Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: A frozen pizza preparation package and method includes a prebaked frozen pizza, microwave-crisping sequence instructions that instruct sequential steps of heating the prebaked frozen pizza in a microwave oven followed by crisping the crust using a crisping appliance, and a unifying container incorporating the prebaked frozen pizza and the sequence instructions.

Abstract: A movable cart that provides entertainment. The present invention may include a housing with wheels. The housing may include a rechargeable battery that powers at least one speaker system mounted to the housing. The housing may further include multiple outlets to plug in other equipment, such as laptops, tablets, mixers and the like. The equipment may be connected to and play audio using the speakers.

Abstract: The present invention provides improved systems and methods for facilitating cuts in an item. In one embodiment, a surgical apparatus is provided that includes a first saw guide having a first base portion with a first bore and a first guide portion comprising a pair of substantially parallel walls spaced apart to guide the surgical saw; a second saw guide pivotably connected to the first saw guide, wherein the second saw guide includes a second base portion with a second bore and a second guide portion comprising a pair of substantially parallel walls spaced apart to guide the surgical saw; and a locking mechanism configured to selectively discourage relative movement between the first saw guide and the second saw guide.

Abstract: A method for secondary cardiovascular prevention in a patient includes formulating a single dosage unit containing a beta-adrenergic blocking agent and a cholesterol-lowering agent that is a statin where the single dosage unit contains a quantity of medications sufficient for secondary prevention of a heart attack in the patient, and administering the single dosage unit to the patient for secondary prevention of a heart attack. The method further includes the secondary prevention of a heart attack in a non-hypertensive patient.

Abstract: A seat belt buckle positioning system for use with a child booster seat having a seat belt buckle holder that can grasp or envelope a vehicle seat belt buckle, and a seat belt buckle holder positioner to which the seat belt buckle holder can attach and be positioned at the side of the child booster seat.

Abstract: An inhaler device to treat obstructive lung disease has an immediate acting bronchodilator medication, a dispenser housing for dispensing the immediate acting bronchodilator medication, and indicia on the dispenser housing to convey to a user that the inhaler device contains inhaler medication for for acute relief of obstructive lung disease symptoms.

Abstract: Embodiments of the present invention are generally related to the manipulation of a joint to provide therapy. More specifically, some embodiments of the present invention use inflatable members and a three point bending concept to cause flexion in a toe joint for the purpose of increasing the range of motion of the toe joint. In one embodiment, a user's foot is placed in a frame with at least one toe atop a toe bar. An inflatable member is positioned atop the user's foot and held in position with a strap attached relative to the frame. As the inflatable member is inflated, the strap increases in tension urging the toe toward the toe bar and causing actuation of the joint at the base of the toe.

Abstract: A drug for treating persistent cough occurring after an acute viral upper respiratory infection that has a corticosteroid aerosol for inhalation, and labeling to indicate short-term use of the agent for persistent post-viral cough. Also a method for treating persistent post-viral cough that utilizes such a drug.

Abstract: The present invention demonstrates that human parathyroid hormone 1-34 [hPTH(1-34)] exerts anti-apoptotic effects on osteoblasts when administered in an intermittent fashion to mice in vivo. The present invention further demonstrates that bovine PTH(1-34) [bPTH(1-34)] prevents glucocorticoid-induced apoptosis of osteoblastic and osteocytic cells in vitro. Therefore, the present invention demonstrates that the previously established anabolic effects of PTH on the skeleton are mediated by its ability to postpone osteoblast apoptosis, as opposed to a stimulatory effect on osteoblastogenesis. The present invention provides methods of screening agents for anti-apoptotic effects on osteoblasts, wherein such agents stimulate and/or restore bone in osteopenic individuals, or prevent bone loss caused by agents such as glucocorticoids.

Abstract: The invention as disclosed provides a method to increase bone mass without compromising bone strength or quality, through the administration to a host of a compound that binds to the estrogen or androgen receptor without causing hormonal transcriptional activation.

Abstract: A pharmaceutical dispensing kit that includes at least two different analgesic dosage units that have been formulated for use with each other, each of the analgesics being formulated for administration during a particular time of day and/or with relation to a particular event, the kit including a housing which contains said dosage units and which contains indicia identifying said dosage units and instructions coordinating use of the different dosage units together as a treatment regimen for pain. The dosage units may be packaged in bulk and distinguished by differences in geometry, size, markings, type of formulation (e.g., tablet versus soft gel capsule), and/or color, all types of indicia useful with this invention. A method for treating pain that uses the novel kit is also provided.

Abstract: A dispensing container which incorporates an aerosolizable topical insulin preparation, at least one oral hypoglycemic agent, and indicia and instructions for their coordinated use as a single therapeutic regimen for the treatment of diabetes mellitus in a human, and a method for treating diabetes mellitus which employs such a device.

Abstract: A pharmaceutical dispensing kit that includes at least two different analgesic dosage units that have been formulated for use with each other, each of the analgesics being formulated for administration during a particular time of day and/or with relation to a particular event, the kit including a housing which contains said dosage units and which contains indicia identifying said dosage units and instructions coordinating use of the different dosage units together as a treatment regimen for pain. The dosage units may be packaged in bulk and distinguished by differences in geometry, size, markings, type of formulation (e.g., tablet versus soft gel capsule), and/or color, all types of indicia useful with this invention. A method for treating pain that uses the novel kit is also provided.

Abstract: A device for the intranasal delivery of a medicament regimen to the nasal membranes for the treatment of such conditions as rhinitis.

Abstract: An inhaler device that is able to house multiple removable canisters of medication. The inhaler device may also have extendable and retractable outlet nozzles, spacer devices, a cover and assorted cap designs to ensure proper use of the device and application of the medication.

Abstract: A serum-free medium for use in propagating cells.A process involving growing normal mammalian cells in vitro in a serum-free medium. The process includes providing the cells to be grown with various hormones as well as required nutrients in a serum-free environment.