Patents by Inventor Robert W. WIETHE

Robert W. WIETHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaryl purine derivatives with improved bioavailability
    Patent number: 10696677
    Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 30, 2020
    Assignee: Research Triangle Institute
    Inventors: Rangan Maitra, Robert W. Wiethe, Yanan Zhang, George S. Amato
  • DIARYL PURINE DERIVATIVES WITH IMPROVED BIOAVAILABILITY
    Publication number: 20190352305
    Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).
    Type: Application
    Filed: December 20, 2017
    Publication date: November 21, 2019
    Inventors: Rangan Maitra, Robert W. Wiethe, Yanan Zhang, George S. Amato
  • PYRAZOLE COMPOUNDS SELECTIVE FOR NEUROTENSIN 2 RECEPTOR
    Publication number: 20170174633
    Abstract: This invention relates generally to the discovery of pyrazole compounds selective for the neurotensin receptor 2 (NTR2) and uses thereof.
    Type: Application
    Filed: March 24, 2015
    Publication date: June 22, 2017
    Inventors: James B. THOMAS, Brian P. GILMOUR, Angela M. GIDDINGS, Robert W. WIETHE, Keith R. WARNER, Srinivas OLEPU