Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A novel dye system and improvement to the conventional method of preparing highly colored soap and synthetic detergent bars is disclosed. In the making of soap bars, for example, a solution of water, glycerine and dye is added to soap pellets in the amalgamator along with a slurry of uncolored soap additives to produce a highly colored soap product, thus solving the problem of introducing high concentrations of dyes to soap pellets at the amalgamator, particularly in the presence of a slurry heavy with additives. This makes it feasible for one slurry tank to serve multiple amalgamators producing different highly colored bar products.