Patents by Inventor Robert William Scott
Robert William Scott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220354873Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.Type: ApplicationFiled: February 7, 2022Publication date: November 10, 2022Inventors: Steven Donald Axt, Pavel Robertovich Badalov, Katrien Brak, Silvio Campagna, Andrei Chtchemelinine, Edward Doerffler, Morin Mae Frick, Detian Gao, Lars V. Heumann, Brittanie Hoang, Willard Lew, Robert Ronald Milburn, Sean Timothy Neville, Bruce Ross, Erik Rueden, Robert William Scott, Dustin Siegel, Andrew C. Stevens, Clarissa Tadeus, Tiago Vieira, Andrew W. Waltman, Xianghong Wang, Mark Charles Whitcomb, Lydia Wolfe, Chia-Yun Yu
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Patent number: 11344565Abstract: Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl3-2LiCl, LaCl3, CeCl3, NdCl3, or YCl3; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.Type: GrantFiled: October 29, 2015Date of Patent: May 31, 2022Assignee: Gilead Sciences, Inc.Inventors: Steven Donald Axt, Pavel Robertovich Badalov, Katrien Brak, Silvio Campagna, Andrei Chtchemelinine, Edward Doerffler, Morin Mae Frick, Detian Gao, Lars V. Heumann, Brittanie Hoang, Willard Lew, Robert Ronald Milburn, Sean Timothy Neville, Bruce Ross, Erik Rueden, Robert William Scott, Dustin Siegel, Andrew C. Stevens, Clarissa Tadeus, Tiago Vieira, Andrew W. Waltman, Xianghong Wang, Mark Charles Whitcomb, Lydia Wolfe, Chia-Yun Yu
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Patent number: 11260422Abstract: A system of applying a coating to a vehicle in sequence with vehicle manufacture is disclosed. The vehicle may be inspected and/or logged into inventory. The vehicle may be electronically recorded into inventory using a computerized data acquisition and/or process control system. The vehicle may be prepared by an operator. The vehicle preparation may include applying masking materials to at least a portion of the vehicle. The vehicle preparation may include application of a pre-treatment to at least a portion of the vehicle. A coating may be applied to at least a portion of the vehicle. The coating may include one or more layers. The masking materials may be removed from the vehicle after the completion of the coating application. The vehicle may be electronically recorded into inventory using a data acquisition and/or process control system. The vehicle may be delivered and/or returned to the vehicle manufacturer.Type: GrantFiled: June 12, 2018Date of Patent: March 1, 2022Assignee: Ground Effects, Ltd.Inventors: Benjamin William Dollar, Michael Scott Boyko, Robert William Scott, Bradley John Pattison
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Publication number: 20200197422Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.Type: ApplicationFiled: November 22, 2019Publication date: June 25, 2020Inventors: Steven Donald Axt, Pavel Robertovich Badalov, Katrien Brak, Silvio Campagna, Andrei Chtchemelinine, Edward Doerffler, Morin Mae Frick, Detian Gao, Lars V. Heumann, Brittanie Hoang, Willard Lew, Robert Ronald Milburn, Sean Timothy Neville, Bruce Ross, Erik Rueden, Robert William Scott, Dustin Siegel, Andrew C. Stevens, Clarissa Tadeus, Tiago Vieira, Andrew W. Waltman, Xianghong Wang, Mark Charles Whitcomb, Lydia Wolfe, Chia-Yun Yu
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Publication number: 20180297059Abstract: A system of applying a coating to a vehicle in sequence with vehicle manufacture is disclosed. The vehicle may be inspected and/or logged into inventory. The vehicle may be electronically recorded into inventory using a computerized data acquisition and/or process control system. The vehicle may be prepared by an operator. The vehicle preparation may include applying masking materials to at least a portion of the vehicle. The vehicle preparation may include application of a pre-treatment to at least a portion of the vehicle. A coating may be applied to at least a portion of the vehicle. The coating may include one or more layers. The masking materials may be removed from the vehicle after the completion of the coating application. The vehicle may be electronically recorded into inventory using a data acquisition and/or process control system. The vehicle may be delivered and/or returned to the vehicle manufacturer.Type: ApplicationFiled: June 12, 2018Publication date: October 18, 2018Inventors: Benjamin William Dollar, Michael Scott Boyko, Robert William Scott, Bradley John Pattison
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Publication number: 20170361355Abstract: A system and method of applying a coating to a vehicle in sequence with vehicle manufacture is disclosed. The vehicle may be inspected and/or logged into inventory. The vehicle may be electronically recorded into inventory using a computerized data acquisition and/or process control system. The vehicle may be prepared by an operator. The vehicle preparation may include applying masking materials to at least a portion of the vehicle. The vehicle preparation may include application of a pre-treatment to at least a portion of the vehicle. A coating may be applied to at least a portion of the vehicle. The coating may include one or more layers. The masking materials may be removed from the vehicle after the completion of the coating application. The vehicle may be electronically recorded into inventory using a data acquisition and/or process control system. The vehicle may be delivered and/or returned to the vehicle manufacturer.Type: ApplicationFiled: June 15, 2017Publication date: December 21, 2017Inventors: BENJAMIN WILLIAM DOLLAR, MICHAEL SCOTT BOYKO, ROBERT WILLIAM SCOTT, BRADLEY JOHN PATTISON
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Publication number: 20170327488Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.Type: ApplicationFiled: May 26, 2017Publication date: November 16, 2017Inventors: Erik Mogalian, Robert William Scott, Bing Shi, Fang Wang
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Patent number: 9718807Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.Type: GrantFiled: August 4, 2016Date of Patent: August 1, 2017Assignee: GILEAD PHARMASSET LLCInventors: Robert William Scott, Justin Philip Vitale, Kenneth Stanley Matthews, Martin Gerald Teresk, Alexandra Formella, Jared Wayne Evans
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Patent number: 9682987Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.Type: GrantFiled: August 13, 2015Date of Patent: June 20, 2017Assignee: GILEAD PHARMASSET LLCInventors: Erik Mogalian, Robert William Scott, Bing Shi, Fang Wang
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Patent number: 9676804Abstract: Methods for isolating 9-{(R)-2-[((S)—{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine (compound 16): a method for preparing in high diastereomeric purity, intermediate compounds 13 and 15: and a method for preparing intermediate compound 12: 9-{(R)-2-[((S)—{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine has anti-viral properties.Type: GrantFiled: April 21, 2016Date of Patent: June 13, 2017Assignee: GILEAD SCIENCES, INC.Inventors: Denise A. Colby, Andrew Anthony Martins, Benjamin James Roberts, Robert William Scott, Nicole S. White
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Publication number: 20160340345Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.Type: ApplicationFiled: August 4, 2016Publication date: November 24, 2016Inventors: Robert William Scott, Justin Philip Vitale, Kenneth Stanley Matthews, Martin Gerald Teresk, Alexandra Formella, Jared Wayne Evans
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Publication number: 20160311840Abstract: Methods for isolating 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine (compound 16): a method for preparing in high diastereomeric purity, intermediate compounds 13 and 15: and a method for preparing intermediate compound 12: 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine has anti-viral properties.Type: ApplicationFiled: April 21, 2016Publication date: October 27, 2016Inventors: Denise A. COLBY, Andrew Anthony MARTINS, Benjamin James ROBERTS, Robert William SCOTT, Nicole S. WHITE
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Patent number: 9346841Abstract: Methods for isolating 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine (compound 16): a method for preparing, in high diastereomeric purity, intermediate compounds 13 and 15: and a method for preparing intermediate compound 12: 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine has anti-viral properties.Type: GrantFiled: April 8, 2015Date of Patent: May 24, 2016Assignee: Gilead Sciences, Inc.Inventors: Denise A. Colby, Andrew Anthony Martins, Benjamin James Roberts, Robert William Scott, Nicole S. White
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Publication number: 20160122356Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.Type: ApplicationFiled: October 29, 2015Publication date: May 5, 2016Inventors: Steven Donald Axt, Pavel Robertovich Badalov, Katrien Brak, Silvio Campagna, Andrei Chtchemelinine, Edward Doerffler, Morin Mae Frick, Detian Gao, Lars V. Heumann, Brittanie Hoang, Willard Lew, Robert Ronald Milburn, Sean Timothy Neville, Bruce Ross, Erik Rueden, Robert William Scott, Dustin Siegel, Andrew C. Stevens, Clarissa Tadeus, Tiago Vieira, Andrew W. Waltman, Xianghong Wang, Mark Charles Whitcomb, Lydia Wolfe, Chia-Yun Yu
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Publication number: 20150344488Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5 -(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro [2 .4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.Type: ApplicationFiled: August 13, 2015Publication date: December 3, 2015Inventors: Erik Mogalian, Robert William Scott, Bing Shi, Fang Wang
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Publication number: 20150291638Abstract: Methods for isolating 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine (compound 16): a method for preparing, in high diastereomeric purity, intermediate compounds 13 and 15: and a method for preparing intermediate compound 12: 9-{(R)-2-[((S)-{[(S)-1-(isopropoxycarbonyl)ethyl]amino}phenoxyphosphinyl)methoxy]propyl}adenine has anti-viral properties.Type: ApplicationFiled: April 8, 2015Publication date: October 15, 2015Inventors: Denise A. Colby, Andrew Anthony Martins, Benjamin James Roberts, Robert William Scott, Nicole S. White
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Patent number: 9139570Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.Type: GrantFiled: January 20, 2015Date of Patent: September 22, 2015Assignee: GILEAD PHARMASSET LLCInventors: Erik Mogalian, Robert William Scott, Bing Shi, Fang Wang
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Publication number: 20150232453Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.Type: ApplicationFiled: May 5, 2015Publication date: August 20, 2015Inventors: Robert William Scott, Justin Philip Vitale, Kenneth Stanley Matthews, Martin Gerald Teresk, Alexandra Formella, Jared Wayne Evans
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Patent number: 9056860Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.Type: GrantFiled: March 13, 2013Date of Patent: June 16, 2015Assignee: Gilead Pharmasset LLCInventors: Robert William Scott, Justin Philip Vitale, Kenneth Stanley Matthews, Martin Gerald Teresk, Alexandra Formella, Jared Wayne Evans
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Patent number: D804089Type: GrantFiled: September 12, 2016Date of Patent: November 28, 2017Assignee: Ground Effects, Ltd.Inventors: Benjamin William Dollar, Michael Scott Boyko, Robert William Scott, Bradley John Pattison