Abstract: Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

Abstract: Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

Abstract: Provided herein is a method for the large-scale manufacture of liposomal drug formulations containing an aminoglycoside such as amikacin having advantageous lipid/drag characteristics. The method utilizes a particular relative flow rate ratio of lipid to drug streams to obtain liposomes with a high aminoglycoside encapsulation efficiency. The resulting liposomal drug formulations advantageously comprise an overall lipid-to-drug weight ratio of less than 1:1.

Abstract: Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

Abstract: A fly-by-wire system for a rotorcraft includes a computing device having control laws. The control laws are operable to engage a level-and-climb command in response to a switch of a pilot control assembly being selected. The level-and-climb command establishes a roll-neutral (“wings level”) attitude with the rotorcraft increasing altitude. The switch may be disposed on a collective control of the pilot control assembly (e.g., a button on a grip of the collective control). Selection of the switch may correspond to a button depress. The level-and-climb command may include a roll command and a collective pitch command. One or more control laws may be further operable to increase or decrease forward airspeed in response to pilot engagement of the level-and-climb command. The level-and-climb command may correspond to a go-around maneuver, an abort maneuver, or an extreme-attitude-recovery maneuver to be performed by the rotorcraft.

Abstract: A fly-by-wire system for a rotorcraft includes a computing device having control laws. The control laws are operable to engage a level-and-climb command in response to a switch of a pilot control assembly being selected. The level-and-climb command establishes a roll-neutral (“wings level”) attitude with the rotorcraft increasing altitude. The switch may be disposed on a collective control of the pilot control assembly (e.g., a button on a grip of the collective control). Selection of the switch may correspond to a button depress. The level-and-climb command may include a roll command and a collective pitch command. One or more control laws may be further operable to increase or decrease forward airspeed in response to pilot engagement of the level-and-climb command. The level-and-climb command may correspond to a go-around maneuver, an abort maneuver, or an extreme-attitude-recovery maneuver to be performed by the rotorcraft.

Abstract: A flight control system having a control law, the control law operable to generate a modified pitch command, the modified pitch command representing a greater amount of collective pitch compared to an amount of collective pitch generated by a first pitch command, the modified pitch command being generated because a vertical descent speed of the rotorcraft at a given forward airspeed is greater than a threshold. A method of avoiding entry into an undesired vertical descent speed region during operation of a rotorcraft, including measuring a forward airspeed; evaluating a vertical descent of the rotorcraft; and generating a modified collective pitch command in respond to a first collective pitch command having a collective pitch value that would cause the rotorcraft to experience a vertical descent rate greater than a threshold value at the forward airspeed of the rotorcraft.

Abstract: A flight control system having a control law, the control law operable to generate a modified pitch command, the modified pitch command representing a greater amount of collective pitch compared to an amount of collective pitch generated by a first pitch command, the modified pitch command being generated because a vertical descent speed of the rotorcraft at a given forward airspeed is greater than a threshold. A method of avoiding entry into an undesired vertical descent speed region during operation of a rotorcraft, including measuring a forward airspeed; evaluating a vertical descent of the rotorcraft; and generating a modified collective pitch command in respond to a first collective pitch command having a collective pitch value that would cause the rotorcraft to experience a vertical descent rate greater than a threshold value at the forward airspeed of the rotorcraft.

Abstract: According to one embodiment, a landing point indication system includes an image provider, a rotorcraft position provider, a pilot image generation system, and a display device. The image provider is operable to provide a visual representation of an area underneath a rotorcraft. The rotorcraft position provider is operable to provide information indicating a position of the rotorcraft. The pilot image generation system is operable to generate a supplemented visual representation. The supplemented visual representation includes the visual representation of the area underneath the aircraft and information indicating a position of the rotorcraft relative to the visual representation. The display device is operable to display the supplemented visual representation within the rotorcraft.

Abstract: An apparatus and method for electrostatic spray deposition of small targets, such as medical devices, like stents. The apparatus includes a target holder that applies a first electrical potential to the target, and an electrostatic dispensing nozzle that applies a second potential sufficient to attract the coating fluid from the nozzle toward the target. Because the entire dispensing nozzle is conductive, the coating fluid may receive a greater charge than may be obtained with internal electrode-type nozzles. Electrostatic attraction of the coating fluid to the target is enhanced by the combination of higher charge density imparted to the coating fluid by the conductive nozzle, and application of a momentary voltage spike to the target to provide consistent conductivity between the target and its holder, thereby ensuring the target is presented with the full first potential applied to the holder. The voltage spike may also be used independently of the conductive nozzle.

Abstract: An apparatus and method for electrostatic spray deposition of small targets, such as medical devices like stents. The apparatus includes a target holder which applies a first electrical potential to the target, and an electrostatic dispensing nozzle which applies a second potential sufficient to attract the coating fluid from the nozzle toward the target. Because the entire dispensing nozzle is conductive, the coating fluid may receive a greater charge than may be obtained with internal electrode-type nozzles. Electrostatic attraction of the coating fluid to the target is enhanced by the combination of higher charge density imparted to the coating fluid by the conductive nozzle, and application of a momentary voltage spike to the target to provide consistent conductivity between the target and its holder, thereby ensuring the target is presents the full first potential applied to the holder. The voltage spike may also be used independently of the conductive nozzle.

Abstract: An apparatus and method for electrostatic spray deposition of small targets, such as medical devices like stents. The apparatus includes a target holder which applies a first electrical potential to the target, and an electrostatic dispensing nozzle which applies a second potential sufficient to attract the coating fluid from the nozzle toward the target. Because the entire dispensing nozzle is conductive, the coating fluid may receive a greater charge than may be obtained with internal electrode-type nozzles. Electrostatic attraction of the coating fluid to the target is enhanced by the combination of higher charge density imparted to the coating fluid by the conductive nozzle, and application of a momentary voltage spike to the target to provide consistent conductivity between the target and its holder, thereby ensuring the target is presents the full first potential applied to the holder. The voltage spike may also be used independently of the conductive nozzle.

Abstract: An apparatus and method for electrostatic spray deposition of small targets, such as medical devices like stents. The apparatus includes a target holder which applies a first electrical potential to the target, and an electrostatic dispensing nozzle which applies a second potential sufficient to attract the coating fluid from the nozzle toward the target. Because the entire dispensing nozzle is conductive, the coating fluid may receive a greater charge than may be obtained with internal electrode-type nozzles. Electrostatic attraction of the coating fluid to the target is enhanced by the combination of higher charge density imparted to the coating fluid by the conductive nozzle, and application of a momentary voltage spike to the target to provide consistent conductivity between the target and its holder, thereby ensuring the target is presents the full first potential applied to the holder. The voltage spike may also be used independently of the conductive nozzle.

Abstract: An infra-red responsive fingerprint composition and method for manufacturing by sifting and mixing a minor proportion of finely divided carbon black (50 to 75 millimicrons) and a major proportion of infra-red responsive finely divided pigments containing milori blue (250 to 400 mesh), manganese dioxide (300 to 400 mesh), aluminum powder (1 to 75 microns) and mica (10 to 20 microns). A small amount of gum arabic as binder is included to facilitate adhesion of the print powder to latent prints. On white surfaces the fingerprint powder is black. On dark surfaces the fingerprint powder is brightly reflective so that when lifted or transferred to a white backing the color changes from brightly reflective to black. The reflective color becomes even more vivid under infra-red. Storage is preferably in tightly sealed containers in the presence of dessicant capsules to prevent moisture pick-up and caking of the gum arabic.