Abstract: Computer method and apparatus manage requests to make changes to a given software system (e.g., application program or program portion). The invention method and apparatus form a change request object representing a user's request to make a change to the given software system. The invention method and apparatus form one or more hierarchies of objects and sub-objects to represent work to be performed and work performed in making the requested change. One embodiment creates a root issue object for each change request object and allows a user to partition an issue object into issue sub-objects. The embodiment (a) allows a user to create a task object to define the work needed to address an issue and allows a user to partition a task object into task sub-objects, and (b) allows a user to create an activity object to track work performed and allows a user to partition an activity object into activity sub-objects. Issue objects and issue sub-objects are relatable to task objects and task sub-objects.

Abstract: Computer method and apparatus manage requests to make changes to a given software system (e.g., application program or program portion). The invention method and apparatus form a change request object representing a user's request to make a change to the given software system. The invention method and apparatus form one or more hierarchies of objects and sub-objects to represent work to be performed and work performed in making the requested change. One embodiment creates a root issue object for each change request object and allows a user to partition an issue object into issue sub-objects. The embodiment (a) allows a user to create a task object to define the work needed to address an issue and allows a user to partition a task object into task sub-objects, and (b) allows a user to create an activity object to track work performed and allows a user to partition an activity object into activity sub-objects. Issue objects and issue sub-objects are relatable to task objects and task sub-objects.

Abstract: Cyclic tetrapeptide compounds derived from apicidin therapeutically inhibit histone deacetylase activity, are represented by Formula I: 1

Abstract: Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.

Abstract: Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.

Abstract: Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.

Abstract: The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-oxa and 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.

Abstract: The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-oxa end 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.

Abstract: A clock circuit for a microcomputer having a clock input, a halt mode state output and an interrupt input, comprises: a clock pulse generator having an output, a switch for applying a pulsed output to the interrupt input of the microcomputer to indicate a start of operation; a latch receptive of the output of the switch to change from a first state to a second state, gates receptive of the output of the clock pulse generator and the latch for applying clock pulses to the microcomputer when the logic is in the second state and preventing the application of clock pulses to the microcomputer when the logic is in the first state and circuitry for applying the halt mode state output to the logic circuit to disable same from the second state to the first state.

Abstract: A sensor-integrator circuit having a sensor for producing a current varying in accordance with the sensed parameter or a reference current source, a comparator having inverting and noninverting inputs and an output and charge storage device coupled to the inverting input. The circuit is energized to obtain a given positive steady state reset voltage, a reference voltage is applied to the noninverting input of a comparator which is less positive than the steady state voltage and integration is initiated solely by alternately applying the current from the sensor and the reference current to the inverting input of the comparator.

Abstract: A combination cable crimper and cutter. A frame mounts a piston for reciprocating axial movement. A reciprocating drive is connected to the piston. A pair of cable-crimping jaws is pivotally mounted on the frame and connected by links to the piston. A cutter anvil is mounted on the frame adjacent one of the jaws. A cutter is mounted on the jaw in cable-cutting relation to the cutter anvil.

Abstract: A method of and apparatus for detecting a ground on an electric furnace comprising connecting an electrode, which is located in the furnace, to ground potential and sensing the current flowing from the electrode to ground. The method and apparatus may also include comparing the sensed current with a first and second reference signal and actuating an appropriate alarm when the sensed current is greater than the first reference signal or less than the second reference signal and interrupting the electrical power to the furnace when the sensed current is greater than the first reference signal.