Patents by Inventor Roberta Pireddu

Roberta Pireddu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rho kinase inhibitors and methods of use
    Patent number: 9616064
    Abstract: The subject invention concerns materials and methods for treating diseases and disorders associated with expression of Rho associated kinases (ROCKs). Examples of diseases and disorders contemplated within the scope of the invention include, but are not limited to, oncological disorders, cardiovascular diseases, CNS disorders, and inflammatory disorders. In one embodiment, a method of the invention comprises administering a therapeutically effective amount of one or more compounds of the present invention, or a composition comprising the compounds, to a person or animal in need of treatment. The subject invention also concerns compounds that inhibit ROCKs, and compositions that comprise the inhibitor compounds of the invention. Compounds contemplated within the scope of the invention include, but are not limited to, those compounds shown in Table 5.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 11, 2017
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Nicholas J. Lawrence, Said M. Sebti, Roberta Pireddu
  • Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use
    Patent number: 9221808
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: December 29, 2015
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Nicholas J. Lawrence, Roberta Pireddu, Said M. Sebti
  • NOVEL RHO KINASE INHIBITORS AND METHODS OF USE
    Publication number: 20140179689
    Abstract: The subject invention concerns materials and methods for treating diseases and disorders associated with expression of Rho associated kinases (ROCKs). Examples of diseases and disorders contemplated within the scope of the invention include, but are not limited to, oncological disorders, cardiovascular diseases, CNS disorders, and inflammatory disorders. In one embodiment, a method of the invention comprises administering a therapeutically effective amount of one or more compounds of the present invention, or a composition comprising the compounds, to a person or animal in need of treatment. The subject invention also concerns compounds that inhibit ROCKs, and compositions that comprise the inhibitor compounds of the invention. Compounds contemplated within the scope of the invention include, but are not limited to, those compounds shown in Table 5.
    Type: Application
    Filed: March 30, 2012
    Publication date: June 26, 2014
    Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Nicholas J. Lawrence, Said M. Sebti, ROBERTA PIREDDU
  • PYRIDYLTHIAZOLE-BASED UREAS AS INHIBITORS OF RHO ASSOCIATED PROTEIN KINASE (ROCK) AND METHODS OF USE
    Publication number: 20130059839
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Application
    Filed: April 18, 2011
    Publication date: March 7, 2013
    Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Nicholas J. Lawrence, Roberta Pireddu, Said M. Sebti