Patents by Inventor Roberta Fretta
Roberta Fretta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11905257Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.Type: GrantFiled: December 1, 2021Date of Patent: February 20, 2024Assignee: BRACCO IMAGING S.P.A.Inventors: Roberta Fretta, Luciano Lattuada, Gabriele Meli
-
Publication number: 20230391735Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.Type: ApplicationFiled: December 1, 2021Publication date: December 7, 2023Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta FRETTA, Luciano LATTUADA, Gabriele MELI
-
Patent number: 11691875Abstract: The invention relates to a process for the recovery and recycling of the iodine from aqueous solutions comprising iodine-comprising aromatic compounds in which the iodine contained in said aromatic compounds is directly converted into molecular iodine at a pH lower than 1, in the absence of a catalyst.Type: GrantFiled: June 7, 2018Date of Patent: July 4, 2023Assignee: BRACCO IMAGING SPAInventors: Laura Galimberti, Andrea Banin, Sonia Gazzetto, Fernanda Di Giorgio, Roberta Fretta
-
Patent number: 11667601Abstract: The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.Type: GrantFiled: December 17, 2020Date of Patent: June 6, 2023Assignee: BRACCO IMAGING S.P.A.Inventors: Andrea Banin, Laura Galimberti, Roberta Napolitano, Roberta Fretta
-
Publication number: 20230046541Abstract: The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.Type: ApplicationFiled: December 17, 2020Publication date: February 16, 2023Applicant: BRACCO IMAGING S.P.A.Inventors: Andrea BANIN, Laura GALIMBERTI, Roberta NAPOLITANO, Roberta FRETTA
-
Patent number: 11014942Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.Type: GrantFiled: November 8, 2019Date of Patent: May 25, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Roberta Mazzon, Roberta Fretta, Pier Lucio Anelli
-
Patent number: 10836710Abstract: The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.Type: GrantFiled: December 4, 2017Date of Patent: November 17, 2020Assignee: BRACCO IMAGING SPAInventors: Alessandro Barge, Francesca Baricco, Giancarlo Cravotto, Roberta Fretta, Luciano Lattuada
-
Patent number: 10738000Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: GrantFiled: February 14, 2019Date of Patent: August 11, 2020Assignee: Bracco Imaging SpAInventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
-
Publication number: 20200131036Abstract: The invention relates to a process for the recovery and recycling of the iodine from aqueous solutions comprising iodine-comprising aromatic compounds in which the iodine contained in said aromatic compounds is directly converted into molecular iodine at a pH lower than 1, in the absence of a catalyst.Type: ApplicationFiled: June 7, 2018Publication date: April 30, 2020Applicant: BRACCO IMAGING SPAInventors: Laura GALIMBERTI, Andrea BANIN, Sonia GAZZETTO, Fernanda DI GIORGIO, Roberta FRETTA
-
Publication number: 20200079728Abstract: The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.Type: ApplicationFiled: December 4, 2017Publication date: March 12, 2020Applicant: BRACCO IMAGING SPAInventors: Alessandro BARGE, Francesca BARICCO, Giancarlo CRAVOTTO, Roberta FRETTA, Luciano LATTUADA
-
Publication number: 20200071341Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta MAZZON, Roberta FRETTA, Pier Lucio ANELLI
-
Patent number: 10519171Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.Type: GrantFiled: July 20, 2015Date of Patent: December 31, 2019Assignee: BRACCO IMAGING S.P.A.Inventors: Roberta Mazzon, Roberta Fretta, Pier Lucio Anelli
-
Publication number: 20190225570Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: ApplicationFiled: February 14, 2019Publication date: July 25, 2019Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
-
Patent number: 10246400Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: GrantFiled: April 5, 2018Date of Patent: April 2, 2019Assignee: Bracco Imaging S.P.A.Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
-
Publication number: 20180222840Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: ApplicationFiled: April 5, 2018Publication date: August 9, 2018Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
-
Patent number: 9963416Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: GrantFiled: June 10, 2015Date of Patent: May 8, 2018Assignee: Bracco Imaging S.P.A.Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
-
Patent number: 9795695Abstract: The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.Type: GrantFiled: April 15, 2016Date of Patent: October 24, 2017Assignee: BRACCO IMAGING S.p.A.Inventors: Pier Lucio Anelli, Pierfrancesco Morosini, Silvia Ceragioli, Fulvio Uggeri, Luciano Lattuada, Roberta Fretta, Aurelia Ferrigato
-
Publication number: 20170210692Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: ApplicationFiled: June 10, 2015Publication date: July 27, 2017Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
-
Publication number: 20170190719Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.Type: ApplicationFiled: July 20, 2015Publication date: July 6, 2017Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta MAZZON, Roberta FRETTA, Pier Lucio ANELLI
-
Publication number: 20160228583Abstract: The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.Type: ApplicationFiled: April 15, 2016Publication date: August 11, 2016Applicant: BRACCO IMAGING S.p.A.Inventors: Pier Lucio ANELLI, Pierfrancesco MOROSINI, Silvia CERAGIOLI, Fulvio UGGERI, Luciano LATTUADA, Roberta FRETTA, Aurelia FERRIGATO