Patents by Inventor Robert W. Siegel

Robert W. Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20190162726
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: December 31, 2018
    Publication date: May 30, 2019
    Inventors: David J. Hawksworth, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Susan E. Brophy, Dinesh O. Shah, Joan D. Tyner, Robert N. Ziemann
  • Anti-antibodies and methods of use
    Patent number: 10215754
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: February 26, 2019
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20170023568
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: October 6, 2016
    Publication date: January 26, 2017
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-antibodies and methods of use
    Patent number: 9482667
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 1, 2016
    Assignee: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-glucagon antibodies and uses thereof
    Patent number: 9453073
    Abstract: Provided are monoclonal antibodies, or antigen-binding fragments thereof, that bind to glucagon. These antibodies are useful in immunoassays of glucagon levels, and/or in vivo, ex vivo or in vitro immunochemical and other imaging methods for detecting glucagon levels, and for diagnostic, prognostic and predictive purposes, and for optimizing therapeutic regimens in patients in which glucagon signaling is implicated in pathogenesis.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: September 27, 2016
    Assignee: Eli Lilly and Company
    Inventors: David Edward Watson, Robert W. Siegel, Nan Jia, John Harrison Sloan
  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20150212083
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: April 14, 2015
    Publication date: July 30, 2015
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-antibodies and methods of use
    Patent number: 9073984
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: July 7, 2015
    Assignee: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • ANTI-GLUCAGON ANTIBODIES AND USES THEREOF
    Publication number: 20140335096
    Abstract: Provided are monoclonal antibodies, or antigen-binding fragments thereof, that bind to glucagon. These antibodies are useful in immunoassays of glucagon levels, and/or in vivo, ex vivo or in vitro immunochemical and other imaging methods for detecting glucagon levels, and for diagnostic, prognostic and predictive purposes, and for optimizing therapeutic regimens in patients in which glucagon signaling is implicated in pathogenesis.
    Type: Application
    Filed: November 27, 2012
    Publication date: November 13, 2014
    Inventors: David Edward Watson, Robert W. Siegel, Nan Jia, John Harrison Sloan
  • Antibodies that bind to mammalian NGAL and uses thereof
    Patent number: 8846036
    Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: September 30, 2014
    Assignee: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Robert N. Ziemann, Frank C. Grenier, Ryan F. Workman, Lowell Tyner
  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20120122125
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: January 19, 2012
    Publication date: May 17, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Immunosuppressant binding antibodies and methods of obtaining and using same
    Patent number: 8022188
    Abstract: The present invention relates among other things to antibodies that immunospecifically bind to at least one agent of interest (e.g., an immunosuppressive agent), methods for producing such antibodies, and immunoassays that employ said antibodies. Additionally, the present invention also relates to methods for selecting an antibody for use in a diagnostic immunoassay and methods for selecting an antigen for use in a diagnostic immunoassay. The present invention further relates to the improvement of antibody recognition of an active parent drug in the presence of one or more of its major metabolites.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: September 20, 2011
    Assignee: Abbott Laboratories
    Inventors: Robert W. Siegel, Joan D. Tyner, Terry Y. Nakagawa
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20100227775
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: May 21, 2010
    Publication date: September 9, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20090269777
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: April 16, 2008
    Publication date: October 29, 2009
    Applicant: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Ryan F. Workman, Robert N. Ziemann
  • ANTIBODIES THAT BIND TO MAMMALIAN NGAL AND USES THEREOF
    Publication number: 20090263894
    Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
    Type: Application
    Filed: December 5, 2008
    Publication date: October 22, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-T. Cruzi Antibodies and Methods of Use
    Publication number: 20090203037
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: December 23, 2008
    Publication date: August 13, 2009
    Applicant: Abbott Laboratories
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Robert N. Ziemann
  • ANTIBODIES THAT BIND TO MAMMALIAN NGAL AND USES THEREOF
    Publication number: 20090124022
    Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
    Type: Application
    Filed: April 16, 2008
    Publication date: May 14, 2009
    Applicant: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann, Lowell J. Tyner
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20090123946
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: December 5, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann, Lowell J. Tyner
  • Immunosuppressant binding antibodies and methods of obtaining and using same
    Publication number: 20080176756
    Abstract: The present invention relates among other things to antibodies that immunospecifically bind to at least one agent of interest (e.g., an immunosuppressive agent), methods for producing such antibodies, and immunoassays that employ said antibodies. Additionally, the present invention also relates to methods for selecting an antibody for use in a diagnostic immunoassay and methods for selecting an antigen for use in a diagnostic immunoassay. The present invention further relates to the improvement of antibody recognition of an active parent drug in the presence of one or more of its major metabolites.
    Type: Application
    Filed: April 23, 2007
    Publication date: July 24, 2008
    Inventors: Robert W. Siegel, Joan D. Tyner, Terry Y. Nakagawa
  • Use of nucleic acid molecules as antiviral agents
    Patent number: 6500652
    Abstract: The invention provides antiviral compounds and compositions comprising a viral specific oligonucleotide. Also provided are methods to inhibit or treat viral infections with the compounds or compositions of the invention.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: December 31, 2002
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: C. Cheng Kao, Robert W. Siegel
  • USE OF NUCLEIC ACID MOLECULES AS ANTIVIRAL AGENTS
    Publication number: 20020103143
    Abstract: The invention provides antiviral compounds and compositions comprising a viral specific oligonucleotide. Also provided are methods to inhibit or treat viral infections with the compounds or compositions of the invention.
    Type: Application
    Filed: March 25, 1999
    Publication date: August 1, 2002
    Inventors: C. CHENG KAO, ROBERT W. SIEGEL