Patents by Inventor Robert William Clarke
Robert William Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20140336159Abstract: Described are methods of preventing, treating and diagnosing of a subject having a condition, such as, an inflammation or infection of the respiratory tract. Methods of treatment and prevention include administration of effective amounts of calcium salt formulations to a subject. Methods of diagnosing include the use of biomarkers and optionally the use of kits that can detect biomarkers. Further described are methods for modulating an immune response that include the modulation of Toll-like receptors.Type: ApplicationFiled: October 5, 2012Publication date: November 13, 2014Inventors: Robert William Clarke, David L. Hava, John P. Hanrahan, Wesley Hugh Dehaan, Paulette Wright Andreotta, Stephen P. Arold, Jennifer Kenyon Saunders
-
Patent number: 8627821Abstract: Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual.Type: GrantFiled: July 10, 2007Date of Patent: January 14, 2014Assignee: Pulmatrix, Inc.Inventors: David A. Edwards, Mark J. Gabrielson, Robert William Clarke, Wesley H. Dehaan, Matthew Frederick Brande, Jonathan Chun-Wah Man
-
Patent number: 7390918Abstract: An integrated process for the production of an alkenyl carboxylate, such as vinyl acetate which process comprises the steps of (a) contacting in an oxidation reaction zone a C2 to C4 alkane, such as ethane, a molecular oxygen-containing gas, optionally the corresponding alkene and optionally water, in the presence of a catalyst to produce a stream comprising alkene, carboxylic acid and water; (b) separating at least a portion of the stream from step (a) into a fraction comprising the alkene and a fraction comprising the carboxylic acid and water; (c) contacting in a second reaction zone at least a portion of said alkene fraction produced in step (b), a carboxylic acid and a molecular oxygen-containing gas, in the presence of a catalyst to produce a product stream comprising an alkenyl carboxylate, water and carboxylic acid; (d) separating at least a portion of the product stream from step (c) and at least a portion of the carboxylic acid and water fraction produced in step (b) by azeotropic distillation intoType: GrantFiled: December 4, 2002Date of Patent: June 24, 2008Assignee: BB Chemicals LimitedInventors: Robert William Clarke, Mark Stephen Roberts
-
Patent number: 7211688Abstract: Process for producing an alkyl carboxylate, comprising contacting in an oxidation reaction zone a C2 to C4 alkane, a molecular oxygen-containing gas, the corresponding alkene and optionally water, in the presence of at least one catalyst active for the oxidation of the alkane to the corresponding alkene and carboxylic acid, to produce a first product stream comprising alkene, unreacted alkane, carboxylic acid and water; separating in a first separation means at least a portion of the product stream produced in the oxidation reaction zone into a gaseous stream comprising alkene and unreacted alkane and a liquid stream comprising carboxylic acid and water; and separating by chemical treatment at least a portion of the gaseous stream obtained from the first separation means into respective streams rich in alkene and alkane; wherein the chemical treatment comprises the steps of: (1) contacting the alkene/alkane gaseous stream with a solution of a metal salt capable of selectively chemically absorbing the alkene tType: GrantFiled: February 12, 2003Date of Patent: May 1, 2007Assignee: BP Chemicals LimitedInventors: Robert William Clarke, Robert Croll, Andrew Richard Lucy, Bruce Leo Williams
-
Patent number: 6913734Abstract: A process and apparatus for contacting (a) at least one gaseous reactant and (b) at least one liquid selected from the group consisting of reactants, coolants and mixtures thereof in the presence of a fluidized bed of catalyst, in which the liquid is introduced into the reactor through at least one inlet located within the fluidization zone and the gaseous reactant is introduced into the reactor through at least one inlet located within the fluidization zone adjacent the support means.Type: GrantFiled: June 11, 2001Date of Patent: July 5, 2005Assignee: BP Chemicals LimitedInventors: Stanley John Becker, Timothy Crispin Bristow, Robert William Clarke, Michele Fiorentino, David Newton, Ian All Beattie Reid, Bruce Leo Williams
-
Publication number: 20020016374Abstract: A process and apparatus for contacting (a) at least one gaseous reactant and (b) at least one liquid selected from the group consisting of reactants, coolants and mixtures thereof in the presence of a fluidized bed of catalyst, in which the liquid is introduced into the reactor through at least one inlet located within the fluidization zone and the gaseous reactant is introduced into the reactor through at least one inlet located within the fluidization zone adjacent the support means.Type: ApplicationFiled: June 11, 2001Publication date: February 7, 2002Inventors: Stanely John Becker, Timothy Crispin Bristow, Robert William Clarke, Michele Fiorentino, David Newton, Ian Allan Beattie Reid, Bruce Leo Williams
-
Patent number: 6342628Abstract: In a process for production of vinyl acetate by the reaction of ethylene, acetic acid and oxygen, ethylene is recovered from the gases withdrawn from the reactor and recycled such that the amount of ethylene in the combined feed to the reactor is at least 60 mol %.Type: GrantFiled: July 29, 1999Date of Patent: January 29, 2002Assignee: BP Chemicals LimitedInventors: Bruce Leo Williams, Robert William Clarke, Timothy Crispin Bristow, Michael James Baker
-
Publication number: 20020006368Abstract: A reactor and process for using same, for containing a solid catalyst for heterogeneous gas-phase reactions into which reactor there extends at least one inlet pipe for a molecular oxygen-containing gas which has means for surrounding a substantial portion of the pipe in the reactor with an inert fluid and optionally also has means for suppressing ingress to the inlet pipe from the reactor of flame, reagents, products, catalyst or combinations thereof. The reactor and process are particularly suitable for fluid bed reactions.Type: ApplicationFiled: June 11, 2001Publication date: January 17, 2002Inventors: Stanley John Becker, Timothy Crispin Bristow, Robert William Clarke, Derek Alan Colman, David Newton, Ian Allan Beattie Reid, Bruce Leo Williams
-
Patent number: 6225496Abstract: Process for the production of vinyl acetate in which ethylene, acid and oxygen-containing gas are combined at elevated temperature in the presence of a catalyst material to produce (i) a product mixture comprising vinyl acetate, (ii) a liquid by-product comprising acetic acid and (iii) a gaseous by-product comprising carbon dioxide. The liquid by-product is separated from the product mixture and treated to reduce the water content therein before being recycled to the reactor such that the water entering the reactor comprises less than 6 wt %, (preferably less than 4 wt %, more preferably less than 3 wt %) of the total of acetic acid and water entering the reactor.Type: GrantFiled: July 29, 1999Date of Patent: May 1, 2001Assignee: BP Chemicals LimitedInventors: Michael James Baker, Timothy Crispin Bristow, Robert William Clarke, Simon James Kitchen, Bruce Leo Williams
-
Patent number: 3941785Abstract: Compounds of the general formula: ##SPC1##In which:R.sub.1 and R.sub.2 which may be the same or different, represent a hydrogen atom or an alkyl group which may optionally be substituted by an aryl group, or represents an alkanoyl, aroyl or alkanesulphonyl group;R.sub.3 represents a hydrogen atom, or an alkyl group which may optionally be substituted by an aryl group, or represents an alkenyl, aryl or alkylthio group;R.sub.4 represents a hydrogen atom or an alkyl group; andR.sub.5 represents a hydrogen atom or an aryl or alkyl group, which alkyl group may optionally be substituted by a cycloalkyl group;And physiologically acceptable salts and derivatives thereof and addition products formed by nucleophilic addition.These compounds act as spasmolytics and phosphodiasterase inhibitors and have cardiotonic and diuretic properties. They are also of use in the treatment of skin disorders and gout.Type: GrantFiled: December 26, 1973Date of Patent: March 2, 1976Assignee: Allen & Hanburys LimitedInventors: Robert William Clarke, David Hartley, Alexander William Oxford