Patents by Inventor Robert Wade Worsham

Robert Wade Worsham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS
    Publication number: 20240066277
    Abstract: Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity.
    Type: Application
    Filed: November 8, 2023
    Publication date: February 29, 2024
    Inventors: Joseph C. Trautman, Robert Wade Worsham, Parminder Singh, Guohua Chen
  • APPLICATORS FOR MICRONEEDLES
    Publication number: 20230277829
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Application
    Filed: May 16, 2023
    Publication date: September 7, 2023
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Applicators for microneedles
    Patent number: 11666740
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: June 6, 2023
    Assignee: Corium Pharma Solutions, Inc.
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY
    Publication number: 20230027289
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Application
    Filed: July 15, 2022
    Publication date: January 26, 2023
    Inventors: Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
  • Method and device for transdermal delivery of parathyroid hormone using a microprojection array
    Patent number: 11419816
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: August 23, 2022
    Assignee: Corium, Inc.
    Inventors: Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
  • Microprojection applicators and methods of use
    Patent number: 11110259
    Abstract: Applicators for a microprojection array and methods of using the applicators are described.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: September 7, 2021
    Assignee: Corium, Inc.
    Inventors: Anthony Le, Doug Bourne, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Microarray for delivery of therapeutic agent and methods of use
    Patent number: 11052231
    Abstract: Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 6, 2021
    Assignee: Corium, Inc.
    Inventors: Zhongli Ding, Guohua Chen, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • APPLICATORS FOR MICRONEEDLES
    Publication number: 20210187263
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Application
    Filed: February 25, 2021
    Publication date: June 24, 2021
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Applicators for microneedles
    Patent number: 10946180
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: March 16, 2021
    Assignee: Corium, Inc.
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY
    Publication number: 20200405630
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Application
    Filed: February 10, 2020
    Publication date: December 31, 2020
    Inventors: Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
  • MICROPROJECTION APPLICATORS AND METHODS OF USE
    Publication number: 20190184148
    Abstract: Applicators for a microprojection array and methods of using the applicators are described.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Anthony LE, Doug BOURNE, Ashutosh SHASTRY, Robert Wade WORSHAM, Parminder SINGH
  • SOLVENT-CAST MICROPROTRUSION ARRAYS CONTAINING ACTIVE INGREDIENT
    Publication number: 20190184147
    Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Parminder SINGH, Robert Wade WORSHAM, Joseph C. TRAUTMAN, Danir BAYRAMOV, Danny Lee BOWERS, Andrew Richard KLEMM, Steven Richard KLEMM, Guohua CHEN
  • Microprojection applicators and methods of use
    Patent number: 10245422
    Abstract: Applicators for a microprojection array and methods of using the applicators are described.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: April 2, 2019
    Assignee: Corium International, Inc.
    Inventors: Anthony Le, Doug Bourne, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Solvent-cast microprotrusion arrays containing active ingredient
    Patent number: 10238848
    Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: March 26, 2019
    Assignee: Corium International, Inc.
    Inventors: Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayamov, Danny Lee Bowers, Andrew Richard Klemm, Steven Richard Klemm, Guohua Chen
  • Microarray for delivery of therapeutic agent, methods of use, and methods of making
    Patent number: 9962534
    Abstract: Devices and methods for using and manufacturing microstructure arrays are described.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 8, 2018
    Assignee: Corium International, Inc.
    Inventors: Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • APPLICATORS FOR MICRONEEDLES
    Publication number: 20170361079
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Application
    Filed: June 26, 2017
    Publication date: December 21, 2017
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY
    Publication number: 20170281535
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Inventors: Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
  • Method and device for transdermal delivery of parathyroid hormone using a microprojection array
    Patent number: 9687641
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 27, 2017
    Assignee: Corium International, Inc.
    Inventors: Parminder Singh, Danir Bairamov, Guohua Chen, Robert Wade Worsham
  • Applicators for microneedles
    Patent number: 9687640
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 27, 2017
    Assignee: Corium International, Inc.
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Method of vaccine delivery via microneedle arrays
    Patent number: 9498524
    Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: November 22, 2016
    Assignee: Corium International, Inc.
    Inventors: Esi Ghartey-Tagoe, Janet Wendorf, Steve Williams, Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andrew Richard Klemm, Steven Richard Klemm, Guohua Chen