Abstract: The present invention provides a novel myomegalin isoform—myomegalin variant 8 (MMG8). The myomegalin variant 8 regulates microtubule organization at the Golgi apparatus, protein modification, secretion and trafficking, and cell proliferation. The present invention also provides nucleic acid molecules encoding the myomegalin isoforms, and vectors and host cells containing the nucleic acid molecules. Also provided are fusion constructs comprising the myomegalin isoform and antibodies that bind specifically to the myomegalin isoforms of the present invention. The present invention further provides uses of the myomegalin isoform as a diagnostic biomarker and as a target for screening for therapeutics for diseases such as cancer, diabetes, and lysosomal storage diseases.

Abstract: Cageless toilet dispensing devices for use in conjunction with a sanitary appliance particularly a toilet, and methods for their use.

Abstract: The present invention relates to a process for the production of improved toilet dispensing devices for use in conjunction with a sanitary appliance particularly a toilet, and methods of using the same.

Abstract: The present invention relates to a method for the manufacture of a lavatory dispensing device useful for the delivery of at least one treatment composition, preferably a cleaning composition and/or a sanitizing composition to a sanitary appliance.

Abstract: The present invention relates to a cageless lavatory dispensing device comprising a hanger (10) and a compressed solid block (50). The hanger (10) has a hook end (20) for suspending the dispensing device to a sanitary-appliance, and the compressed solid block (50) comprises at least one chemical agent. A process for delivering a treatment composition to a sanitary appliance is also disclosed. Said process comprises the steps of: providing and suspending a cageless lavatory dispensing device within the sanitary appliance; periodically flushing water about the exterior of the compressed block to elute at least one chemical constituent to form a treatment composition with said water, which treatment composition provides cleaning and/or sanitizing and/or disinfecting benefit to the sanitary appliance.

Abstract: The present invention provides a novel myomegalin isoform—myomegalin variant 8 (MMG8). The myomegalin variant 8 regulates microtubule organization at the Golgi apparatus, protein modification, secretion and trafficking, and cell proliferation. The present invention also provides nucleic acid molecules encoding the myomegalin isoforms, and vectors and host cells containing the nucleic acid molecules. Also provided are fusion constructs comprising the myomegalin isoform and antibodies that bind specifically to the myomegalin isoforms of the present invention. The present invention further provides uses of the myomegalin isoform as a diagnostic biomarker and as a target for screening for therapeutics for diseases such as cancer, diabetes, and lysosomal storage diseases.

Abstract: Improved treatment blocks useful in the treatment of lavatory appliances, particularly toilets are provided. The improved treatment blocks are solid block compositions which comprise at least one detersive surfactant, a film forming constituent, optionally a bleach constituent and one or more further optional constituents. The improved treatment blocks provide good detersive characteristics and further provide a film forming material which contacts the surfaces of the lavatory appliance, e.g., toilet, in which the block compositions are used. Methods of producing the solid block composition and treatment blocks therefrom, as well as methods of use are also disclosed.

Abstract: The present invention relates to a method for the manufacture of a lavatory dispensing device useful for the delivery of at least one treatment composition, preferably a cleaning composition and/or a sanitizing composition to a sanitary appliance.

Abstract: The present invention relates to a method for the manufacture of a lavatory dispensing device useful for the delivery of at least one treatment composition, preferably a cleaning composition and/or a sanitizing composition to a sanitary appliance.

Abstract: The present invention relates to a method for the manufacture of a lavatory dispensing device useful for the delivery of at least one treatment composition, preferably a cleaning composition and/or a sanitizing composition to a sanitary appliance.

Abstract: The present invention relates to a process for the production of improved toilet dispensing devices for use in conjunction with a sanitary appliance particularly a toilet, and methods of using the same.

Abstract: The present invention relates to improved toilet dispensing devices for use in conjunction with a sanitary appliance particularly a toilet, and methods for their use.

Abstract: Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.

Abstract: Lavatory treatment blocks which provide improved foaming benefit and improved foam substantivity are provided. The lavatory treatment blocks may be used with or without a lavatory treatment device, such as an in the bowl type, or in the cistern type device. Preferred embodiments of the lavatory treatment blocks provide a cleaning and/or sanitizing and/or disinfecting benefit to a sanitary appliance being treated using the lavatory treatment blocks.

Abstract: Improved treatment blocks useful in the treatment of lavatory appliances, particularly toilets are provided. The improved treatment blocks are solid block compositions which comprise at least one detersive surfactant, a film forming constituent, optionally a bleach constituent and one or more further optional constituents. The improved treatment blocks provide good detersive characteristics and further provide a film forming material which contacts the surfaces of the lavatory appliance, e.g., toilet, in which the block compositions are used. Methods of producing the solid block composition and treatment blocks therefrom, as well as methods of use are also disclosed.

Abstract: The present invention relates to improved toilet dispensing devices for use in conjunction with a sanitary appliance, particularly a toilet.

Abstract: The present invention relates to a cageless lavatory dispensing device comprising a hanger (10) and a compressed solid block (50). The hanger (10) has a hook end (20) for suspending the dispensing device to a sanitary-appliance, and the compressed solid block (50) comprises at least one chemical agent. A process for delivering a treatment composition to a sanitary appliance is also disclosed. Said process comprises the steps of: providing and suspending a cageless lavatory dispensing device within the sanitary appliance; periodically flushing water about the exterior of the compressed block to elute at least one chemical constituent to form a treatment composition with said water, which treatment composition provides cleaning and/or sanitizing and/or disinfecting benefit to the sanitary appliance.

Abstract: Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.

Abstract: Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.

Abstract: Foamed two-part hard surface treatment composition which is formed by the admixture of two aqueous compositions, particularly (a) an aqueous alkaline composition comprising a bleach constituent, with (b) an aqueous acidic composition comprising a peroxide constituent, which compositions are kept separate, but which are admixed immediately prior to use or upon use to form a foamed hard surface treatment composition. The foamed two-part hard surface treatment composition are particularly useful in the cleaning of hard surfaces. Preferred foamed two-part hard surface treatment composition provide both a cleaning and sanitizing or disinfecting benefit to hard surfaces, while releasing little or no free chlorine gas to the ambient air.