Abstract: Provided are TYK2 inhibitors of Formula I, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. These compounds are useful, for example, in treating TYK2-mediated disorders, such as, autoimmune and inflammatory disorders, metabolic disorders, proliferative disorders, endocrine disorders, neurological disorders, allergic disorders, and disorders associated with transplantation.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: A system is provided for detecting and remediating computing system breaches using computing network traffic monitoring. In particular, the system may identify one or more technology elements within a network as well as relationships between computing systems associated with said elements to determine a network topology. Based on the network topology, the system may use historical network traffic data associated with the technology elements in the network to generate predicted entry points and lateral pathways of a security breach that may take place within particular computing systems. Then, based on the technology elements affected as well as entry points and path traversals of the breach, the system may generate and/or implement one or more remediation steps to address existing and/or future breaches. In this way, the system may provide an intelligent method of augmenting the security of a computing network.

Abstract: A system is provided for monitoring real-time data inputs across multiple channels, determining potential impacts to a network or entity policy taxonomy, and taking one or more automated, responsive actions based on determined impacts. In this way, the system described herein is able to optimize system processes and system protections on an enterprise-wide scale in response to current events, policy or regulation changes, or predicted measures taken by private or public entities that may necessitate adaptation of one or more workflow processes or technology taxonomies, either upstream or downstream of the system itself.

Abstract: A system for generating an identity-based Non-Fungible Token (NFT) that uses, as a least a portion of the input file, a verified identity of the user. Once generated, the identity-based NFT is stored within a distributed trust computing network, which provides for verifying the authenticity and unalerted state of the NFT. Subsequently, the identity-based NFT can be accessed via the distributed trust computing network to verify the identity of the user. Additionally, the NFT may use other verified data as a portion of the input file, such as verified identity of users having a familial relationship with the user, verified life events, and/or verified user preferences. Further, the NFT may include one or more markers that identify a familial relationship and are configured to link the NFT to other NFTs associated with the related users.

Abstract: Systems, computer program products, and methods are described herein for tracking resources using non-fungible tokens. The present invention is configured to receive a request for a non-fungible token (NFT) for a resource, wherein the resource is a physical object; initiate a non-fungible token (NFT) generator on the resource; generate a unique digital signature for the resource by generating a scanned image of the resource and identifying one or more features of the resource from the image; generate an NFT comprising a unique digital signature for the resource; determine a physical condition of the resource; store the physical condition of the resource in a first metadata layer associated with the NFT; and record the NFT for the resource on a distributed ledger.

Abstract: A fluid exchanger may exchange a fluid (e.g., coolant) in a reservoir (e.g., vehicle radiator) by removing or withdrawing a first fluid (e.g., old, spent, used, etc.) and by introducing a second fluid (e.g., new, clean, etc.). In some examples, the exchanger includes a valve construction that permits easy and safe transitioning from a first mode in which the fluid in the vehicle is run in a loop (e.g., after a cleaner is introduced) to a second mode in which the fluid is exchanged. In some examples, the exchanger includes a restrictor that stops fluid from flowing when the pressure fails to satisfy a threshold (e.g., where the pressure is below a threshold). In some examples, the exchanger includes a safety valve (e.g., ball valve) in the bottom of the new fluid tank, such that when the tank is empty, the valve will close and reduce the likelihood of unintentionally pushing air into the system (e.g., emptying the reservoir).

Abstract: A system for communicating email messages using tokens receives a request to send an email message to a receiver. The email message is associated with a sender's email address. The system determines whether the sender's email address is associated with a token from a plurality of tokens stored in a token-email address mapping table. The system generates a particular token for the sender's email address in response to determining that the sender's email address is not associated with a token, where the particular token uniquely identifies the sender's email address. The system sends the email message using the particular token instead of the sender's email address, such that the sender's email address remains anonymous from the perspective of the receiver.

Abstract: A device is configured to receive an interaction request from the first user that identifies an address for a contract that is stored in a blockchain and to access machine-executable instructions associated with the contract. The device is further configured to determine a projected number of virtual resources and real-world resources for the first user based on a number of available resources for the first user and the machine-executable instructions for transferring resources between the first user and the second user in the contract. The device is further configured to output the projected number of virtual resources to the first user and to output the projected number of real-world resources to the first user. The device is further configured to initiate a transfer of resources between the first user and the second user.

Abstract: Systems, computer program products, and methods are described herein for assessing cyber-based data protection exposure using artificial intelligence. The method includes compiling an assessment of cyber-based data exposure of an entity using artificial intelligence, said entity comprised of a set of cyber-based data, an internal set of cyber-based protective measures, and an external set of cyber-based protective measures. The method further includes comparing the assessment of cyber-based data exposure against an open-source database. The method further includes generating an analysis of cyber-based data protection exposure associated with the entity based on the comparison of the assessment of cyber-based data exposure against the open-source database. The analysis of cyber-based data protection exposure associated with the entity comprises an estimation of exposure of the set of cyber-based data.

Abstract: A dental tool tip is removably attached to a vibratory dental handpiece. The dental tool tip includes a mounting base configured for removable engagement with the dental handpiece, the mounting base having an open-ended, internal bore extending therethrough and configured for fluid communication with the dental handpiece and a body having a free distal, terminal end and at least a portion of the body having an abrasive coating. A mounting rod proximally extends from the body and is at least partially received within the internal bore. The mounting rod has at least one open-ended passage extending therethrough and in registry and fluid communication with the internal bore, thereby being configured to enable at least one of air or water to advance from the dental handpiece, and flow out onto the body, via the internal bore and the at least one channel.

Abstract: Described herein are compositions and methods for identifying, selecting, or culturing cells comprising a subject nucleic acid sequence of interest. Generally, a nucleic acid comprising a subject nucleic acid and a sequence encoding an enzyme molecule involved in biosynthesis of an amino acid is introduced into a cell. The cell is then grown on media lacking the amino acid, such that cells comprising the introduced nucleic acid are capable of growth. In some instances, the cell further comprises an inhibitor of the enzyme molecule to increase the stringency of the selection.

Abstract: A device is configured to receive a user input from a user device indicating a first gesture performed by a user in a real-world environment and to identify a first token within a gesture map corresponding with the first gesture. The device is further configured to identify a second gesture performed by an avatar within a virtual environment that is associated with the user and to identify a second token within the gesture map corresponding with the second gesture. The device is further configured to combine the first token and the second token to generate an authentication token and to verify an identity of the user based on the authentication token.

Abstract: A system for real-time authenticated obfuscation of electronic data provides real-time visual obfuscation of the data by transforming displayed data into undecipherable data when viewed by an unauthorized user while maintaining access for an authorized user. The system may further provide application-level obfuscation of electronic data via cryptographic keys such that only authorized applications may decrypt the encrypted data. In this way, the system provides secure access control of electronic data within a networked environment.

Abstract: Systems, computer program products, and methods are described herein for deployable software vulnerability testing platform. The present invention is configured to receive, from a user input device, an initial request from a user to generate a deployable software vulnerability testing (SVT) engine; prompt an SVT dashboard for display on the user input device to receive one or more input parameters associated with the first vulnerability in response to receiving the initial request; receive, via the SVT dashboard, the one or more input parameters; generate the SVT engine based on at least the one or more input parameters; receive, from the user input device, one or more deployment parameters associated with a deployment of the SVT engine; and deploy the SVT engine within the distributed technology infrastructure to identify the one or more instances of the first vulnerability based on at least the one or more deployment parameters.

Abstract: Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure-stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.