Patents by Inventor Roberta Castriconi

Roberta Castriconi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IGG DERIVED B7-H3-SPECIFIC CHIMERIC ANTIGEN RECEPTOR (B7-H3 CAR) EFFECTOR CELLS FOR THE TREATMENT OF CD276+ TUMORS AND AUTOIMMUNE DISEASES
    Publication number: 20260209356
    Abstract: The present invention concerns a vector including the cassette coding for B7-H3 CAR gene obtained using the single chains variable fragments (scFv) of the monoclonal IgG antibody NE97, a method for the production thereof and B7-H3 CAR genetically modified effector cells (such as T cells or innate cells such as NK and NK-T cells) for the treatment of CD276 (B7-H3) positive tumors such as lymphoid malignancies, leukemia and solid tumors such as CNS tumors, extra-cranial and intracranial tumors and autoimmune diseases.
    Type: Application
    Filed: December 13, 2023
    Publication date: July 23, 2026
    Inventors: Franco LOCATELLI, Concetta QUINTARELLI, Biagio DE ANGELIS, Ignazio CARUANA, Lorenzo MORETTA, Cristina BOTTINO, Roberta CASTRICONI
  • THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS TARGETING 4IG-B7-H3 AND ITS COUNTERPART NK CELL RECEPTOR
    Publication number: 20130315892
    Abstract: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.
    Type: Application
    Filed: June 7, 2013
    Publication date: November 28, 2013
    Inventors: ALESSANDRO MORETTA, ROBERTA CASTRICONI, CHRISTINA BOTTINO, LORENZO MORETTA
  • Therapeutic and diagnostic methods and compositions targeting 4Ig-B7-H3 and its counterpart NK cell receptor
    Patent number: 8465931
    Abstract: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: June 18, 2013
    Assignees: Innate Pharma S.A., University of Genova
    Inventors: Alessandro Moretta, Roberta Castriconi, Christina Bottino, Lorenzo Moretta
  • Therapeutic and Diagnostic Methods and Compositions Targeting 4Ig-B7-H3 and its Counterpart NK Cell Receptor
    Publication number: 20100285531
    Abstract: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.
    Type: Application
    Filed: May 7, 2010
    Publication date: November 11, 2010
    Applicants: INNATE PHARMA S.A., UNIVERSITA DI GENOVA
    Inventors: Alessandro Moretta, Roberta Castriconi, Christina Bottino, Lorenzo Moretta
  • Therapeutic and diagnostic methods and compositions targeting 4Ig-B7-H3 and its counterpart NK cell receptor
    Patent number: 7732131
    Abstract: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: June 8, 2010
    Assignees: Innate Pharma S.A., University of Genova
    Inventors: Alessandro Moretta, Roberta Castriconi, Christina Bottino, Lorenzo Moretta
  • Therapeutic and Diagnostic Methods and Compositions Targeting 4Ig-B7-H3 and its Counterpart Nk Cell Receptor
    Publication number: 20080081346
    Abstract: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.
    Type: Application
    Filed: August 2, 2005
    Publication date: April 3, 2008
    Applicants: Innate Pharma S.A., Universita Di Genova
    Inventors: Alessandro Moretta, Roberta Castriconi, Christina Bottino, Lorenzo Moretta