnley, Pamela A. Haile, Terry Vincent Hughes, Jae U. Jeong, Jianxing Kang, Ami Lakdawala Shah, Lara Kathryn Leister, Robert W. Marquis, JR., Nathan Andrew Miller, Daniel J. Price, Clark A. Sehon, Gren Z. Wang, Daohua Zhang, Patrick Eidam
  • Calcilytic compounds
    Patent number: 7902394
    Abstract: Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: March 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Robert W. Marquis, Jr., Joshi M. Ramanjulu, Robert Trout
  • Calcilytic Compounds
    Publication number: 20110054021
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: September 30, 2010
    Publication date: March 3, 2011
    Inventors: ROBERT W. MARQUIS, LINDA N. CASILLAS, JOSHI M. RAMANJULU, JAMES FRANCIS CALLAHAN
  • Calcilytic compounds
    Patent number: 7829594
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: November 9, 2010
    Assignee: GlaxoSmithKline, LLC
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • NOVEL COMPOUNDS
    Publication number: 20100227856
    Abstract: This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted piperidines, according to Formula I Specifically, the invention is directed to compounds according to Formula I wherein R1 is optionally substituted aryl; X is CH2, S, or SO2; and n=1 or 2.
    Type: Application
    Filed: February 16, 2007
    Publication date: September 9, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventor: Robert W. Marquis, JR.
  • Calcilytic Compounds
    Publication number: 20100029782
    Abstract: Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided.
    Type: Application
    Filed: December 18, 2007
    Publication date: February 4, 2010
    Applicant: Smithkline Beecham Corporation
    Inventors: Robert W. Marquis, JR., Joshi M. Ramanjulu, Robert Trout
  • Protease inhibitors
    Patent number: 7563784
    Abstract: The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: July 21, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Maxwell D. Cummings, Robert W. Marquis, Jr., Yu Ru, Scott K. Thompson, Daniel F. Veber, Dennis S. Yamashita
  • Calcilytic Compounds
    Publication number: 20090163589
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: February 26, 2009
    Publication date: June 25, 2009
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Calcilytic Compounds
    Publication number: 20090137557
    Abstract: Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
    Type: Application
    Filed: November 21, 2006
    Publication date: May 28, 2009
    Inventors: Thomas Wen Fu Ku, Hong Lin, Juan I. Luengo, Robert W. Marquis Jr., Joshi M. Ramanjulu, Robert Trout, Dennis S. Yamashita
  • Acyclic 1,4-Diamines and Uses Thereof
    Publication number: 20090105259
    Abstract: This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain acyclic diamines, which are agonists of TRPV4 channel receptors.
    Type: Application
    Filed: September 8, 2006
    Publication date: April 23, 2009
    Inventors: Jae U. Jeong, Robert W. Marquis
  • Calcilytic compounds
    Patent number: 7514473
    Abstract: Novel Calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: April 7, 2009
    Assignee: SmithKline Beecham, Corp.
    Inventors: Robert W. Marquis, Linda N. Casillas, Joshi M. Ramanjulu, James Francis Callahan
  • Novel Compounds
    Publication number: 20090012011
    Abstract: This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted pyrrolidines, according to Formula I Specifically, the invention is directed to compounds according to Formula I wherein R1 is H or C1-C6 alkyl; R2 is H or OH; and R3 is an optionally substituted aryl.
    Type: Application
    Filed: January 11, 2007
    Publication date: January 8, 2009
    Applicant: SmithKline Beecham Corporation
    Inventors: Linda N. Casillas, Robert W. Marquis, JR.
  • Novel Compounds
    Publication number: 20080318945
    Abstract: This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted piperazines, according to Formula I A compound of formula I wherein Z is bond or NH; R1 is aryl or optionally substituted heteroaryl; R2 is H, optionally substituted C1-6alkyl, or optionally substituted C2-6alkenyl; R3 and R7 are independently H, optionally substituted C1-6alkyl, or aryl; R4 is H or optionally substituted C1-6alkyl; R5 is H or C1-6alkyl; R6 is H or C1-6alkyl; and X and X? are independently O or H2; or wherein R3 and R4 together form a part of morpholinyl, piperadinyl, or aziridinyl ring; and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: December 15, 2006
    Publication date: December 25, 2008
    Inventors: Linda N. Casillas, Robert W. Marquis, JR.
  • Calcilytic Compounds
    Publication number: 20080234370
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: February 4, 2005
    Publication date: September 25, 2008
    Inventors: Robert W. Marquis, Joshi M. Ramanjulu
  • Protease inhibitors
    Patent number: 7071184
    Abstract: The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: July 4, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Maxwell D. Cummings, Robert W. Marquis, Jr., Daniel F. Veber, Dennis S. Yamashita