Abstract: Neurophysiological stimulation device includes: an anvil-profiled portion having two ends, a curved portion profiled as an arc and having a convex end and a flat or concave end, an incision present on the curved portion following the same curvature of the latter, the anvil and curved portions forming a single body, and being firmly joined together by having an end of the anvil portion joined with the convex end of the curved portion which represents the occlusion zone of the bite of the user, the curved portion having the incision extended from one canine tooth to the other at the time of application of the device to the subject user, the flat or concave end extended inside the mouth with respect to the teeth of the subject and the convex end extended outside the teeth of the user, the incision being delimited by the ends of the curved portion.