Patents by Inventor Robert Wardle

Robert Wardle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20250049756
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: October 29, 2024
    Publication date: February 13, 2025
    Inventors: Mark D. BEDNARSKI, Susan KNOX, Louis CANNIZZO, Kirstin WARNER, Robert WARDLE, Stephen VELARDE, Shoucheng NING
  • Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
    Patent number: 11925617
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: March 12, 2024
    Assignees: NORTHROP GRUMMAN SYSTEMS, CORPORATION and EPICENTRX, INC.
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20220016077
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: February 26, 2021
    Publication date: January 20, 2022
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20200046682
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: March 14, 2019
    Publication date: February 13, 2020
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
    Patent number: 10149832
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: December 11, 2018
    Assignees: EpicentRx, Inc., Orbital ATK, Inc.
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20180085346
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: August 4, 2017
    Publication date: March 29, 2018
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20160199346
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: December 10, 2015
    Publication date: July 14, 2016
    Inventors: MARK D. BEDNARSKI, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
    Patent number: 9226915
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: January 5, 2016
    Assignees: EPICENTRX, INC., ORBITAL ATK, INC.
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20150246020
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: December 29, 2014
    Publication date: September 3, 2015
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
    Patent number: 8927527
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: January 6, 2015
    Assignees: EpicentRx, Inc., Alliant Techsystems Inc.
    Inventors: Mark D. Bednarski, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • Acyclic organonitro compounds for use in treating cancer
    Patent number: 8664247
    Abstract: The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: March 4, 2014
    Assignees: RadioRx, Inc., Alliant Techsystems Inc.
    Inventors: Jan Scicinski, Bryan T. Oronsky, Robert Wardle, Louis Cannizzo, Nicholas A. Straessler
  • ACYCLIC ORGANONITRO COMPOUNDS FOR USE IN TREATING CANCER
    Publication number: 20130053418
    Abstract: The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 28, 2013
    Inventors: Jan Scicinski, Bryan T. Oronsky, Robert Wardle, Louis Cannizzo, Nicholas A. Straessler
  • Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
    Patent number: 8299053
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: October 30, 2012
    Assignees: RadioRx, Inc., Alliant Techsystems Inc.
    Inventors: Mark D. Bednarski, Lynn M. Oehler, legal representative, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • PHARMACEUTICAL COMPOSITIONS OF O-NITRO COMPOUNDS
    Publication number: 20120237615
    Abstract: The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: May 30, 2012
    Publication date: September 20, 2012
    Applicants: RADIORX, INC., C/O INTERWEST VENTURE PARTNERS, ALLIANT TECHSYSTEMS INC.
    Inventors: Mark D. Bednarski, Lynn M. Oehler, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20090163466
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: March 4, 2009
    Publication date: June 25, 2009
    Applicants: RadioRx, Inc., Alliant Techsystems Inc.
    Inventors: Mark D. Bednarski, Lynn M. Oehler, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning
  • Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
    Patent number: 7507842
    Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: March 24, 2009
    Assignees: RadioRx, Inc., Alliant Techsystems Inc.
    Inventors: Lynn M. Oehler, legal representative, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning, Mark D. Bednarski
  • METHOD OF FORMULATING A FUEL COMPOSITION
    Publication number: 20080104883
    Abstract: In a fuel composition containing a static dissipator additive, a Fischer-Tropsch derived fuel component is blended for the purpose of increasing the electrical conductivity of the composition and/or for reducing the concentration of the static dissipator additive in the composition. The fuel composition is preferably an automotive diesel fuel composition.
    Type: Application
    Filed: October 18, 2007
    Publication date: May 8, 2008
    Inventors: Claire Ansell, Richard Clark, Robert Wardle
  • FUEL COMPOSITIONS
    Publication number: 20080033220
    Abstract: A method for increasing the cetane number of a fuel composition containing a Fischer-Tropsch derived fuel component, in order to reach a target cetane number X, is provided by adding to the composition a concentration c of an ignition improver, wherein c is lower than the concentration which theory would predict needed to be added in order to achieve the target. The ignition improver is preferably 2-ethylhexyl nitrate and the fuel composition suitably a diesel or kerosene fuel. A fuel composition for use in a compression ignition engine, which has a cetane number of 85 or greater, and contains a Fischer-Tropsch derived fuel component and an ignition improver is also disclosed.
    Type: Application
    Filed: June 26, 2007
    Publication date: February 7, 2008
    Inventors: Richard Clark, Richard Stradling, Robert Wardle
  • FUEL COMPOSITION
    Publication number: 20070205137
    Abstract: A composition having a density at 15° C. of between 820 and 845 kg/m3 and a cetane number of equal or greater than 40, which composition has been obtained by blending the following components: (a) a cracked gas oil, (b) a mineral derived gas oil other than (a), and (c) a Fischer-Tropsch derived kerosene fraction; and the use of this composition as an automotive gas oil fuel composition.
    Type: Application
    Filed: December 21, 2006
    Publication date: September 6, 2007
    Inventors: Richard Clark, Richard Heins, Robert Wardle
  • O-nitro compounds, pharmaceutical compositions thereof and uses thereof
    Publication number: 20070135380
    Abstract: The present invention provides O-nitro compound, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
    Type: Application
    Filed: August 11, 2006
    Publication date: June 14, 2007
    Applicants: RadioRx, Inc., Alliant Techsystems Inc.
    Inventors: Mark Bednarski, Lynn Oehler, Susan Knox, Louis Cannizzo, Kirstin Warner, Robert Wardle, Stephen Velarde, Shoucheng Ning