Abstract: The invention features methods, devices, pharmaceutical compositions, and kits for treating or preventing acute vascular leak. Such methods may involve contacting an effective amount of bosutinib for treating or preventing acute vascular leak with a subject in need thereof. Conditions associated with acute vascular leak include ischemic brain injury, stroke, septic shock, anthrax lethal toxin, anaphylaxis, trauma, severe episodic vasculitis, acute lung injury, ventilator-induced lung injury, transfusion-related acute lung injury, acute respiratory distress syndrome, severe burn injury, circulatory shock, capillary leak syndrome, and ischemia-reperfusion injury. The invention also features automatic injection devices, resuscitation fluids, or pharmaceutical compositions comprising an effective amount of bosutinib for treating or preventing acute vascular leak. The invention further features kits for use in the methods of the invention.