Patents by Inventor Robert Wade Worsham

Robert Wade Worsham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190184147
    Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Parminder SINGH, Robert Wade WORSHAM, Joseph C. TRAUTMAN, Danir BAYRAMOV, Danny Lee BOWERS, Andrew Richard KLEMM, Steven Richard KLEMM, Guohua CHEN
  • Publication number: 20190184148
    Abstract: Applicators for a microprojection array and methods of using the applicators are described.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Anthony LE, Doug BOURNE, Ashutosh SHASTRY, Robert Wade WORSHAM, Parminder SINGH
  • Patent number: 10245422
    Abstract: Applicators for a microprojection array and methods of using the applicators are described.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: April 2, 2019
    Assignee: Corium International, Inc.
    Inventors: Anthony Le, Doug Bourne, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Patent number: 10238848
    Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: March 26, 2019
    Assignee: Corium International, Inc.
    Inventors: Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayamov, Danny Lee Bowers, Andrew Richard Klemm, Steven Richard Klemm, Guohua Chen
  • Patent number: 9962534
    Abstract: Devices and methods for using and manufacturing microstructure arrays are described.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 8, 2018
    Assignee: Corium International, Inc.
    Inventors: Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Publication number: 20170361079
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Application
    Filed: June 26, 2017
    Publication date: December 21, 2017
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Publication number: 20170281535
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Inventors: Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
  • Patent number: 9687640
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 27, 2017
    Assignee: Corium International, Inc.
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Patent number: 9687641
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 27, 2017
    Assignee: Corium International, Inc.
    Inventors: Parminder Singh, Danir Bairamov, Guohua Chen, Robert Wade Worsham
  • Patent number: 9498524
    Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: November 22, 2016
    Assignee: Corium International, Inc.
    Inventors: Esi Ghartey-Tagoe, Janet Wendorf, Steve Williams, Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andrew Richard Klemm, Steven Richard Klemm, Guohua Chen
  • Patent number: 9452280
    Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: September 27, 2016
    Assignee: Corium International, Inc.
    Inventors: Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen
  • Publication number: 20150297878
    Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
    Type: Application
    Filed: July 1, 2015
    Publication date: October 22, 2015
    Inventors: Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andrew Richard Klemm, Steven Richard Klemm, Guohua Chen
  • Patent number: 9114238
    Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: August 25, 2015
    Assignee: Corium International, Inc.
    Inventors: Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen
  • Publication number: 20150079133
    Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
    Type: Application
    Filed: November 20, 2014
    Publication date: March 19, 2015
    Inventors: Esi Ghartey-Tagoe, Janet Wendorf, Steve Williams, Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andrew Richard Klemm, Steven Richard Klemm, Guohua Chen
  • Patent number: 8911749
    Abstract: A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: December 16, 2014
    Assignee: Corium International, Inc.
    Inventors: Esi Ghartey-Tagoe, Janet Wendorf, Steve Williams, Parminder Singh, Robert Wade Worsham, Joseph C. Trautman, Danir Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen
  • Publication number: 20140276580
    Abstract: Applicators for a microprojection array and methods of using the applicators are described.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Applicant: CORIUM INTERNATIONAL, INC.
    Inventors: Anthony Le, Doug Bourne, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Publication number: 20140272101
    Abstract: Devices and methods for using and manufacturing microstructure arrays are described.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Corium International, Inc.
    Inventors: Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Patent number: 8821446
    Abstract: A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: September 2, 2014
    Assignee: Corium International, Inc.
    Inventors: Joseph C. Trautman, Robert Wade Worsham, Danir F. Bayramov, Danny Lee Bowers, Steven Richard Klemm, Parminder Singh
  • Publication number: 20140180201
    Abstract: Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicant: CORIUM INTERNATIONAL, INC.
    Inventors: Zhongli Ding, Guohua Chen, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Publication number: 20130292886
    Abstract: Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity.
    Type: Application
    Filed: July 9, 2013
    Publication date: November 7, 2013
    Inventors: Appala Sagi, Joseph C. Trautman, Guohua Chen, Robert Wade Worsham, Parminder Singh