Patent number: 5182265
Abstract: Peptide derivatives and their salts with pharmaceutically acceptable acids or bases, having the general formula (I), ##STR1## wherein R=--H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 acyl, alkoxycarbonyl with C.sub.1 -C.sub.4 alkyl;R.sub.1 =--H, C.sub.1 -C.sub.3 alkyl;R.sub.2 =--H, --OH, --OR'.sub.2, wherein R'.sub.2 =C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 acyl, benzyl;R.sub.3 =--H, --CH.sub.3 ;n=1,2R.sub.4 =--H, --COOH, --CONH.sub.2, --COOR'.sub.4, wherein R'.sub.4 =C.sub.1 -C.sub.3 alkyl, benzyl;R.sub.5 =--H, 4--OH, 3,4--OH, --OR'.sub.5 wherein R'.sub.5 =C.sub.1 -3 alkyl, C.sub.1 -C.sub.3 acyl, benzyl;R.sub.6 =--OH, --NH.sub.2, --OR'.sub.6 wherein R'.sub.6 =C.sub.1 -C.sub.3 alkyl, benzyl; endowed with analgesic, antiviral, immuno-modulating pharmacological properties, and the pharmaceutical forms containing them as active ingredients.
Type:
Grant
Filed:
August 3, 1990
Date of Patent:
January 26, 1993
Assignee:
SPA Societa' Prodotti Antibiotici S.p.A.
Inventors:
Tiberio Bruzzese, Massimo Signorini, Carlo A. Fanciano, Roberta Termini