Patents by Inventor Robert A. Singer

Robert A. Singer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds
    Patent number: 7186870
    Abstract: The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R3, R4, and R5 are defined herein. Compounds of formulae (Ia), (Ib) and (Ic) or mixtures thereof are useful in the preparation of compounds of formula (II): wherein R2, R3 and R6 are also defined herein.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: March 6, 2007
    Assignee: Pfizer Inc
    Inventors: Robert A. Singer, Jason D. Mckinley
  • Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds
    Patent number: 7091372
    Abstract: The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R3, R4, and R5 are defined herein. Compounds of formulae (Ia), (Ib) and (Ic) or mixtures thereof are useful in the preparation of compounds of formula (II): wherein R2, R3 and R6 are also defined herein.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: August 15, 2006
    Assignee: Pfizer Inc
    Inventors: Robert A. Singer, Jason D. McKinley
  • Process for preparing haloalkyl pyrimidines
    Publication number: 20040063938
    Abstract: The invention is a process for producing haloalkyl pyrimidines as intermediates in the production of benzimidazole and/or pyridylimidazole derivatives having high selectivity and/or high affinity to the benzodiazepine site of GABAA receptors.
    Type: Application
    Filed: June 10, 2003
    Publication date: April 1, 2004
    Applicant: Pfizer Inc
    Inventors: Stephane Caron, Nga M. Do, Ruth E. McDermott, Robert A. Singer
  • Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic componunds
    Publication number: 20030060624
    Abstract: The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: 1
    Type: Application
    Filed: April 17, 2002
    Publication date: March 27, 2003
    Inventor: Robert A. Singer
  • Arylamine synthesis
    Patent number: 6323366
    Abstract: The present invention provides a method for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated aryl group and an imine group are combined, in the presence of a transition metal catalyst, under conditions wherein the transition metal catalyst catalyzes the formation of a carbon-nitrogen bond between the activated carbon of the arene and the imine nitrogen; and 2) the resulting N-aryl imine is transformed, via any of a number of standard protocols, to the primary arylamine. The method of the invention may also be exploited in the preparation of vinylamines.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: November 27, 2001
    Assignee: Massachusetts Institute of Technology
    Inventors: John P. Wolfe, Jens Ahman, Joseph P. Sadighi, Robert A. Singer, Stephen L. Buchwald
  • Synthesis of oligoarylamines, and uses and reagents related thereto
    Patent number: 6235871
    Abstract: The transition metal-catalyzed amination of aryl halides, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. The oligoaniline precursors are soluble in a variety of common organic solvents, and are easily converted to the deprotected oligoanilines. The method allows the preparation of oligoanilines of even or odd chain lengths, and the incorporation of a variety of functional groups into the oligomers. Polyanilines of low polydispersity can also be prepared by this method.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: May 22, 2001
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert A. Singer, Joseph P. Sadighi, Stephen L. Buchwald, Thomas Mackewitz
  • Catalysts for production of .beta.-hydroxy carbonyl compounds
    Patent number: 5599963
    Abstract: The invention relates to catalysts for the synthesis of .beta.-hydroxy carbonyl compounds, and in particular to enantioselective catalysts.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: February 4, 1997
    Assignee: California Institute of Technology
    Inventors: Erick M. Carreira, Robert A. Singer