Abstract: An apparatus for measuring a sidewall characteristic of a wound roll includes a housing, a platform mounted in the housing having a surface adapted to receive the wound roll, a distance measuring sensor supported in the housing for movement along a predetermined line of measurement extending across at least a portion of the sidewall of the wound roll for measuring the sidewall characteristic, and a processor for processing the sidewall characteristic and generating at least one quality metric representative of the quality of the roll.

Abstract: A method is provided for adjusting color output in a digital press. The method comprises providing a digital press including a output color ink array configured to print a first spot color element on a media and including an input color array including a process color subarray and at least one custom color input. The first spot color element is printed on the media from the digital press via a spot color simulation of the at least one custom color input using the output color ink array. The first spot color element is adjusted by modifying, at the digital press, the at least one custom color input without adjusting the process color subarray of the input color array.

Abstract: A method for automatically generating a color separation at a digital press comprises defining a color ink array of n-color inks. A separation model is constructed at the digital press based on parameters of the digital press and ink parameters of each of the n-color inks. The constructed separation model is applied to an input digital file to enable printing an element of the input digital file using the n-color inks.

Abstract: A method for registering patterns on a web to provide independent scale control in both the lateral and longitudinal directions is provided. The method includes routing the web over a first roller; routing the web over a second roller and stabilizing the web; applying a pattern to the web using process hardware; measuring registration of the pattern and providing an error signal; controlling lateral position error using the error signal; controlling longitudinal position error using the error signal; controlling lateral scale error using the error signal; and controlling longitudinal scale error using the error signal. The method provides independent scale control in both the lateral and longitudinal directions. Independent scale control avoids non-linear distortions otherwise imposed by attempting to accomplish both corrections by stretching the web in both directions.

Abstract: The present invention relates to a method of conditioning a support comprising continuously providing a support, applying an interleaving material to at least one side of the support, wherein the interleaving material produces a continuous gap between the opposite side of the support having applied interleaving material and the side of the support having applied interleaving material when the support is wound, and conditioning the support.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase inhibitory activity.

Abstract: The present invention generally relates to polymer films and a process for forming a polarizer plate comprising supplying cover sheets on carrier webs, peeling the cover sheet from the carrier webs, spreading the cover sheets, and laminating the cover sheets to a polarizing film. The process may further comprise means for improved tension control, static dissipation after peeling the cover sheet from the carrier web, and an accumulator after a double splicing operation for splicing expiring web to fresh web.

Abstract: The present invention generally relates to polymer films and a process for forming a polarizer plate comprising supplying one or more cover sheets on carrier webs, peeling the cover sheet from the carrier webs, spreading the cover sheets, and laminating the cover sheets to a polarizing film. The process may further comprise tension control, static dissipation after peeling the cover sheet from the carrier web, and an accumulator after a double splicing operation for splicing expiring web to fresh web.

Abstract: A method for registering patterns on a web comprises attaching a backing material to a web and stabilizing the web; routing the web over one or more sets of rollers; applying a pattern to the web; and removing the backing material. Patterning can be applied at a set of rollers or between rollers along the path of the web. The backing material has indicia thereon for use in registration of the patterns applied to the web. Using the method, a steel backing material can be applied with an adhesive to a polyethylene terephthalate web material.

Abstract: A method for registering patterns on a web to provide independent scale control in both the lateral and longitudinal directions is provided. The method comprises routing the web over a first roller; routing the web over a second roller and stabilizing the web; applying a pattern to the web using process hardware; measuring registration of the pattern and providing an error signal; controlling lateral position error using the error signal; controlling longitudinal position error using the error signal; controlling lateral scale error using the error signal; and controlling longitudinal scale error using the error signal. The method provides independent scale control in both the lateral and longitudinal directions. Independent scale control avoids non-linear distortions otherwise imposed by attempting to accomplish both corrections by stretching the web in both directions.

Abstract: A web conveyance system is provided for conveying a web that has first and second edge portions and a central portion disposed between the first and second edge portions. The web conveyance system has means for engaging the first and second edge portions of the web and maintaining the central portion of the web free of contact with the means. Preferably, the means comprises a roller with left and right end portions and an undercut middle portion. The end portions of the roller engage side edge portions of the web for conveyance while the middle portion of the web and roller remain free of contact with the roller.

Abstract: The invention provides a process for the production of a compound of formula (A), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, and R4 are as defined herein.

Abstract: The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

Abstract: 1

Abstract: The present invention relates to a novel process for producing quinazoline compounds which are useful in therapy. More specifically, the compounds are useful in the treatment of benign prostatic hyperplasia.

Abstract: The invention provides a process for the production of a compound of formula (A) or a pharmaceutically acceptable salt or solvate thereof: which comprises condensing a compound of formula (B) with a compound of formula (C): Compounds of formula (A) are useful in the treatment of benign prostatic hyperplasia.

Abstract: The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

Abstract: The invention provides a process for the production of a compound of formula (A), or a pharmaceutically acceptable salt or solvate thereof, 1

Abstract: The invention provides a process for the production of a compound of formula (A) or a pharmaceutically acceptable salt or solvate thereof: 1

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase inhibitory activity.