Abstract: When estimating respiratory muscle pressure and respiratory mechanics using a P0.1 maneuver patient inspiration onset for a patient connected to a ventilator (64) is detected, and the airway of the patient is occluded for a first predetermined time period. A first respiratory muscle pressure (Pmus) profile is estimated during the airway occlusion. Resistance (R) and compliance (C) values and a second Pmus profile generated during a second predetermined time period are then estimated. A third Pmus profile is estimated during a third predetermined time period that extends from the end of the second predetermined time period until the end of inspiration. Pmus(t) over an entire breath is estimated by concatenating the first, second and third Pmus profiles, and the estimated R and C values and the estimated Pmus profiles are output on a display.

Abstract: A mechanical ventilator (10) is connected with a ventilated patient (12) to provide ventilation in accordance with ventilator settings of the mechanical ventilator. Physiological values (variables) are acquired for the ventilated patient using physiological sensors (32). A ventilated patient cardiopulmonary (CP) model (40) is fitted to the acquired physiological variables values to generate a fitted ventilated patient CP model by fine-tuning its parameters (50). Updated ventilator settings are determined by adjusting model ventilator settings of the fitted ventilated patient CP model to minimize a cost function (60). The updated ventilator settings may be displayed on a display component (22) as recommended ventilator settings for the ventilated patient, or the ventilator settings of the mechanical ventilator may be automatically changed to the updated ventilator settings so as to automatically control the mechanical ventilator.