Patents by Inventor Roberta Baronio

Roberta Baronio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecules to enhance P53 activity
    Patent number: 9737546
    Abstract: A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.
    Type: Grant
    Filed: August 9, 2014
    Date of Patent: August 22, 2017
    Assignee: The Regents of the University of California
    Inventors: Rommie E. Amaro, Roberta Baronio, Ozlem Demir, Peter Kaiser, Richard H. Lathrop, Seyedey-Faezeh Salehi-Amin, Christopher D. Wassman
  • SMALL MOLECULES TO ENHANCE P53 ACTIVITY
    Publication number: 20160193214
    Abstract: A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.
    Type: Application
    Filed: August 9, 2014
    Publication date: July 7, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rommie E. Amaro, Roberta Baronio, Ozten Demir, Peter Kaiser, Richard H. Lathrop, Seyedeh-Feezeh Salehi-Amin, Christopher D. Wassman
  • SMALL MOLECULES FOR RESTORING FUNCTION TO P53 CANCER MUTANTS
    Publication number: 20150307519
    Abstract: Embodiments of the present provide methods of inducing p53 SRMMP-dependent cancer cell cytotoxicity. Such methods involve the steps of exposing a cancer cell that comprises a p53 SRMMP to an amount of a chemical compound sufficient to induce p53 SRMMP-dependent cancer cell cytotoxicity. In one embodiment, the present invention provides a method of treating cancer by determining the presence of a p53 mutation, and administering a therapeutically effective dosage of a composition comprising one or more promoting compounds.
    Type: Application
    Filed: April 28, 2015
    Publication date: October 29, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Hartmut Luecke, Brad Wallentine, Chiung-Kuang Chen, Roberta Baronio, Peter Kaiser