Abstract: A footwear sole structure may include a plurality of discrete hexagonally-shaped sole elements defined by a plurality of sipes. The sipes may include a plurality of sipes that extend in a transverse direction across the sole structure and a plurality of sipes that extend in an oblique direction relative to the transverse sipes. A plurality of sipes may also subdivide the hexagonally-shaped sole elements into one or more diamond-shaped sole element portions. The sole structure may include additional features such as non-hexagonal sole elements and lugs distributed across a bottom surface of the sole structure.

Abstract: A footwear sole structure may include a plurality of discrete hexagonally-shaped sole elements defined by a plurality of sipes. The sipes may include a plurality of sipes that extend in a transverse direction across the sole structure and a plurality of sipes that extend in an oblique direction relative to the transverse sipes. A plurality of sipes may also subdivide the hexagonally-shaped sole elements into one or more diamond-shaped sole element portions. The sole structure may include additional features such as non-hexagonal sole elements and lugs distributed across a bottom surface of the sole structure.

Abstract: A method for forming a guide for a top drive unit includes connecting a lower track member to a lower mast section and connecting an upper track member to an upper mast section and telescoped with the lower track section. A slider is slidably positioned about the upper track member so the slider is movable along the upper track member. The slider has a lateral cross-sectional profile substantially the same size and shape as a lateral cross-sectional profile of the lower track member. The skate is slidably positioned about the lower track member to be movable along the lower track member and onto the slider. The skate travels along the upper track member via the slider. The skate is connectable to a top drive unit so the top drive unit is movable along the lower track member and the upper track member.

Abstract: The invention is an apparatus used to send sound exterior to the vehicle to a location on the interior of a vehicle which corresponds with the sound’s external location. The apparatus adjusts for gain by frequency and shifts frequencies of the audio signals received exterior to the vehicle to generate a modified audio signal. The adjustments include compensation for hearing loss, compensation for audio in the interior of the vehicle, and attenuation adjustments for unwanted exterior noise. The modified audio signal is generated by filtering unwanted audio from the exterior audio, adjusting for gain by frequency and shifting/compressing frequencies according to hearing deficiencies, and adjusting for gain by frequency according to audio in the interior of the vehicle. The modified audio signal may be limited to a maximum gain and then amplified in the interior of the vehicle.

Abstract: The invention relates to cell sampling devices. In particular, the present invention relates to ingestible cell sampling devices for sampling cells in a subject, and methods of use for detecting abnormalities in a subject using the same.

Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Abstract: Genome edited plants, plant cells, seeds and plant parts of Brassica are provided where expression levels and/or activities of pod dehiscence genes are modulated to improve one or more agronomic characteristics such as pod shatter. Also provided are compositions comprising polynucleotides encoding polypeptides and guide RNAs targeted to endogenous Brassica proteins involved in pod dehiscence including for example, targeted site-directed mutagenesis using CRISPR-associated nucleases. Additionally, various methods of employing the polynucleotides and genetic modifications in plants, such as methods for modulating expression level in a Brassica plant and methods for increasing pod shatter tolerance of a Brassica plant are also provided herein.

Abstract: Methods and compositions for identifying novel genes useful for modulating desired agronomic traits in plants are presented herein. The present disclosure relates to methods for identifying line-specific and cluster-specific genes from plants that show perturbation of expression in response to perturbation of expression of a primary gene, and the perturbation of expression of the line-specific or cluster-specific gene confers alterations in agronomic characteristics upon the plant.

Abstract: Compositions and methods for editing an endogenous NAC genes in plants are provided, for the improvement of traits of agronomic or commercial importance. Modifications of expression and activity of NAC genes are described, including editing endogenous NAC gene functional motifs and knocking out NAC gene function.

Abstract: Provided are compositions comprising polynucleotides encoding glutamine synthetase (GS) polypeptides having improved properties, such as increased enzymatic activity and/or increased thermostability. Also provided are recombinant DNA constructs, plants, plant cells, seed, grain comprising the polynucleotides. Additionally, various methods of employing the polynucleotides in plants, such as methods for increasing GS activity in a plant, methods for increase seed protein content in a seed of a plant, and methods for increasing yield of a plant, are also provided herein.

Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a PRE2 polypeptide.

Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring stress tolerance are presented herein, along with compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a DTP4 polypeptide.

Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a RING-H2 polypeptide.

Abstract: Isolated polynucleotides, polypeptides and recombinant DNA constructs useful for conferring drought tolerance are disclosed. The recombinant DNA construct comprises a promoter that is functional in a plant operably linked to a polynucleotide that encodes a PAP, a DTP25 or a DTP46 polypeptide. Also disclosed are methods of utilizing the recombinant DNA construct and compositions (such as plants or seeds) comprising the recombinant DNA construct.

Abstract: A compact dual-output speed-reduction mechanism for oil well pumps includes a housing containing a chamber; a high-speed tubular input shaft having a first end portion journalled in a first housing opening, and an eccentric portion arranged in the housing chamber; a low-speed output shaft journalled within the input shaft, the output shaft having a first end portion extending outwardly of the housing beyond the input shaft first end portion, and a second end portion that extends beyond the input shaft second end portion and outwardly of the housing via a second housing opening opposite the first housing opening. A cycloidal speed-reduction mechanism arranged in the housing chamber is connected between the input shaft eccentric portion and the housing, and between the input shaft eccentric portion and a power transfer disk connected with the output shaft. At least one rotatably-driven device is connected with the two output shaft end portions.

Abstract: The present invention provides for methods, processes and platforms to validate systems genetics networks to define their genetic regulators and to optimize translational applicability to humans for drug development. These systems genetics networks are sets of genes with a common function that demonstrate covariate expression that is genetically modulated by linked function network regulators (LFNRs) which comprise eQTLs in animals and GWAS SNPs in humans. LFNRs represent a new class of targets to identify drugs to prevent, ameliorate, and/or treat human diseases. LFNRs for the cell cycle-mitosis network have potential to be especially useful for anti-cancer therapies. The present invention provides for a drug that targets a specific LFNR for the cell cycle-mitosis network in Caucasian male liver to prevent the development of hepatocellular carcinoma in high risk patient populations.

Abstract: A speech recognition system includes a natural language processing component and an automated speech recognition component distinct from each other such that uncertainty in speech recognition is isolated from uncertainty in natural language understanding, wherein the natural language processing component and an automated speech recognition component communicate corresponding weighted meta-information representative of the uncertainty.

Abstract: Disclosed is a method and system for the use of virtual robots (Bots) to assist in the answering of inquiries from persons over the Internet, telephone, wireless, or other form of electrical, digital, or electronic communication. Such method and system consists of (1) a Bot processor consisting of (a) a connection interface capable of receiving, directly or indirectly, inputs from a user in natural or machine language, which the Bot processor then responds to in natural or machine language, and (b) an engine capable of recognizing an input and providing a response; and (2) a service desk consisting of (a) a human being, (b) a connection interface that connects directly or indirectly to the Bot processor and to the front end, and (c) a display where the human being can see, in humanly comprehensible form, information transmitted by the user and/or the Bot processor.

Abstract: The present application relates to a marine buoy featuring a novel bracing assembly disposed within a marine buoy and featuring a plurality of bracing members extending between and connecting to a first fastening member and a second fastening member.

Abstract: In one embodiment, a method for selecting transistor threshold voltages on an integrated circuit may include assigning a first threshold voltage to selected groups of transistors such as cell instances, for example, and determining which of the selected groups of transistors to assign a second threshold voltage, that is lower than the first threshold voltage, by iteratively performing a cost/benefit analysis. The method may further include determining which of the selected groups of transistors having a third threshold voltage to assign the first threshold voltage by iteratively performing a cost/benefit analysis. The cost/benefit analysis may include calculating a cost/benefit ratio for each group of the selected groups of transistors. In addition, the cost/benefit analysis may include calculating an upcone benefit and a downcone benefit for groups of transistors coupled to one or more inputs and outputs, respectively.