Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Disclosed herein are antibodies, pharmaceutical formulations for treating or preventing Alzheimer's disease, methods of treating or preventing Alzheimer's disease, and kits comprising pharmaceutical formulations for treating or preventing Alzheimer's Disease comprising an anti-A? protofibril antibody and anti-tau antibody.

Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.

Abstract: A database management system is described that can encode data to generate a plurality of data vectors. The database management system can perform the encoding by using a dictionary. The database management system can adaptively reorder the plurality of data vectors to prepare for compression of the plurality of data vectors. During a forward pass of the adaptive reordering, most frequent values of a data vector of the plurality of data vectors can be moved-up in the data vector. During a backward pass of the adaptive reordering, content within a rest range of a plurality of rest ranges can be rearranged within the plurality of data vectors according to frequencies of the content. The reordering according to frequency can further sort the rest range by value. Related apparatuses, systems, methods, techniques, computer programmable products, computer readable media, and articles are also described.

Abstract: A system and method is disclosed for determining an optimal direction and a minimum directional negative distance between two objects. The system and method uses an iterative process involving rotating a vector about two or more axes to obtain a group of new vectors, determining which one of the new group of vectors has the smallest directional negative distance, comparing the vector having the smallest directional negative distance to a preset value, and repeating the above operations as needed until a vector is obtained which does not exceed the preset value, and which is then identified as the optimum directional vector having a minimal directional negative value.

Abstract: A rehabilitation system includes a portable patient workstation configured to facilitate in-home rehabilitation therapy. In some embodiments, the workstation includes a computer configured to host computer-based activities that provide rehabilitative exercise to a patient when the patient participates in the activities, a monitor electrically connected to the computer and configured to display screens of the computer-based activities, a table upon which the monitor can be supported, a tabletop console supported on the table, the console including multiple integral user interface devices that are connected to the computer and adapted to receive patient inputs while the patient is participating in the activities, and a network interface device with which data can be transmitted and received by the patient workstation via a network.

Abstract: A system and method is disclosed for determining an optimal direction and a minimum directional negative distance between two objects. The system and method uses an iterative process involving rotating a vector about two or more axes to obtain a group of new vectors, determining which one of the new group of vectors has the smallest directional negative distance, comparing the vector having the smallest directional negative distance to a preset value, and repeating the above operations as needed until a vector is obtained which does not exceed the preset value, and which is then identified as the optimum directional vector having a minimal directional negative value.

Abstract: A rehabilitation system includes a portable patient workstation configured to facilitate in-home rehabilitation therapy. In some embodiments, the workstation includes a computer configured to host computer-based activities that provide rehabilitative exercise to a patient when the patient participates in the activities, a monitor electrically connected to the computer and configured to display screens of the computer-based activities, a table upon which the monitor can be supported, a tabletop console supported on the table, the console including multiple integral user interface devices that are connected to the computer and adapted to receive patient inputs while the patient is participating in the activities, and a network interface device with which data can be transmitted and received by the patient workstation via a network.

Abstract: A method for determining a mated portion of an object can include receiving design data defining a three-dimensional object having a first member mated with a second member. Each member can be represented by a plurality of triangles. The method can include determining an outer layer of the three-dimensional object and a mated surface of the three-dimensional object. The mated surface may be determined by utilizing a recursive process to analyze each specific triangle of the plurality of triangles. The recursive process can classify a triangle as: (i) on the outer layer when all of its vertices are on the outer layer, and (ii) in the mated surface when none of its vertices are on the outer layer. When a triangle has at least one but not all of its vertices on the outer layer, the triangle can be subdivided into sub-triangles, which are then analyzed individually.

Abstract: A system and method for generating a representation of an outer layer of a three-dimensional object is disclosed. The object may be represented by a data structure that defines a plurality of triangles that collectively represent the object. The method comprises receiving the data structure and determining a bounding box that can encapsulate the object, the bounding box being comprised of a plurality of voxels. The method further comprises determining an intersecting set of voxels of the plurality of voxels. A member of the intersecting set of voxels intersects with at least one triangle of the plurality of triangles. The method also includes determining an outer set of voxels from the intersecting set of voxels, wherein a member of the outer set of voxels shares a face with a voxel that is not a member of the intersecting set of voxels. The method further includes determining an outer layer set of triangles from the plurality of triangles to obtain a modified data structure.

Abstract: An iterative process for determining an aperture in a representation of an object is disclosed. The object is received and a bounding box corresponding thereto is determined. The bounding box includes a plurality of initial voxels and the object is embedded therein. An intersecting set of initial voxels is determined, as well as an internal set and an external set of initial voxels. The resolution of the voxels is iteratively decreased until the ratio of internal voxels to external voxels exceeds a predetermined threshold. The voxels corresponding to the final iteration are the final voxels. An internal set of final voxels is determined. A union set of initial voxels is determined indicating an intersection between the external set of initial voxels and the internal set of final voxels. From the union set of initial voxels and the external set of initial voxels, a location of an aperture is determined.

Abstract: A method for determining a mated portion of an object can include receiving design data defining a three-dimensional object having a first member mated with a second member. Each member can be represented by a plurality of triangles. The method can include determining an outer layer of the three-dimensional object and a mated surface of the three-dimensional object. The mated surface may be determined by utilizing a recursive process to analyze each specific triangle of the plurality of triangles. The recursive process can classify a triangle as: (i) on the outer layer when all of its vertices are on the outer layer, and (ii) in the mated surface when none of its vertices are on the outer layer. When a triangle has at least one but not all of its vertices on the outer layer, the triangle can be subdivided into sub-triangles, which are then analyzed individually.

Abstract: A system and method for generating a representation of an outer layer of a three-dimensional object is disclosed. The object may be represented by a data structure that defines a plurality of triangles that collectively represent the object. The method comprises receiving the data structure and determining a bounding box that can encapsulate the object, the bounding box being comprised of a plurality of voxels. The method further comprises determining an intersecting set of voxels of the plurality of voxels. A member of the intersecting set of voxels intersects with at least one triangle of the plurality of triangles. The method also includes determining an outer set of voxels from the intersecting set of voxels, wherein a member of the outer set of voxels shares a face with a voxel that is not a member of the intersecting set of voxels. The method further includes determining an outer layer set of triangles from the plurality of triangles to obtain a modified data structure.

Abstract: A water saving device and method of using same. The water saving device includes a sleeve and an elastomer fixed in the sleeve. The elastomer has at least a permanently-open hole, a throttling hole and a protrusion for arranging the permanently-open hole and the throttling hole. The permanently-open hole is a hole which still maintains open status after being distorted by pressure. The throttling hole is a hole which will be closed approximately after distortion by pressure. The water saving device not only has the function of decreasing the flow, but also can adjust the flow of the shower and faucet to make the flow steady.

Abstract: An iterative process for determining an aperture in a representation of an object is disclosed. The object is received and a bounding box corresponding thereto is determined. The bounding box includes a plurality of initial voxels and the object is embedded therein. An intersecting set of initial voxels is determined, as well as an internal set and an external set of initial voxels. The resolution of the voxels is iteratively decreased until the ratio of internal voxels to external voxels exceeds a predetermined threshold. The voxels corresponding to the final iteration are the final voxels. An internal set of final voxels is determined. A union set of initial voxels is determined indicating an intersection between the external set of initial voxels and the internal set of final voxels. From the union set of initial voxels and the external set of initial voxels, a location of an aperture is determined.

Abstract: A hand held shower with a button switching mechanism for switching spray patterns disclosed in the present invention comprises a body, a button switching mechanism and a cover unit. The button switching mechanism comprises a seat, a disc, a lever, a button, a lower ratchet wheel sleeve and an upper wheel bar. Each time the button pressed, the disc will be rotated to a certain angle so that the outlet hole of the disc will align with the different inlets of seat. The inlets of the seat and the channels with different functions of the cover unit cooperate to switch the spray pattern. The spray pattern can be conveniently and accurately switched by pressing the button with one hand and with little effort.

Abstract: A hand held shower with a button switching mechanism for switching spray patterns disclosed in the present invention comprises a body, a button switching mechanism and a cover unit. The button switching mechanism comprises a seat, a disc, a lever, a button, a lower ratchet wheel sleeve and an upper wheel bar. Each time the button pressed, the disc will be rotated to a certain angle so that the outlet hole of the disc will align with the different inlets of seat. The inlets of the seat and the channels with different functions of the cover unit cooperate to switch the spray pattern. The spray pattern can be conveniently and accurately switched by pressing the button with one hand and with little effort.

Abstract: A water saving device and method of using same disclosed in the present invention, wherein the water saving device comprising a sleeve (2) and an elastomer (1) fixed in said sleeve (2), said elastomer (1) having at least a permanently-open hole (13), a throttling hole (14) and a protrusion (12) for arranging said permanently-open hole (13) and/or throttling hole (14); said permanently-open hole (13) is a hole which still maintain open status after being distorted by pressure, said throttling hole (14) is a hole which will be closed approximately after distortion by pressure. The water saving device not only has the function of decreasing the flow, but also can adjust the flow of the shower and faucet to make the flow steady.