Patents by Inventor Robert Yongxin Zhao

Robert Yongxin Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040001838
    Abstract: Cytotoxic agents bearing a polyethylene glycol (PEG) linking group having a terminal active ester, cytotoxic conjugates comprising one or more cytotoxic agents linked to a cell-binding agent via PEG linking groups, and methods for producing both are disclosed. A therapeutic composition comprising a therapeutically-effective amount of one of the cytotoxic conjugates of the present invention, and a method of killing selected cell populations comprising contacting target cells, or tissue containing target cells, with an effective amount of one of the cytotoxic conjugates, are also disclosed.
    Type: Application
    Filed: December 21, 2001
    Publication date: January 1, 2004
    Applicant: ImmunoGen, Inc.
    Inventors: Robert Yongxin Zhao, Michael Louis Miller, Wayne Charles Widdison, Ravi V.J. Chari
  • Publication number: 20030199519
    Abstract: Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the prodrug, and in which the prodrug also has a moiety, such as a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described; such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytoxic drugs in a targeted fashion.
    Type: Application
    Filed: April 5, 2002
    Publication date: October 23, 2003
    Applicant: IMMUNOGEN INC.
    Inventors: Robert Yongxin Zhao, Ravi V.J. Chari
  • Publication number: 20030195365
    Abstract: Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): 1
    Type: Application
    Filed: October 7, 2002
    Publication date: October 16, 2003
    Applicant: IMMUNOGEN INC.
    Inventors: Robert Yongxin Zhao, Ravi V.J. Chari
  • Patent number: 6586618
    Abstract: Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): and improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: July 1, 2003
    Assignee: Immunogen Inc.
    Inventors: Robert Yongxin Zhao, Ravi V. J. Chari