Abstract: An apparatus for testing cardiac devices comprises an inflow and an outflow chamber, a mount for supporting a prosthetic valve, and a fluid driving device operable to vary a pressure differential of a fluid between the inflow chamber and the outflow chamber in repeating cycles. The apparatus can comprise a bypass valve to modulate pressure characteristics across the prosthetic valve, reservoirs to maintain a pressure inside the apparatus, and compliance elements to modulate pressure characteristics in the apparatus. Methods for operating the apparatus include controlling the bypass valve to control testing characteristics across the prosthetic device, and methods for monitoring the pressure inside of the apparatus.

Abstract: The present disclosure concerns radiopharmaceutical compositions of radioactive halogenated benzylguanidine (such as radioiodinated MIBG) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. In a preferred embodiment, the composition has at least 97% of radiochemical purity for at least 4 days. Advantageously, the compositions of the present disclosure may be devoid of parabens, which are carcinogenic and yet are used in known radioactive MIBG compositions. The present disclosure also provides processes of preparing a radioactive halogenated benzylguanidine composition. The compositions of the present disclosure can be used in diagnosis and treatment of various diseases.

Abstract: Techniques for providing multi-user multi-touch projected capacitive touch sensors are disclosed herein. Some embodiments may include a method that includes receiving a first sense signal from a first sensing array, the first sensing array configured to provide the first sense signal indicating a first touch on a first touch surface of a touch substrate as well as receiving a second sense signal from a second sensing array, the second sensing array configured to provide the second sense signal indicating a second touch on a second touch surface of a second touch substrate occurring concurrently to the first touch. The method may further include determining whether the first touch and the second touch share at least one anti-ghost. The method may also include associating the first touch and the second touch with a common touch entity in response to determining that the first touch and the second touch share the at least one anti-ghost.

Abstract: Disclosed is a refiner filling piece for a refiner having a rotor that rotates about an axis of rotation and cooperates with a stator to mechanically treat a pulp containing cellulosic fibers. The refiner filling piece is mountable to the rotor or the stator. The refiner filling piece comprises a base and a plurality of spaced-apart refiner bars, each refiner bar having a leading surface and a trailing surface. At least one of the refiner bars has a leading surface coated with a first coating and a trailing surface coating with a second coating. The first and second coatings have different chemical compositions and/or different physical properties. Alternatively, the first and second coatings may be applied to distinct portions of the same surface.

Abstract: A method of reducing the bandwidth usage of a network comprises intercepting traffic between a TCP server and a TCP client using TCP protocols that use client acknowledgements; identifying client acknowledgements from the TCP protocols; identifying the sequence number of a last received client acknowledgements from the intercepted traffic; identifying the sequence number of a last sent client acknowledgement from the intercepted traffic; calculating an unacknowledged byte value based on the difference between the last received client acknowledgement sequence number and the last sent client acknowledgement sequence number; comparing the calculated unacknowledged byte value with a predetermined threshold value, to determine whether the calculated unacknowledged byte value is at least as great as the predetermined threshold value; and transmitting the identified client acknowledgements into the network when the compared unacknowledged byte value is at least as great as the predetermined threshold value.

Abstract: The present technology relates to an automatically locking, releasable, safety knob assembly for a stove. The assembly includes a base with a locking notch. An adapter mates with the stove's valve stem and has a head, a tubular middle section, and an adapter base with a central aperture for receiving the valve stem. The knob includes a housing with a housing disk covering the base, an arm movement channel aligned with the locking notch in the locked configuration, and a central aperture for receiving the adapter head. The assembly further includes a sub-assembly with a slidable button allowing free rotation of the knob in the unlocked configuration, an automatic locking arm biased with the slidable button, and engagement of the button causing the arm to disengage from the locking notch and move in the arm movement channel, enabling the knob to freely rotate and rotate the valve stem.

Abstract: A method is performed at a server system associated with a media streaming service. The method includes providing, a first client device, playback of a first media content item; and receiving, from the first client device, a second media content item to be associated with the first media content item. The method includes, after receiving the second media content item from the first client device: providing, a second client device, a user interface that includes graphical representations of a plurality of media content items that have been uploaded by other users of the media streaming service as related to the first media content item; receiving, from the second client device, a user selection of a graphical representation of the second media content item; and in response, providing the second media content item concurrently with playback of the first media content item.

Abstract: A modular, cooling device for providing cool air to a body and/or an external environment comprises a first body portion combining a cooling medium and air passageways therethrough. The first body portion may be detached from second and third body portions and placed in a freezer to refreeze the cooling media, and reattached for further use. The second body portion may include a material that absorbs condensate that forms within the air passageways. The third body portion may include a fan for driving air into the cooling device, through the air passageways and out of the cooling device. When passing through the air passageways, a heat transfer is produced between the passing air and the cooling medium, cooling the passing air. The fan speed may be varied to adjust air flow.

Abstract: Methods and devices are provided for allowing a mobile device (e.g., a key fob or a consumer electronic device, such as a mobile phone, watch, or other wearable device) to interact with a vehicle such that a location of the mobile device can be determined by the vehicle, thereby enabling certain functionality of the vehicle. A device may include both RF antenna(s) and magnetic antenna(s) for determining a location of a mobile device relative to the vehicle. Such a hybrid approach can provide various advantages. Existing magnetic coils on a mobile device (e.g., for charging or communication) may be re-used for distance measurements that are supplemented by the RF measurements. Any device antenna may provide measurements to a machine learning model that determines a region in which the mobile device resides, based on training measurements in the regions.

Abstract: Amisulpride is used in the therapy of nausea, vomiting or retches. The therapy may utilize a novel injectable formulation, in unit dosage form, comprising less than 50 mg amisulpride.

Abstract: Biodegradable chelating agents comprising tropolone, a derivate of tropolone, as well as combinations and salts thereof may be incorporated into a variety of fabric care compositions and delivery formats. The fabric care compositions may include at least one component, according to Formula 7, as well as combinations and salts thereof: in which: R1 is hydroxyl, C1-C6 carboxyl, a linear or branched C1-C6 alkyl; a linear or branched C2-C6 alkenyl; or a linear or branched C2-C6 alkynyl group; a is from 0 to 5; R2 is a fused C1-C6 cycloalkyl, a fused C1-C6 cycloalkoxy, or a fused C1-C6 cycloalkenyl; b is from 0 to 4; R3 is oxygen or hydroxyl; and c is from 0 to 4.

Abstract: Biodegradable chelating agents may be incorporated into a variety of fabric care compositions and delivery formats. The fabric care compositions may include at least one component, according to Formula 7, as well as combinations and salts thereof: in which: R1 is hydroxyl, C1-C6 carboxyl, a linear or branched C1-C6 alkyl; a linear or branched C2-C6 alkenyl; or a linear or branched C2-C6 alkynyl group; a is from 0 to 5; R2 is a fused C1-C6 cycloalkyl, a fused C1-C6 cycloalkoxy, or a fused C1-C6 cycloalkenyl; b is from 0 to 4; R3 is oxygen or hydroxyl; and c is from 0 to 4.

Abstract: An apparatus for delivering an active ingredient into the skin of an animal at a defined depth, the apparatus including: a microprojection array including a plurality of microprojections having a density of at least 2,000 projections per cm2; and an applicator that drives the microprojection array towards the skin in use so that the microprojection array impacts on the skin with a mass-to-velocity ratio of between 0.0005 g/m/s and 0.1 g/m/s per cm2.

Abstract: The present invention pertains to a child resistant cap configured to seal a container while keeping the contents secure therein. The child resistant cap disclosed herein is intended to allow access to those instructed on the manner of removal to allow the dispensing of a container's contents while providing suitable resistance to the efforts of children to gain access. The manner of removal requires multiple steps intended to resist the efforts of children in accordance with current poison prevention packaging regulations.

Abstract: A system for determining insurance parameters, the system comprising: one or more monitoring devices configured to monitor parameters of members of an animal population; a data repository comprising two or more records, each (i) being associated with a respective member of the members, and (ii) including one or more monitored parameters of the respective member as monitored by at least one of the monitoring devices over time; and a processing circuitry configured to: obtain at least a subset of the records, the subset being associated with a group of given members of the members; determine one or more GHGE affecting parameters based on the subset; estimate an amount of GHGE in an environment housing the animal population utilizing the GHGE affecting parameters; and determine one or more insurance parameters, for insuring at least one animal of the animal population, based on the estimated amount.

Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.

Abstract: An apparatus is provided for forming a cigarette filter rod member defining a longitudinal axis. A rod-forming unit is configured to form a continuous supply of a filter material into a continuous cylindrical rod member. An insertion unit configured to insert a carrier carrying a plurality of frangible microcapsule objects into the rod member. Associated apparatuses and methods are also provided.

Abstract: The present invention relates to methods, uses, and compositions for the treatment of cancer (e.g., a lung cancer; a cervical cancer; a breast cancer; a head and neck cancer; a liver cancer; a bladder cancer; a gastric cancer; an esophageal cancer; a pancreatic cancer; a kidney or renal cancer; a melanoma; an ovarian cancer; or a colorectal cancer). More specifically, the invention concerns the treatment of patients having cancer with an anti-TIGIT antagonist antibody, including treatment with an anti-TIGIT antagonist antibody in a combination therapy.

Abstract: A method comprises receiving at least one of a transcript, a video recording, an audio recording, or an audiovisual recording of at least a portion of an interaction, and receiving an audiovisual score for a relevant portion of the interaction, the received audiovisual score being based on data received from at least a subset of participants in the interaction. A reaction metric is calculated based on the received audiovisual score. The at least one transcript, video recording, audio recording, or audiovisual recording is then displayed proximate to the reaction metric.

Abstract: Antibody-drug conjugates (ADCs) comprising an antibody construct that binds specifically binds human folate receptor alpha (FR?) (an anti-FR? antibody construct) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.