Patents by Inventor Robert Yuan
Robert Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10273536Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.Type: GrantFiled: March 10, 2016Date of Patent: April 30, 2019Assignees: GENIA TECHNOLOGIES, INC., ROCHE MOLECULAR SYSTEMS, INC.Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech, Hui Tian, Robert Yuan, John Foster, Roger Chen
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Publication number: 20160327507Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.Type: ApplicationFiled: March 10, 2016Publication date: November 10, 2016Inventors: Randall W. DAVIS, Edward Shian LIU, Eric Takeshi HARADA, Anne AGUIRRE, Andrew TRANS, James POLLARD, Cynthia CECH, Hui TIAN, Robert YUAN, John FOSTER, Roger CHEN
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Patent number: 9322062Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.Type: GrantFiled: October 22, 2014Date of Patent: April 26, 2016Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech, Hui Tian, Robert Yuan, John Foster, Roger Chen
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Patent number: 8303895Abstract: An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.Type: GrantFiled: November 25, 2008Date of Patent: November 6, 2012Assignee: CapheidInventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
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Patent number: 8029733Abstract: A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.Type: GrantFiled: October 30, 2007Date of Patent: October 4, 2011Assignee: CepheidInventors: Ronald Chang, Lee A. Christel, Gregory T. A. Kovacs, William A. McMillan, M. Allen Northrup, Kurt E. Petersen, Farzad Pourahmadi, Steven J. Young, Robert Yuan, Douglas B. Dority
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Publication number: 20110176971Abstract: An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.Type: ApplicationFiled: November 25, 2008Publication date: July 21, 2011Applicant: CepheidInventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
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Patent number: 7499022Abstract: A device for providing user input to a computer includes a base member with a tracking sensor for detecting motion of the base member and a vertical grip member that extends upward from the base member. A scroll wheel is rotatably mounted in the grip member and oriented so as to be rotatable by a substantially arc-like movement of a thumb of a hand holding the grip member.Type: GrantFiled: November 5, 2004Date of Patent: March 3, 2009Assignee: FastMoto, LLCInventors: Jeff Ma, Ain McKendrick, Robert Yuan
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Patent number: 7462323Abstract: An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.Type: GrantFiled: November 21, 2003Date of Patent: December 9, 2008Assignee: CepheidInventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
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Publication number: 20080286151Abstract: An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.Type: ApplicationFiled: November 21, 2003Publication date: November 20, 2008Applicant: CepheidInventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
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Publication number: 20080254532Abstract: A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.Type: ApplicationFiled: October 30, 2007Publication date: October 16, 2008Applicant: CepheidInventors: Ronald Chang, Lee A. Christel, Gregory T.A. Kovacs, William A. McMillan, M. Allen Northrup, Kurt E. Petersen, Farzad Pourahmadi, Steven J. Young, Robert Yuan, Douglas B. Dority
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Patent number: 7255833Abstract: This invention provides an apparatus for rapidly heating and/or cooling a sample in a reaction vessel. In some embodiments, the apparatus includes optics for the efficient detection of a reaction product in the vessel. The invention also provides a reaction vessel having a reaction chamber designed for optimal thermal conductance and for efficient optical viewing of reaction products in the chamber.Type: GrantFiled: March 3, 2003Date of Patent: August 14, 2007Assignee: CepheidInventors: Ronald Chang, Lee A. Christel, Gregory T. A. Kovacs, William A. McMillan, M. Allen Northrup, Kurt E. Petersen, Farzad Pourahmadi, Steven J. Young, Robert Yuan, Douglas B. Dority
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Patent number: 6988308Abstract: Hard biasing of a magnetoresistive sensor or a spin valve sensor in a magnetic read head is initialized by repeatedly applying a magnetic field to the hard biasing at any level of fabrication of the magnetic read head or any combination of levels of fabrication of the read head such as at the wafer level, row bar level, single slider level, head gimbal assembly (HGA) level and/or head stack assembly (HSA) level.Type: GrantFiled: January 18, 2002Date of Patent: January 24, 2006Assignee: International Business Machines CorporationInventors: Christopher William Bergevin, Carol Inouye Chiu, Robert Yuan-Shih Li, Albert Shou-Chi Su
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Publication number: 20050156889Abstract: A device for providing user input to a computer includes a base member with a tracking sensor. A vertically oriented pistol grip member is disposed at an aft portion of the base member and extends upward therefrom. A pistol barrel member extends forward from an upper portion of the pistol grip member. The counterweight is disposed toward the aft portion of the base member so as to counterbalance a weight of the pistol barrel member and a weight of the pistol grip member. The counterweight can also provide a stabilizing force when the user holds and operates the pistol grip member.Type: ApplicationFiled: November 5, 2004Publication date: July 21, 2005Applicant: MonsterGecko, LLCInventors: Jeff Ma, Ain McKendrick, Robert Yuan
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Publication number: 20050148389Abstract: A device for providing user input to a computer includes a base member that has a base axis. A tracking sensor for sensing motion of the base member is mounted in the base member at a sensor location along the base axis. A vertical grip member extends upward from the base member. A major axis of the vertical grip member intersects the base axis at a grip axis location that is offset from the sensor location by a distance greater than zero.Type: ApplicationFiled: November 5, 2004Publication date: July 7, 2005Applicant: MonsterGecko, LLCInventors: Jeff Ma, Ain McKendrick, Robert Yuan
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Publication number: 20050116926Abstract: A device for providing user input to a computer includes a vertical grip member that has a trigger disposed on a forward surface thereof so that the trigger is operable by a first finger of a hand holding the grip member. A first single throw electrical switch coupled to the trigger generates signals in response to depression of the trigger.Type: ApplicationFiled: November 5, 2004Publication date: June 2, 2005Applicant: MonsterGecko, LLCInventors: Jeff Ma, Ain McKendrick, Robert Yuan
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Publication number: 20050099390Abstract: A device for providing user input to a computer has a trigger disposed on a forward surface of a vertically oriented grip member so that the trigger is operable by a first finger of a user's hand, and button input signals are generated in response to operation of the trigger. A scroll wheel is rotatably mounted on the grip member and is positioned so as to be operable by the user's thumb, and scroll input signals are generated in response to operation of the scroll wheel.Type: ApplicationFiled: November 5, 2004Publication date: May 12, 2005Applicant: MonsterGecko, LLCInventors: Jeff Ma, Ain McKendrick, Robert Yuan
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Publication number: 20050099389Abstract: A device for providing user input to a computer includes a base member with a tracking sensor for detecting motion of the base member and a vertical grip member that extends upward from the base member. A scroll wheel is rotatably mounted in the grip member and oriented so as to be rotatable by a substantially arc-like movement of a thumb of a hand holding the grip member.Type: ApplicationFiled: November 5, 2004Publication date: May 12, 2005Applicant: MonsterGecko, LLCInventors: Jeff Ma, Ain McKendrick, Robert Yuan
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Patent number: 6660228Abstract: The present invention provides an apparatus for performing heat-exchanging chemical reactions, such as nucleic acid amplification. The apparatus includes a reaction vessel having a chamber for holding a sample for chemical reaction and optical detection. The vessel has a rigid frame defining the side walls of the chamber, and flexible sheets attached to opposite sides of the frame to form opposing major walls of the chamber. The frame further includes a port and a channel connecting the port to the chamber. The temperature of the sample is controlled by opposing plates positioned to receive the chamber of the vessel between them. The apparatus also includes a plunger which is inserted into the channel of the vessel to seal the port and increase pressure in the chamber. The increased pressure forces the flexible major walls of the chamber to contact and conform to the surfaces of the plates, thus ensuring optimal thermal conductance between the plates and the chamber.Type: GrantFiled: December 21, 1999Date of Patent: December 9, 2003Assignee: CepheidInventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
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Publication number: 20030152492Abstract: This invention provides an apparatus for rapidly heating and/or cooling a sample in a reaction vessel. In some embodiments, the apparatus includes optics for the efficient detection of a reaction product in the vessel. The invention also provides a reaction vessel having a reaction chamber designed for optimal thermal conductance and for efficient optical viewing of reaction products in the chamber.Type: ApplicationFiled: March 3, 2003Publication date: August 14, 2003Applicant: CepheidInventors: Ronald Chang, Lee A. Christel, Gregory T.A. Kovacs, William A. McMillan, M. Allen Northrup, Kurt E. Petersen, Farzad Pourahmadi, Steven J. Young, Robert Yuan, Douglas B. Dority
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Patent number: D518056Type: GrantFiled: February 5, 2004Date of Patent: March 28, 2006Assignee: MonsterGecko, LLCInventors: Jeffrey Ma, Ain McKendrick, Robert Yuan