Abstract: The invention provides methods of identifying an E-SYT2 modulator. The methods may comprise providing a cell that expresses E-SYT2; contacting the cell with a candidate chemical entity; and characterizing recruitment of at least one of Carma1, BcllO, NEMO, and PKC9 to the immunological synapse (IS). The invention also provides E-SYT2 modulators, including inhibitors, identified using the disclosed methods. The invention provides methods of inhibiting NF-?B activity in a cell comprising contacting the cell with an E-SYT2 inhibitor. The invention provides methods comprising providing a sample from a patient suspected of having or at risk of having a MALT-lymphoma or an ABC-DLBCL-lymphoma; and screening the sample to identify the presence and/or absence of a gain of function E-Syt2 mutation in the sample. The invention also provides genetically modified mammals comprising one or two loss of function alleles of E-Syt2.

Abstract: A cable grasping tool for grasping brake and derailleur cables includes a pair of handles that is rigid. The handles are pivotally coupled and arcuate, such that the handles are opposing. Each of a pair of jaws is coupled to and extends from a first end of a respective handle. Each of a plurality of grasps is coupled to an inner edge of a respective jaw. The grasps are configured to selectively couple a brake cable and a derailleur cable of a velocipede. The handles are positionable with the jaws in an open configuration, such that a cable is insertable between the jaws. The handles are configured for inward pivoting by action of a user's hand, such that the plurality of grasps engage the cable and facilitate manipulation of the cable by the user.

Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-?B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-?B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-?B, methods of detecting modulator of NF-?B using the antibodies, methods of treatment associated with NF-?B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-?B.

Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-?B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-?B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-?B, methods of detecting modulator of NF-?B using the antibodies, methods of treatment associated with NF-?B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-?B.

Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-?B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-?B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-?B, methods of detecting modulator of NF-?B using the antibodies, methods of treatment associated with NF-?B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-?B.

Abstract: The invention described herein is an externally mounted speaker grill with special features for dispersing full range sound at broad angles. The basic form of the invention consists of a speaker grill for protecting a speaker from the elements, a rounded cone shaped feature for dispersing high-frequency sound waves at broad angles, a series of spoke features for supporting the cone feature while allowing full range sound waves to pass largely unhindered, and mounting holes for screws to affix the speaker grill to the front of a speaker mounting board in front of a speaker.

Abstract: The invention described herein is an external telephone accessory for the purpose of placing a call in an on-hold state while simultaneously providing the caller on hold with music from a CD player, mp3 player, computer sound card, or other external audio source. The basic form of the invention consists of a housing having a pushbutton switch to mechanically switch the telephone signal and activate an LED to indicate the on-hold state, input and output modular telephone jacks, and an input jack for the audio source.

Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-&kgr;B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-&kgr;B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-&kgr;B, methods of detecting modulator of NF-&kgr;B using the antibodies, methods of treatment associated with NF-&kgr;B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-&kgr;B.

Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-&kgr;B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-&kgr;B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-&kgr;B, methods of detecting modulator of NF-&kgr;B using the antibodies, methods of treatment associated with NF-&kgr;B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-&kgr;B.

Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-&kgr;B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-&kgr;B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-&kgr;B, methods of detecting modulator of NF-&kgr;B using the antibodies, methods of treatment associated with NF-&kgr;B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-&kgr;B.