Patent number: 6395759
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, where G is a methylene or ethylene linkage; R1 is hydrogen, C1-6alkylO—; R2 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, CF3, CF3O—, CF3S—, CF3CO—, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO—, C1-6alkylCO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4-alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl and substituted benzoyl, phenyl-C1-4alkyl-, C1-6alkylSO2—, (C1-4alkyl)2NSO2— or (C1-4alkyl)NHSO2—; R3 is hydrogen, halogen, CN, N3, trifluoromethyldiazirinyl, C1-6alkylO—, C1-6alkylS—, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl, CF3CO—, C1-6alkylCO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, or —NR5R6 where R5 is hydrogen or C1-4alkyl; and R6 is hydrogen, C1-4alkyl, —CHO, —CO2C1-4alkyl or —COC1-4alk
Type:
Grant
Filed:
June 1, 1999
Date of Patent:
May 28, 2002
Assignee:
SmithKline Beecham p.l.c.
Inventors:
Mervyn Thompson, Antonio Kuok Keong Vong, Robert William Ward
Patent number: 6245778
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof:
where
R1 is hydrogen, C1-6 alkyl optionally substituted by hydroxy or C1-4alkoxy, or C1-6 alkylphenyl;
R2 is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, C1-6 alkylO-, C1-6 alkylS-, C1-6 alkyl, C3-6cycloalkyl,
C3-6cycloalkyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl, CF3, CF3O, CF3CO—, C1-6alkylCO-, C3-6cycloalkylCO-,
C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-,
or —NR3R4 where
R3 is hydrogen or C1-4 alkyl, and
R4 is hydrogen, C1-4alkyl, —CHO,
—CO2C1-4alkyl or —COC1-4alkyl;
or two R2 groups form a saturated carbocyclic ring optionally interrupted by oxygen;
and X is selected from hydrogen, halogen, cyano, alkyl and alkoxy;
are useful in the treatment and prophylaxis of inter alia epilepsy.
Type:
Grant
Filed:
November 23, 1999
Date of Patent:
June 12, 2001
Assignee:
SmithKline Beecham p.l.c.
Inventors:
Michael Stewart Hadley, John David Harling, Frank Peter Harrington, Mervyn Thompson, Robert William Ward