Abstract: A topical nerve stimulator patch and system are provided including a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

Abstract: One example provides a nerve stimulation treatment using electrodes coupled to a user. Examples determine a target charge level and output a series of pulses from the electrodes. For each pulse outputted, examples measure a charge value of the pulse and compare the charge value to the target charge level. If the charge value is greater than the target charge level, examples reduce a strength level of a subsequent outputted pulse. If the charge value is less than the target charge level, examples increase the strength level of a subsequent outputted pulse.

Abstract: A topical nerve activation patch includes a flexible substrate, a dermis conforming bottom surface of the substrate comprising adhesive and adapted to contact a dermis of a user, a flexible top outer surface of the substrate approximately parallel to the bottom surface, a plurality of electrodes positioned on the patch proximal to the bottom surface and located beneath the top outer surface and coupled to the flexible substrate, a power source, and electronic circuitry that generates an output voltage applied to the electrodes. The electronic circuitry includes a controller, a voltage monitoring circuit coupled to the controller, a current monitoring circuit coupled to the controller, a switch coupled to the controller and a boosted voltage circuit coupled to the switch and the power source.

Abstract: A topical nerve activation patch includes a flexible substrate, a dermis conforming bottom surface of the substrate comprising adhesive and adapted to contact a dermis of a user, a flexible top outer surface of the substrate approximately parallel to the bottom surface, a plurality of electrodes positioned on the patch proximal to the bottom surface and located beneath the top outer surface and coupled to the flexible substrate, a power source, and electronic circuitry that generates an output voltage applied to the electrodes. The electronic circuitry includes a controller, a voltage monitoring circuit coupled to the controller, a current monitoring circuit coupled to the controller, a switch coupled to the controller and a boosted voltage circuit coupled to the switch and the power source.

Abstract: One example provides a nerve stimulation treatment using electrodes coupled to a user. Examples determine a target charge level and output a series of pulses from the electrodes. For each pulse outputted, examples measure a charge value of the pulse and compare the charge value to the target charge level. If the charge value is greater than the target charge level, examples reduce a strength level of a subsequent outputted pulse. If the charge value is less than the target charge level, examples increase the strength level of a subsequent outputted pulse.

Abstract: A topical nerve stimulator patch and system are provided including a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

Abstract: A topical nerve activation patch includes a flexible substrate, a dermis conforming bottom surface of the substrate comprising adhesive and adapted to contact a dermis of a user, a flexible top outer surface of the substrate approximately parallel to the bottom surface, a plurality of electrodes positioned on the patch proximal to the bottom surface and located beneath the top outer surface and coupled to the flexible substrate, a power source, and electronic circuitry that generates an output voltage applied to the electrodes. The electronic circuitry includes a controller, a voltage monitoring circuit coupled to the controller, a current monitoring circuit coupled to the controller, a switch coupled to the controller and a boosted voltage circuit coupled to the switch and the power source.

Abstract: A topical nerve stimulator patch and system are provided including a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

Abstract: One example provides a nerve stimulation treatment using electrodes coupled to a user. Examples determine a target charge level and output a series of pulses from the electrodes. For each pulse outputted, examples measure a charge value of the pulse and compare the charge value to the target charge level. If the charge value is greater than the target charge level, examples reduce a strength level of a subsequent outputted pulse. If the charge value is less than the target charge level, examples increase the strength level of a subsequent outputted pulse.

Abstract: A drill template includes a vacuum housing with a skirt having a CAD-formed contact surface formed to an exact fit with a mold line surface of a structure. The drill template includes at least one drill guide bushing extending through the vacuum housing from a top surface to an interior surface of the vacuum housing; a vacuum port integral to the vacuum housing; and at least one index hole for positioning and aligning the vacuum housing on the structure. Index holes extend from the top surface through to the CAD-formed contact surface of the vacuum housing. A CAD-formed edge of part locator is formed according to a CAD solid model of the aircraft fuselage and fits to a precise location of the structure for precisely positioning the template on the structure. A vacuum port provides vacuum to the interior of the vacuum housing for removing drilling debris and dust.

Abstract: An apparatus for achieving weight loss in a patient is disclosed. The apparatus has a barrier material and an applicator for dispensing the barrier material about the intestine. An injector is used to place the barrier material to block nutrient transfer from the intestine into the blood stream. The barrier material is a polymerizable adhesive that can be injected interstitially between layers of the intestine, or injected into vascular structures to partially block the flow of blood to the nutrient absorbing layers.

Abstract: The present invention provides a catheter for detecting and treating diseased tissue in a blood vessel or other hollow body organ. The catheter comprises an elongated tubular catheter shaft having a distal end comprising a light transmission zone. A first fiber lumen in the catheter shaft contains a diagnostic optical fiber having a distal end terminating within the light transmission zone for emitting and receiving light through the light transmission zone. A diagnostic subassembly at the proximal end and in communication with the diagnostic optical fiber processes diagnostic light for use in connection with a diagnostic method for detecting diseased tissue. A second fiber lumen can be provided in the catheter shaft for containing a treatment optical fiber for delivering treatment light from a light source at the proximal end of the catheter shaft to the light transmission zone.

Abstract: A method and apparatus for making a part. A digital model of the part is formed. A digital design of a tool usable to create the part is formed. The tool is created using an additive manufacturing process and the digital design of the tool. The tool is usable in a press machine to manufacture the part.

Abstract: An adjustable drill template has a base plate and a plurality of drill blocks. The drill blocks are movably coupled to the base plate. The drill blocks can move along the length of the base plate so that the drill blocks can be configured to conform to a desired hole pattern. A locking device coupled to each drill block will hold each drill block in a desired position.

Abstract: A drill template includes a vacuum housing with a skirt having a CAD-formed contact surface formed to an exact fit with a mold line surface of a structure. The drill template includes at least one drill guide bushing extending through the vacuum housing from a top surface to an interior surface of the vacuum housing; a vacuum port integral to the vacuum housing; and at least one index hole for positioning and aligning the vacuum housing on the structure. Index holes extend from the top surface through to the CAD-formed contact surface of the vacuum housing. A CAD-formed edge of part locator is formed according to a CAD solid model of the aircraft fuselage and fits to a precise location of the structure for precisely positioning the template on the structure. A vacuum port provides vacuum to the interior of the vacuum housing for removing drilling debris and dust.

Abstract: A3 agonists, methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia.

Abstract: A3 agonists, methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia.

Abstract: The present invention provides a catheter for detecting and treating diseased tissue in a blood vessel or other hollow body organ. The catheter comprises an elongated tubular catheter shaft having a distal end comprising a light transmission zone. A first fiber lumen in the catheter shaft contains a diagnostic optical fiber having a distal end terminating within the light transmission zone for emitting and receiving light through the light transmission zone. A diagnostic subassembly at the proximal end and in communication with the diagnostic optical fiber processes diagnostic light for use in connection with a diagnostic method for detecting diseased tissue. A second fiber lumen can be provided in the catheter shaft for containing a treatment optical fiber for delivering treatment light from a light source at the proximal end of the catheter shaft to the light transmission zone.

Abstract: This invention relates to methods for preparing certain cholesteryl ester transfer protein (CETP) inhibitors and intermediates useful in the preparation of said CETP inhibitors.

Abstract: This invention relates to intermediates useful in the preparation of CETP inhibitors and methods of preparation thereof.