Patents by Inventor Roberto A. Maldonado

Roberto A. Maldonado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOSING COMBINATIONS FOR REDUCING UNDESIRED HUMORAL IMMUNE RESPONSES
    Publication number: 20140328923
    Abstract: Disclosed are dosings of therapeutic macromolecules and immunosuppressants, in some embodiments attached to synthetic nanocarriers, in combination with dosings of therapeutic macromolecules without synthetic nanocarriers, and related methods that provide reduced humoral immune responses.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • TOLEROGENIC SYNTHETIC NANOCARRIERS AND THERAPEUTIC MACROMOLECULES FOR REDUCED OR ENHANCED PHARMACODYNAMIC EFFECTS
    Publication number: 20140328854
    Abstract: Disclosed are compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules. The effects may result from reduced doses of therapeutic macromolecules in combination with immunosuppressant doses. The effects may also be enhanced with such compositions.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE OR PREVENT ANAPHYLAXIS IN RESPONSE TO A NON-ALLERGENIC ANTIGEN
    Publication number: 20140328921
    Abstract: This invention relates to methods for reducing or preventing anaphylaxis to non-allergenic antigens with compositions comprising immunosuppressants, and related compositions.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • TOLEROGENIC SYNTHETIC NANOCARRIERS FOR INDUCING REGULATORY B CELLS
    Publication number: 20140199340
    Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
    Type: Application
    Filed: January 22, 2014
    Publication date: July 17, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • Tolerogenic synthetic nanocarriers for inducing regulatory B cells
    Patent number: 8652487
    Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 18, 2014
    Assignee: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • INDUCED DENDRITIC CELL COMPOSITIONS AND USES THEREOF
    Publication number: 20130195919
    Abstract: The invention provides, for example, compositions comprising induced tolerogenic dendritic cells which are capable of suppressing an antigen specific T cell-mediated immune response, and to methods of making and using the same. The invention also provides compositions comprising induced immunogenic dendritic cells and methods of making and using them.
    Type: Application
    Filed: March 7, 2011
    Publication date: August 1, 2013
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Ulrich Von Andrian, Roberto Maldonado, Fulvia Vascotto
  • COMPOSITIONS AND METHODS RELATED TO INDUCED TOLEROGENIC DENDRITIC CELLS EXTERNALLY LOADED WITH MHC CLASS I-RESTRICTED EPITOPES
    Publication number: 20130058977
    Abstract: Disclosed are induced tolerogenic dendritic cells (itDCs) produced by combining itDCs with externally loadable MHC Class I-restricted epitopes, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • ANTIGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS TO REDUCE ANTIBODY RESPONSES
    Publication number: 20130058975
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) for reducing undesired humoral immune responses, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • TRANSPLANTABLE GRAFT-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS AND METHODS OF USE
    Publication number: 20130058901
    Abstract: Disclosed are transplantable graft-specific induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • INDUCED TOLEROGENIC DENDRITIC CELLS FOR INDUCING REGULATORY B CELLS
    Publication number: 20130058978
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that generate regulatory B cells, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventor: Roberto A. Maldonado
  • ANTIGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS TO REDUCE CYTOTOXIC T LYMPHOCYTE RESPONSES
    Publication number: 20130058974
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) for reducing CD8+ T cell immune responses, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • ALLERGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS FOR ALLERGY THERAPY
    Publication number: 20130058976
    Abstract: Disclosed are allergen-specific induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado
  • THERAPEUTIC PROTEIN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS AND METHODS OF USE
    Publication number: 20130058894
    Abstract: Disclosed are therapeutic protein-specific induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • INDUCED TOLEROGENIC DENDRITIC CELLS FOR GENERATING CD8+ REGULATORY T CELLS
    Publication number: 20130058963
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that generate CD8+ regulatory T cells, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Roberto A. Maldonado, Takashi Kei Kishimoto
  • DENDRITIC CELL SUBSETS FOR GENERATING INDUCED TOLEROGENIC DENDRITIC CELLS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20130058902
    Abstract: Disclosed are induced tolerogenic dendritic cells (itDCs) produced from dendritic cell subsets that possess a desired physiological characteristic, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado
  • INDUCED TOLEROGENIC DENDRITIC CELLS TO REDUCE SYSTEMIC INFLAMMATORY CYTOKINES
    Publication number: 20130058970
    Abstract: Disclosed are induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods, for reducing systemic inflammatory cytokines.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado
  • COMPOSITIONS AND METHODS FOR PRODUCING ANTIGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS WITH SYNTHETIC NANOCARRIERS
    Publication number: 20130059009
    Abstract: Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that are produced from combining itDCs with antigen in particulate form, as well as related compositions and methods.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Roberto A. Maldonado, Christopher Fraser, David H. Altreuter
  • CONTROLLED RELEASE OF IMMUNOSUPPRESSANTS FROM SYNTHETIC NANOCARRIERS
    Publication number: 20120301498
    Abstract: Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods. The synthetic nanocarrier compositions may also include antigen in some embodiments.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 29, 2012
    Applicant: Selecta Biosciences, Inc.
    Inventors: David H. Altreuter, Aaron P. Griset, Roberto A. Maldonado
  • TOLEROGENIC SYNTHETIC NANOCARRIERS COUPLED TO CD1D-RESTRICTED ANTIGENS AND METHODS OF USE
    Publication number: 20120301510
    Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising CD1d-restricted antigens and immunosuppressants that provide tolerogenic immune responses.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 29, 2012
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Christopher Fraser, Roberto A. Maldonado
  • TOLEROGENIC SYNTHETIC NANOCARRIERS FOR ALLERGY THERAPY
    Publication number: 20120294888
    Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 22, 2012
    Applicant: Selecta Biosciences, Inc.
    Inventors: Takashi Kei Kishimoto, Christopher Fraser, Roberto A. Maldonado