Patents by Inventor Robert W. Ward

Robert W. Ward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4961016
    Abstract: A dual-face, internally-mounted cooling fan is provided in a dynamoelectric machine, e.g. an alternating current generator. The generator includes a ventilated housing supporting a stator assembly and a rotor assembly. The fan includes a divider disk having a plurality of blades provided on each surface and is mounted to rotate with the rotor assembly. As the fan is rotated, a plurality of separate air currents are drawn axially into the housing for cooling. The divider disk prohibits substantial mixing of currents drawn from opposite ends before they are radially expelled from the housing.
    Type: Grant
    Filed: August 9, 1989
    Date of Patent: October 2, 1990
    Assignee: General Motors Corporation
    Inventors: Yuchi P. Peng, Melvin H. Hallmann, Robert W. Ward
  • Patent number: 4947065
    Abstract: A stator assembly for an alternating current generator. The stator core is a one-piece molded part that is formed of iron powder having a particle size in a range of about 10 to 250 microns. The powder is bound together by a thermoplastic material which covers the particles and which serves to insulate the particles from each other. The particles may be coated with phosphorus and the phosphorus layer overcoated with the thermoplastic material. A three-phase output stator winding is carried by the core and has conductor portions located in core slots.
    Type: Grant
    Filed: September 22, 1989
    Date of Patent: August 7, 1990
    Assignee: General Motors Corporation
    Inventors: Robert W. Ward, Robert E. Campbell, William E. Boys
  • Patent number: 4935404
    Abstract: Novel compounds of the formula (I), a process for their preparation and their use as collagenase inhibitors are described: ##STR1## in which R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen or alkyl; R.sub.3 is C.sub.3-6 alkyl; R.sub.4 is hydrogen, alkyl, --CH.sub.2 --Z where Z is optionally substituted phenyl or heteroaryl, or R.sub.4 is a group ##STR2## where R.sub.8 is hydrogen, alkyl or --CH.sub.2 --Ph where Ph is optionally substituted phenyl, and R.sub.9 is hydrogen or alkyl; and R.sub.5 is hydrogen or alkyl.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: June 19, 1990
    Assignee: Beecham Group p.l.c. of Beecham House
    Inventors: David J. Hunter, Roger E. Markwell, Robert W. Ward
  • Patent number: 4837238
    Abstract: Compounds of the formula (I): ##STR1## wherein: X is NR wherein R is hydrogen, C.sub.1-6 alkyl; oxygen; sulphur; SO; or SO.sub.2 ; or R and R.sub.3 taken together are C.sub.4-6 polymethylene;R.sub.1 is hydrogen or C.sub.1-6 alkyl; and R.sub.2 is CN, CR.sub.5 R.sub.6 Y where R.sub.5 and R.sub.6 are independently selected from hydrogen and C.sub.1-4 alkyl and Y is selected from hydrogen, OR.sub.7 or SR.sub.7 where R.sub.7 is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkanoyl, and NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkanoyl or R.sub.8 and R.sub.9 together are C.sub.4-6 polymethylene, or COR.sub.10 where R.sub.10 is C.sub.1-4 alkyl, provided that Y is other than hydrogen when R.sub.1 is hydrogen;orR.sub.2 is hydrogen C.sub.1-6 alkyl or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; and R.sub.1 is CN, CR.sub.5 R.sub.6 Y or COR.sub.10 as defined for R.sub.2 above;orR.sub.1 and R.sub.
    Type: Grant
    Filed: October 21, 1987
    Date of Patent: June 6, 1989
    Assignee: Beecham Group p.l.c.
    Inventors: Roger E. Markwell, Ian Hughes, Robert W. Ward
  • Patent number: 4833136
    Abstract: A compound of the formula (I) or a salt or solvate thereof: ##STR1## in which: R.sub.0 is hydrogen or C.sub.1-6 alkyl; or together with R.sub.3 is C.sub.4-6 polymethylene;R.sub.1 and R.sub.2 are both hydrogen; orR.sub.1 is hydrogen, C.sub.1-6 alkyl; and R.sub.2 is CN; CR.sub.5 R.sub.6 Y where R.sub.5 and R.sub.6 are independently selected from hydrogen and C.sub.1-4 alkyl and Y is selected from hydrogen, OR.sub.7 or SR.sub.7 where R.sub.7 is hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkanoyl, and NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkanoyl or together are C.sub.4-6 polymethylene; or COR.sub.10 where R.sub.10 is OH or C.sub.1-4 alkyl, or COR.sub.10 is a pharmaceutically acceptable ester or amide, orR.sub.2 is hydrogen, C.sub.1-6 alkyl, or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl, and R.sub.1 is CN, CR.sub.5 R.sub.6 Y or COR.sub.10 as defined for R.sub.2 above; orR.sub.1 and R.sub.
    Type: Grant
    Filed: January 29, 1987
    Date of Patent: May 23, 1989
    Assignee: Beecham Group p.l.c.
    Inventors: Roger E. Markwell, Robert W. Ward, Carol R. De Mello
  • Patent number: 4823032
    Abstract: An end frame and stator assembly for a dynamoelectric machine such as an alternating current generator. The assembly comprises a slotted stator core that supports a stator winding, a rotor bearing and a metallic heat dissipating insert that supports the bearing. The assembly has a plastic housing that is comprised of plastic material that is molded to the stator core and insert. The plastic housing does not encapsulate the stator winding. The metallic insert conducts heat away from the bearing and also adds stability to the plastic housing.
    Type: Grant
    Filed: August 1, 1988
    Date of Patent: April 18, 1989
    Assignee: General Motors Corporation
    Inventors: Robert W. Ward, Rodney G. Hunter, William E. Boys
  • Patent number: 4818754
    Abstract: A compound of the formula (1) or a salt or solvate thereof: ##STR1## in which: R.sub.0 is hydrogen or C.sub.1-6 alkyl;R.sub.1 and R.sub.2 are both hydrogen; orR.sub.1 is hydrogen, C.sub.1-6 alkyl; and R.sub.2 is CN; CR.sub.5 R.sub.6 Y where R.sub.5 and R.sub.6 are independently selected from hydrogen and C.sub.1-4 alkyl and Y is selected from hydrogen, OR.sub.7 or SR.sub.7 where R.sub.7 is hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkanoyl, and NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkanoyl or together are C.sub.4-6 polymethylene; or COR.sub.10 is OH or C.sub.1-4 alkyl, or COR.sub.10 is a pharmaceutically acceptable ester or amide; orR.sub.2 is hydrogen, C.sub.1-6 alkyl, or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; and R.sub.1 is CN, CR.sub.5 R.sub.6 Y or COR.sub.10 as defined for R.sub.2 above; orR.sub.1 and R.sub.2 together form C.sub.3 -C.sub.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: April 4, 1989
    Assignee: Beecham Group p.l.c. of Beecham House
    Inventors: Robert W. Ward, Roger E. Markwell, Ian Hughes
  • Patent number: 4716160
    Abstract: Compounds of formula (I) ##STR1## wherein: R is hydrogen or C.sub.1-6 alkyl;R.sub.1 and R.sub.2 are both hydrogen; orR.sub.1 is hydrogen, C.sub.1-6 alkyl; and R.sub.2 is CN; CR.sub.5 R.sub.6 Y where R.sub.5 and R.sub.6 are independently selected from hydrogen and C.sub.1-4 alkyl and Y is selected from hydrogen, OR.sub.7 or SR.sub.7 where R.sub.7 is hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkanoyl, and NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkanoyl or together are C.sub.4-6 polymethylene, or COR.sub.10 where R.sub.10 is OH or C.sub.1-4 alkyl, or COR.sub.10 is a pharmaceutically acceptable ester or amide; orR.sub.2 is hydrogen, C.sub.1-6 alkyl, or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; and R.sub.1 is CN, CR.sub.5 R.sub.6 Y or COR.sub.10 as defined for R.sub.2 above; orR.sub.1 and R.sub.2 together form C.sub.3 -C.sub.6 polymethylene optionally substituted by C.sub.1 -C.sub.4 alkyl;R.
    Type: Grant
    Filed: April 25, 1986
    Date of Patent: December 29, 1987
    Assignee: Beecham Group p.l.c.
    Inventors: Roger E. Markwell, Robert W. Ward, Carol R. de Mello
  • Patent number: 4670432
    Abstract: A compound of formula (I) or a salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl;R.sub.2 is hydrogen or C.sub.1-6 alkyl;R.sub.3 is C.sub.2-10 alkenyl or C.sub.1-10 alkyl substituted by hydroxy, C.sub.1-4 alkoxy, thiol, C.sub.1-4 alkylthio or NR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are independently hydrogen or C.sub.1-6 alkyl or together are C.sub.3-6 polymethylene;R.sub.4 and R.sub.5 are independently hydrogen or C.sub.1-4 alkyl; andR.sub.6 is hydrogen; or C.sub.1-4 alkyl or benzyl attached at nitrogen atom 1 or 2;having anti-inflammatory and/or anti-allergy activity.
    Type: Grant
    Filed: April 15, 1986
    Date of Patent: June 2, 1987
    Assignee: Beecham Group p.l.c.
    Inventors: Robert W. Ward, Roger E. Markwell
  • Patent number: 4621089
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: X is NR wherein R is hydrogen or C.sub.1-6 alkyl, oxygen, sulphur, SO or SO.sub.2 ;R.sub.1 is COR.sub.5 wherein R.sub.5 is hydroxy, or COR.sub.5 is a pharmaceutically acceptable ester or amide group; or CF.sub.3 ; and R.sub.2 is hydrogen, C.sub.1-6 alkyl or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; or R.sub.2 is COR.sub.5 as defined or CF.sub.3 and R.sub.1 is hydrogen;R.sub.3 is C.sub.1-10 alkyl, optionally substituted by hydroxy, C.sub.1-4 alkoxy, thiol, C.sub.1-4 alkylthio or NR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1-6 alkyl or together are C.sub.3-6 polymethylene; C.sub.2-10 alkenyl or phenyl optionally substituted by one or two of halogen, CF.sub.3, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, hydroxy, nitro, cyano, C.sub.2-10 acyloxy, NR.sub.8 R.sub.9 wherein R.sub.8 and R.sub.9 are independently selected from hydrogen, C.sub.1-6 alkyl, C.
    Type: Grant
    Filed: February 22, 1985
    Date of Patent: November 4, 1986
    Assignee: Beecham Group p.l.c.
    Inventors: Robert W. Ward, Ian Hughes
  • Patent number: 4548948
    Abstract: Compounds of formula (I): ##STR1## wherein: Ar is phenyl optionally substituted in the o-, m- or p-position by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, bromo, chloro or fluoro,pyrryl optionally N-substituted by C.sub.1-4 alkyl,2-furyl or 2-thienyl either optionally substituted in the 3-, 4- or 5-position by methyl, chloro or bromo, or3-furyl or 3-thienyl;X is oxygen, sulphur, sulphoxide or sulphone, Y is methylene, R.sub.1 and R.sub.3 are hydrogen or C.sub.1-4 alkyl, and R.sub.2 is hydrogen, C.sub.1-4 alkyl, fluoro, chloro or bromo, or X is methylene, Y is oxygen, R.sub.1 and R.sub.3 are both hydrogen, and R.sub.2 is hydrogen, fluoro, chloro or bromo; andR.sub.4 is hydrogen or C.sub.1-4 alkyl, or a salt thereof, have analgesic and/or anti-inflammatory activity.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: October 22, 1985
    Assignee: Beecham Group p.l.c.
    Inventors: Robert W. Ward, Stephen A. Smith, Roger E. Markwell
  • Patent number: 4396626
    Abstract: Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts and pro-drugs thereof, wherein: Ar is a phenyl group optionally substituted by one or two moieties selected from halogen, C.sub.1-4 alkyl, methoxy, methylthio or trifluoromethyl, or a 2-thienyl group or N-methyl-2-pyrryl group optionally substituted by one or two C.sub.1-4 alkyl groups;R is hydrogen or methyl; andn is 0 or 1having useful anti-inflammatory and/or analgesic activity, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: September 28, 1981
    Date of Patent: August 2, 1983
    Assignee: Beecham Group Limited
    Inventors: Robert W. Ward, Alexander C. Goudie
  • Patent number: 4385063
    Abstract: A compound of formula (I): ##STR1## wherein: R is C.sub.1-4 alkyl;R.sub.1 is hydrogen or C.sub.1-4 alkyl;one of A and B is sulphur, and the other of A and B is carbon doubly bound to the carbon spacing A and B; andthe dotted line represents an optionally present double bond;and pro-drugs thereof; and pharmaceutically acceptable salts thereof;have useful anti-inflammatory and analgesic activity.
    Type: Grant
    Filed: March 5, 1981
    Date of Patent: May 24, 1983
    Assignee: Beecham Group Limited
    Inventors: Alexander C. Goudie, Robert W. Ward, Howard E. Rosenberg
  • Patent number: 4359423
    Abstract: A compound of formula (II): ##STR1## wherein R is a C.sub.1-4 alkyl group;R.sub.1 is a hydrogen atom or a C.sub.1-4 alkyl group;R.sub.2 is a hydrogen or halogen atom, or a C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.1-4 alkylthio group;and pro-drugs thereof; and the pharmaceutically acceptable salts of the compounds of formula (II) and of their pro-drugs; has useful anti-inflammatory and analgesic activity.
    Type: Grant
    Filed: July 25, 1980
    Date of Patent: November 16, 1982
    Assignee: Beecham Group Limited
    Inventors: Alexander C. Goudie, Robert W. Ward