Abstract: This invention relates to certain 3-aryl or 3-heteroaryl pyrazoles with 4,5(3,4)-bicyclic ring fusion which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.

Abstract: The invention provides compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; wherein R.sub.50 is hydrogen or C.sub.1-4 alkyl, A.sub.51 is oxygen, sulphur or a group of the formula --NR.sub.52 -- wherein R.sub.52 is hydrogen or C.sub.1-4 alkyl; A.sub.50 comprises i) a mono or bicyclic aromatic ring optionally containing one or more nitrogen, oxygen or sulphur atoms, ii) a cycloalkendiyl group, or iii) an acyclic bridging group having a chain of one, two or three atoms between the cyclobutenedione group and X.sub.50, said chain being a chain of one or two carbon atoms or a chain of one carbon atom and one or more nitrogen, oxygen or sulphur atoms or iv) a bond; X.sub.50 is either a bond or a spacer group providing a chain between A.sub.50 and B.sub.50 of one or two atoms length; B.sub.

Abstract: An elongated rigid bar is arranged to be secured at one of its ends to a power unit and is enclosed through most of its length in a rigid housing. Longitudinal passageways are provided interiorly of the housing for receiving a cross link drive chain trained over a sprocket on the power unit and on a cross shaft supported at a free end of the housing. The cross shaft supports digging units. A ground engaging support wheel is attached to the housing adjacent its free end. The housing has a semi-flexible guard mounted on it adjacent the digging units.

Abstract: A spacecraft or transfer vehicle for transportation of a payload from a space shuttle parking orbit to a higher operation orbit, wherein the transfer vehicle utilizes housekeeping subsystems integrated into the payload, to avoid unnecessary duplication of these subsystems, for such functions as power supply, guidance, control, and communications. The transfer vehicle disclosed includes a propulsion system with at least one low-thrust bipropellant liquid rocket engine, to provide a "soft" or low-acceleration ascent, and employs two tanking stages, each having four propellant tanks, arranged symmetrically in a circular configuration. The first stage of four tanks is jettisoned during ascent, and the second stage, including the remaining four tanks, the rocket engine, and related supporting structure, is separated from the payload when the operational orbit is reached.