Abstract: The invention relates to a mouse double minute 2 (MDM2) inhibitor for use in the treatment and/or prevention of a hematologic neoplasm relapse after hematopoietic cell transplantation (HCT) in a patient. In embodiments, the hematologic neoplasm is a leukaemia, preferably acute myeloid leukaemia (AML). Preferably, the patient received an allogeneic T cell transplantation, either together with the HCT and/or after HCT, such as at the time point of MDM2 administration.

Abstract: The present invention relates to a method comprising the steps of provision of a sample derived from a blood sample of a subject that has received a checkpoint-inhibitor therapy and is suspected of developing or has developed symptoms of an immune-related adverse event (irAE), adding 8-methoxypsoralen to the sample, and subjecting the sample to UVA irradiation. In another aspect, the invention comprises administering a treatment procedure on consecutive days, during the checkpoint-inhibitor therapy or after discontinuation of the checkpoint-inhibitor therapy.

Abstract: The present invention relates to a method comprising the steps of provision of a sample derived from a blood sample of a subject that has received a checkpoint-inhibitor therapy and is suspected of developing or has developed symptoms of immune-related adverse events (irAE), adding a photosensitizing agent to the sample, and subjecting the sample to irradiation, which preferably generates immunoregulatory NK cells in said sample. In embodiments, the photosensitizing agent is 8-methoxypsoralen and/or the irradiation is UVA irradiation. In another aspect, the invention relates to immunoregulatory NK cells obtained from a method comprising the steps of provision of a sample derived from an isolated blood sample of a subject, adding a photosensitizing agent to the sample, and subjecting the sample to irradiation. Furthermore, the invention encompasses immunoregulatory NK cells for use in the treatment and/ or prevention of irAE in a subject that has received a checkpoint-inhibitor therapy.

Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.

Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.

Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.

Abstract: A device for cleaning debris from a target surface. The device has a handle for gripping by a user, a hole in the handle which removably receives a replaceable container of cleaning solution and a flat surface which removably receives a cleaning pad. This device may be extruded from a monolithic piece of material, cut to length. The resulting device is unitary, inexpensive and durable. The pad/cleaning solution may be replaced when depleted and replaced with a new pad/cleaning solution or may simply be replaced with a new pad/cleaning solution as may be more suitable for a particular cleaning task. The device may be foam, which provides for an inexpensive construction material and convenient, ergonomic gripping.

Abstract: A device for cleaning debris from a target surface. The device has a handle for gripping by a user, a hole which removably receives a replaceable container of cleaning solution and a flat surface which removably receives a cleaning pad. The device may made of any compliant material, preferably resilient, and comprise two or more pieces, particularly an elongate tubular member and a sole plate, permanently joined together. The pad/cleaning solution may be replaced when depleted and replaced with a new pad/cleaning solution or may simply be replaced with a new pad/cleaning solution as may be more suitable for a particular cleaning task. The device may be foam, which provides for an inexpensive construction material and convenient, ergonomic gripping.

Abstract: A device for cleaning debris from a target surface. The device has a handle for gripping by a user, a hole in the handle which removably receives a replaceable container of cleaning solution and a flat surface which removably receives a cleaning pad. This device may be extruded from a monolithic piece of material, cut to length. The resulting device is unitary, inexpensive and durable. The pad/cleaning solution may be replaced when depleted and replaced with a new pad/cleaning solution or may simply be replaced with a new pad/cleaning solution as may be more suitable for a particular cleaning task. The device may be foam, which provides for an inexpensive construction material and convenient, ergonomic gripping.