Patents by Inventor Robert William Guthrie

Robert William Guthrie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaminopropionic acid derivatives
    Patent number: 7491741
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: February 17, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Diaminopropionic acid derivatives
    Patent number: 7217728
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: May 15, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • N-alkanoylphenylalanine derivatives
    Publication number: 20040210051
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 21, 2004
    Publication date: October 21, 2004
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • N-alkanoylphenylalamine derivatives
    Patent number: 6806365
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: October 19, 2004
    Assignee: Hoffmann-La Rocher Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Diaminopropionic acid derivatives
    Patent number: 6803384
    Abstract: A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusion injury.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: October 12, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Diaminopropionic acid derivatives
    Publication number: 20040006236
    Abstract: A compound of formula 1a 1
    Type: Application
    Filed: January 22, 2003
    Publication date: January 8, 2004
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • N-alkanoylphenylalamine derivatives
    Publication number: 20030109459
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 5, 2002
    Publication date: June 12, 2003
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Dehydroamino acids
    Patent number: 6515124
    Abstract: Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: February 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Dehydroamino acids
    Publication number: 20020161237
    Abstract: Compounds of formula 1 and 1-1, 1
    Type: Application
    Filed: January 5, 2001
    Publication date: October 31, 2002
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • N-alkanoylphenylalanine derivatives
    Patent number: 6455550
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: September 24, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Diaminopropionic acid derivatives
    Patent number: 6331640
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: December 18, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • N-aroylphenylalanine derivative VCAM-1 inhibitors
    Patent number: 6229011
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: May 8, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achyutharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Taurine and glycine derivatives
    Patent number: 4104285
    Abstract: Taurine and glycine derivatives of nor or bisnorcholanic acid or etiocholanic acid which are useful in increasing bile flow or decreasing lipid levels and their method of production from deoxycholic acid, including intermediates thereof.
    Type: Grant
    Filed: April 22, 1977
    Date of Patent: August 1, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hugo Gallo-Torres, Robert William Guthrie, James Guthrie Hamilton, Richard Wightman Kierstead, Ann Clare Sullivan
  • Hydroxycitric acid derivatives
    Patent number: 4028397
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: June 7, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 4007208
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: February 8, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 4006166
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: February 1, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 4005086
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: January 25, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 3994927
    Abstract: Ester and amide derivatives of three-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: November 30, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 3993668
    Abstract: Ester and amide derivatives of three-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: November 23, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 3993667
    Abstract: Ester and amide derivatives of three-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: November 23, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead