Abstract: A blade for a turbine engine with a wall separating a cooling fluid flow and a hot gas fluid flow and having a heated surface along which the hot gas fluid flow flows and a cooled surface facing the cooling fluid flow. A plurality of cooling holes each having a passage extending between an inlet at the cooled surface and an outlet at the heated surface. The outlet extending between an upstream end and a downstream end with respect to the hot gas fluid flow to define a distance, the passage defining a centerline forming a first angle (?) with the heated surface.

Abstract: A hub is configured to provide voice control without assistance from a remote system, which allows the hub to provide a user with the ability to control second devices in an environment by issuing voice commands, even when the hub is unable to communicate with the remote system over a wide area network (e.g., the Internet). The hub is also configured to execute rules without assistance from the remote system, which allows the hub to execute rules, even when the hub is unable to communicate with the remote system over a wide area network (e.g., the Internet).

Abstract: This disclosure relates to a magnetorheological (MR) brake. The MR brake includes a rotor constructed at least partially of a ferromagnetic material, and a housing that supports the rotor such that the rotor and the housing are rotatable relative to each other about an axis, wherein the housing and rotor are configured such that a fluid gap is defined between the housing and the rotor, and wherein portions of the housing adjacent the rotor are constructed at least partially of a ferromagnetic material. An MR fluid is disposed in the fluid gap. A current-carrying coil is excitable to generate a magnetic field within ferromagnetic portions of the rotor and the housing and acts on the MR fluid. At least one element constructed of a material having low magnetic permeability is configured route the lines of magnetic flux through surrounding higher permeability material on opposite sides of the fluid gap.

Abstract: A surgical system, method, and apparatus for suturing a first anatomical structure to a second anatomical structure of a subject includes an endoscope tube for being advanced through a lumen of the first anatomical structure to a surgical site near the second anatomical structure. A manipulator arm extends through the endoscope tube to the surgical site, and includes a first concentric tube manipulator with an end effector configured to grasp and manipulate a suture at the surgical site. A needle arm extends through the endoscope tube to the surgical site, and includes a second concentric tube manipulator with a needle tip configured to pierce the tissue of the first and second anatomical structures. The needle arm is also configured to grasp the suture and to retract and pull the suture through the pierced tissue so that the suture extends through and forms stitching that stitches together the first and second anatomical structures.

Abstract: Movement of an autonomously motile device may be controlled by a user device. The user device may display image data captured by a camera of the autonomously motile device; a user may provide input, such as a touch gesture on a display screen, indicating a command for the autonomously motile device to move to a location indicated by the input. The autonomously motile device determines a coordinate of the input and a time of the touch input; the autonomously motile device then determines a direction and distance of a corresponding movement.

Abstract: The present invention provides a novel isolated succinate prodrug as the free compound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: The disclosure provides an apparatus and mechanism for and elevator safety mechanism. The safety mechanism can include a lock bar, a beak assembly, a detector assembly, and a linkage rod providing communication between the beak assembly and the detector assembly. The beak of the beak assembly can engage a catch in the lock bar when the safety mechanism is in a closed position, preventing the doors of the elevator from further opening.

Abstract: An autonomous mobile device (AMD) uses sensors to explore a physical space and determine the locations of obstacles. Simultaneous localization and mapping (SLAM) techniques are used by the AMD to designate as keyframes some images and their associated descriptors of features in the space. Each keyframe indicates a location and orientation of the AMD relative to those features. Anchors are specified relative to keyframes. A marker is specified relative to one or more anchors. Because markers are associated with features in the physical space, they maintain their association with the physical space through various processes such as SLAM loop closures. Markers may specify locations in the physical space, such as navigation waypoints, navigation destinations such as a goal pose for exploring an unexplored area, as an observation target to facilitate exploration, and so forth. Markers may also be used to specify block listed locations to be avoided during exploration.

Abstract: An autonomous mobile device (AMD) moves through a physical space without human intervention. Data from sensors on the AMD are used to determine an occupancy map indicative of obstacles and their locations in the physical space. A navigation map is created from the occupancy map by inflating the apparent size of the obstacles indicated by the occupancy map. In one implementation the inflation process dynamically skips some portions of the occupancy map based on the presence of an obstacle and a designated inflation distance. The extent of the inflation is based on a size of the AMD. The navigation map is then used for path planning.

Abstract: A robot comprises a plurality of sensors on a mobile chassis and may move about an environment in which people may be expected to follow particular cultural conventions. Movement of the robot may be constrained to honor these cultural conventions that are appropriate for the people in the environment. For example, when the robot is used within the United States, the robot tends to move along the right-hand side of a hallway. In comparison, when the robot is used within Japan the robot tends to move along the left-hand side of the hallway. The cultural conventions may be implemented as one-way gates present at specified locations in an occupancy map of the environment. The gates have no physical presence in the environment, but have the effect of placing a constraint on where the robot is permitted to move.

Abstract: Movement of an autonomously motile device may be controlled by a user device. The user device may display image data captured by a camera of the autonomously motile device; a user may provide input, such as a touch gesture on a display screen, indicating a command for the autonomously motile device to move to a location indicated by the input. The autonomously motile device determines a coordinate of the input and a time of the touch input; the autonomously motile device then determines a direction and distance of a corresponding movement.

Abstract: An autonomous mobile device (AMD) moves through a physical space without human intervention. Data from sensors on the AMD is used to determine an occupancy map indicative of obstacles and their locations in the physical space. Obstacles may be static, variable, or dynamic. For example, walls are static, doors which open and close are variable, and people moving through the environment are dynamic. Regions in the occupancy map that the AMD has visited but which are shown by the occupancy map as containing obstacles are identified as being variable regions. To determine possible paths through the physical space during autonomous movement, the variable regions are considered to be unoccupied by obstacles and traversable. Information about how often the variable region transitions between traversable and impassible states may also be used to determine the possible paths.

Abstract: Self-driving surface antigen-regulated promoter-therapeutic payload constructs containing antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the surface antigen-regulated promoter-therapeutic payload constructs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making self-driving surface antigen-regulated promoter-therapeutic payload constructs in T-cells are also disclosed.

Abstract: The present invention provides a novel isolated succinate prodrug as the free com-pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is useful in the medical treatment of a range of diseases, in nutritional supplements, nutricosmetics and in cosmetics.

Abstract: A point cloud or map of an environment is generated by determining sets of landmark points from multiple images, such as through use of a Simultaneous Localization and Mapping (SLAM) algorithm. Images acquired using a depth camera are used to determine depth points indicative of at least one object not represented by the landmark points. A combined map is generated to include both the landmark points and the depth points. The set of depth points is mapped to a corresponding set of landmark points based on proximity of the points, similarity of the camera poses, or times that the images were acquired. The relationship between the depth and landmark points may be determined. When the landmark points are moved, such as to account for error in the SLAM algorithm, the depth points may be moved to a modified location relative to the landmark points so that the relationship remains constant.

Abstract: This disclosure relates to a magnetorheological (MR) brake. The MR brake includes a rotor constructed at least partially of a ferromagnetic material, and a housing that supports the rotor such that the rotor and the housing are rotatable relative to each other about an axis, wherein the housing and rotor are configured such that a fluid gap is defined between the housing and the rotor, and wherein portions of the housing adjacent the rotor are constructed at least partially of a ferromagnetic material. An MR fluid is disposed in the fluid gap. A current-carrying coil is excitable to generate a magnetic field within ferromagnetic portions of the rotor and the housing and acts on the MR fluid. At least one element constructed of a material having low magnetic permeability is configured route the lines of magnetic flux through surrounding higher permeability material on opposite sides of the fluid gap.

Abstract: A robotic assistant comprises a plurality of sensors on a mobile chassis. An occupancy map includes obstacle cost values for particular areas or cells of the map. These obstacle cost values may be based on whether an obstacle is detected and the confidence value of that detection, estimated precision of the location of the detected object, and so forth. A set of rules for preferred locations of robot movement is used to assess the occupancy map and to determine constraint cost value for the particular areas. For example, the area in a center of a hallway may be associated with a relatively high constraint cost value. An aggregate cost value may be calculated by summing the obstacle cost value and the constraint cost value for the particular area. The aggregate cost value may be used to determine a maximum permissible speed for the robot while traversing the particular area.

Abstract: One aspect of the present disclosure includes a sheath configured to receive an ablation probe. The sheath includes a temperature-controlled anchor element thereon configured to attach the sheath to bodily tissue.

Abstract: This disclosure provides crystalline forms of a ? receptor agonist, and methods of making and using these forms.