Patents by Inventor Roberto Bortolaso

Roberto Bortolaso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing the cyclohexylamine salt of (+) - threo-2-hydroxy-3-(2'-aminophenylthio) -3-(4"-methoxyphenyl) -propionic acid and of its (-) -antipode"
    Patent number: 5710321
    Abstract: The present invention relates to a process for preparing the cyclohexylamine salt of (+)-threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid and of its optical (-)-antipode, by starting from the racemate acid by means of a first crystallization from a suitable chiral base and a second crystallization from a cyclohexylamine-containing solvent. Said salt is an intermediate in the synthesis of diltiazem, a well-known calcium-antagonist drug.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: January 20, 1998
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Roberto Bortolaso, Siro Serafini
  • Process for preparing [R-(R*,R*)]-5-(3-chlorophenyl)-3-[2-(3,4-dimethoxylphenyl)-1-methyl-ethy l]-oxazolidin-2-one
    Patent number: 5663360
    Abstract: The present invention relates to a process for preparing [R-(R*,R*)]-5-(3-chlorophenyl)-3-[2-(3,4-dimethoxyphenyl)-1-methyl-ethyl]- oxazolidin-2-one of Formula (1), characterized in that said process comprises the step of reacting (R)-3, 4-methoxy-amphetamine of Formula (3), with (R)-3-chloro-mandelic acid, of Formula (9): ##STR1##
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: September 2, 1997
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Roberto Bortolaso, Mariano Stivanello