Abstract: The present disclosure relates to field of lyophilized/freeze-dried viral combination composition/formulation and methods for manufacturing and obtaining the composition comprising at least three live attenuated virus selected from a group of Coronavirus, Measles virus and Rubella virus; and stabilizers comprising of at least one carbohydrate, at least one amino acid and at least one hydrolyzed protein. The said lyophilized/freeze-dried viral combination composition/formulation is a vaccine composition that preserves the desired characteristics of each virus, including stability and immunogenicity. The composition can be safely administered subcutaneously as a combination vaccine composition such that the immunogenicity of each of the measles, rubella and SARS-CoV-2 is not inferior to that observed for each of the three viruses when administered as individual vaccines and is found to be equivalent or improved as compared to immunogenicity of SARS-CoV-2 vaccine given intranasally.

Abstract: The present invention provides for parenterally administrable live attenuated influenza immune compositions. Methods of using parenterally administrable live attenuated influenza immune compositions to elicit an immune response, and particularly, a protective immune response are also provided.

Abstract: A method includes obtaining first code in a high-level programming language. The first code represents a first function for performing one or more operations on plaintext. The method also includes converting the first code into an intermediate representation comprising a list of nodes. Each node of the list of nodes includes one or more logical operations. The method also includes converting the intermediate representation into a Boolean intermediate representation that includes a plurality of single-bit logical operations. The method also includes transpiling the Boolean intermediate representation into second code in the high-level programming language. The second code represents a second function for performing, using fully homomorphic encryption (FHE), the one or more operations on ciphertext.

Abstract: The present invention is the use of designed recombinant viruses for the treatment of various forms of malignant tumors. The recombinant viruses of the invention are those in which one or more regions of the wild type virus was exchanged with a synthetic recoded sequence that reduces the codon pair score relative to human codon pair bias, or that increase the number for CpG di-nucleotides, or that increases the number of UpA di-nucleotides. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, skin, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, as well as for the treatment of breast cancer and melanoma as well.

Abstract: The present invention provides for modified Flavivirus such as a modified Zika virus. The modification according to various aspects of the invention results in reduced viral proteins compared to a parent virus, wherein the reduction in expression is the result of recoding one or more regions of the virus. For example, the prM, or envelope (E) region, or the nonstructural protein 3 (NS3) region or both the E and NS3 regions can be recoded. In various embodiments one or more regions are recoded by reducing the codon pair bias or codon usage bias of the protein-encoding sequence. These modified Flavivirus are used as vaccine compositions to provide a protective immune response.

Abstract: A monolithic concrete modular connecting panel system for walls and roofs includes a foundation for a building, wall panels vertically aligned on the foundation and secured to the foundation to form a perimeter of the building. The system includes a plurality of roof panels secured to a top edge of the wall panels and spanning across the perimeter of the building. A plurality of crisscrossing rebar rods and wire mesh within the wall panels and roof panels are connected together with rebar rods of the foundation to form a steel cage for the building. Each wall and roof panel includes a metal frame, and a concrete board that divides the metal frames into an inner section and an outer section. In addition, the system includes concrete sprayed on the outer sections of the wall panels and sprayed or poured on the roof panels to form a monolithic concrete structure.

Abstract: A method includes obtaining first code in a high-level programming language. The first code represents a first function for performing one or more operations on plaintext. The method also includes converting the first code into an intermediate representation comprising a list of nodes. Each node of the list of nodes includes one or more logical operations. The method also includes converting the intermediate representation into a Boolean intermediate representation that includes a plurality of single-bit logical operations. The method also includes transpiling the Boolean intermediate representation into second code in the high-level programming language. The second code represents a second function for performing, using fully homomorphic encryption (FHE), the one or more operations on ciphertext.

Abstract: Described herein are modified SARS-CoV-2 variants. These viruses have been recoded, for example, codon deoptimized or codon pair bias deoptimized and are useful for reducing the likelihood or severity of a SARS-CoV-2 variant infection, preventing a SARS-CoV-2 variant infection, eliciting and immune response, or treating a SARS-CoV-2 variant infection.

Abstract: The present invention relates to deoptimized Yellow Fever viruses and their uses for the treatment of various forms of malignant tumors, and as vaccines against Yellow Fever. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, skin, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain.

Abstract: Systems and methods are provided for a head-wearable device. The head-wearable device can include a display, a retractable side strap, and a housing. The housing includes an anchor point, an adjustment mechanism configured to change an exposed length of the retractable side strap, and a cable. The cable includes a first end and a second end coupled the cable-spooling portion of the adjustment mechanism and an intermediary portion of the cable that travels around the anchor point and is coupled to the retractable side strap. The cable is maintained at a predetermined tension by at least the adjustment mechanism or the anchor point. When the adjustment mechanism is adjusted, the cable winds/unwinds around the first or second cable-spooling portion of the adjustment mechanism, adjusting the exposed length of the retractable side strap to accommodate for different head sizes for users of the head-wearable device.

Abstract: A linear actuation mechanism includes a first threaded rod rotatably fixed on a frame, an actuator mechanically coupled to the first threaded rod and configured to cause a rotation thereof, a first nut threaded onto the first threaded rod and attached to a first eyecup configured to hold a first optical element for a headset display, and a rail on the frame configured to support the first eyecup as it moves with the first nut. A headset including a display and two eyepieces supported by at least the first eyecup and the above linear actuation mechanism, and a method for using the linear actuation mechanism to adjust an inter-axial distance between the eyepieces are also provided.

Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

Abstract: The present invention provides for methods of vaccination and eliciting a IgA immune response and cellular immune response, including T-cell immune response by administering a deoptimized respiratory syncytial virus (RSV).

Abstract: Aspects of the present disclosure are directed to an adjustment mechanism for adjusting an eye-to-lens distance of a headset display device. The adjustment mechanism can include an adjustment wheel that is rotatable by a user, a pinion gear fixed to a screw, and a threaded member receiving the screw and mounted to a forehead pad frame supporting a forehead pad. The adjustment wheel can include an internal bevel gear ring. The pinion gear is rotated by rotation of the internal bevel gear ring, and the screw rotates with the pinion gear. The pinion gear and the screw can rotate about a second axis. The threaded member moves along the screw, as the screw rotates, to move the forehead pad to adjust the eye-to-lens distance. The internal bevel gear ring, the pinion gear, and the screw are configured to allow additional components to pass through an interior of the adjustment wheel.

Abstract: A method includes obtaining first code in a high-level programming language. The first code represents a first function for performing one or more operations on plaintext. The method also includes converting the first code into an intermediate representation comprising a list of nodes. Each node of the list of nodes includes one or more logical operations. The method also includes converting the intermediate representation into a Boolean intermediate representation that includes a plurality of single-bit logical operations. The method also includes transpiling the Boolean intermediate representation into second code in the high-level programming language. The second code represents a second function for performing, using fully homomorphic encryption (FHE), the one or more operations on ciphertext.

Abstract: Expandable band systems for wearable devices, such as spatial computing headsets, are provided which have flexible and conformable form factors that enable users to reliably to secure such wearable devices in place. Further, in the context of spatial computing headsets with an optics assembly supported by opposing temple arms, the expandable band systems provide protection against over-extension of the temple arms or extreme deflections that may otherwise arise from undesirable torsional loading of the temple arms.

Abstract: A method includes obtaining first code in a high-level programming language. The first code represents a first function for performing one or more operations on plaintext. The method also includes converting the first code into an intermediate representation comprising a list of nodes. Each node of the list of nodes includes one or more logical operations. The method also includes converting the intermediate representation into a Boolean intermediate representation that includes a plurality of single-bit logical operations. The method also includes transpiling the Boolean intermediate representation into second code in the high-level programming language. The second code represents a second function for performing, using fully homomorphic encryption (FHE), the one or more operations on ciphertext.

Abstract: A heavy vehicle and machinery trailer having: (i) a trailer base with wheels and suspension; (ii) a trailer bed supported on the trailer base by the suspension; (iii) loading ramps connected to the trailer bed where the suspension, or other methods such as hydraulically operated landing legs, are adapted to allow an operator to alter the pitch and/or roll angle of the trailer bed relative to the ground surface and wherein where the loading ramps are adapted to have varying lengths such that the ramps can be evenly pitched when they are extended to the ground on a sloped surface. The trailer has a hydraulic system under the control of an electrical controller which is operated by a user. The electrical controller has a preset matrix of safe loading and unloading parameters which it uses to determine whether the sensed state of the trailer is safe for loading or unloading.

Abstract: A visual perception device is described. The visual perception device has corrective optics for viewing virtual and real-world content. An insert for the corrective optics is attached using a magnetic set, pins and/or a nose piece. Interchangeable nose pieces allow for height adjustments to accommodate different users. The visual perception device has pliable components to absorb forces exerted on a nose piece and a protective barrier for limiting electric shock or ingress of dirt.

Abstract: The present invention describes methods of generating a modified viral genome, producing infectious RNA, and generating modified viruses. The modified viral genome, infections RNA, and modified viruses comprise deoptimized nucleic acids; for example, codon-pair deoptimized or synonymous codon deoptimized. These modified viruses can be used in vaccines and methods of eliciting a protective immune response.