Patents by Inventor Roberto Carlos Bravo Gonzalez
Roberto Carlos Bravo Gonzalez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10272048Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralized, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.Type: GrantFiled: September 16, 2016Date of Patent: April 30, 2019Assignee: Tillotts Pharma AGInventors: Felipe Josè Oliveira Varum, Roberto Carlos Bravo González, Thomas Buser, Abdul Waseh Basit, Ana Cristina Freire
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Patent number: 10226430Abstract: Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralized polycarboxylic acid and a non-ionic polymer. In embodiments in which the third polymeric material is a non-ionic polymer, the inner layer comprises at least one of a buffer agent and a base.Type: GrantFiled: April 29, 2013Date of Patent: March 12, 2019Assignee: TILLOTTS PHARMA AGInventors: Roberto Carlos Bravo Gonzalez, Thomas Buser, Frederic Jean-Claude Goutte, Abdul Waseh Basit, Felipe Jose Oliveira Varum, Ana Cristina Freire
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Patent number: 10179105Abstract: The present invention relates to microgel particles containing nanotubes loaded with an active pharmaceutical ingredient, a process for their preparation and a pharmaceutical composition comprising the same.Type: GrantFiled: March 21, 2016Date of Patent: January 15, 2019Assignee: Tillotts Pharma AGInventors: Jan Kendall De Kruif, Carla Garofalo, Gisela Ledergerber, Martin Kuentz, Roberto Carlos Bravo Gonzaléz, Felipe José Oliveira Varum
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Publication number: 20180125784Abstract: The present invention relates to a delayed release pharmaceutical formulation for delivering an active agent to the intestine, a method of preparing such formulation and the use of such formulation in the treatment of gastrointestinal disorders.Type: ApplicationFiled: January 9, 2018Publication date: May 10, 2018Applicant: Tillotts Pharma AGInventors: Daniel Preisig, Maxim Puchkov, Joerg Huwyler, Felipe José Oliveira Varum, Roberto Carlos Bravo Gonzalez
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Publication number: 20180049980Abstract: The present invention relates to microgel particles, a process for their preparation and a pharmaceutical composition comprising the same.Type: ApplicationFiled: March 21, 2016Publication date: February 22, 2018Applicant: Tillotts Pharma AGInventors: Jan Kendall DE KRUIF, Carla GAROFALO, Gisela LEDERGERBER, Martin KUENTZ, Roberto Carlos BRAVO GONZALÉZ, Felipe José OLIVEIRA VARUM
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Patent number: 9895314Abstract: The present invention relates to a delayed release pharmaceutical formulation for delivering an active agent to the intestine, a method of preparing such formulation and the use of such formulation in the treatment of gastrointestinal disorders, wherein the formulation includes at least one active agent associated with porous, functionalized calcium carbonate carrier particles that are surrounded by a material for colon targeting.Type: GrantFiled: September 22, 2014Date of Patent: February 20, 2018Assignee: Tillotts Pharma AGInventors: Daniel Preisig, Maxim Puchkov, Joerg Huwyler, Felipe José Oliveira Varum, Roberto Carlos Bravo Gonzalez
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Patent number: 9814681Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.Type: GrantFiled: October 29, 2013Date of Patent: November 14, 2017Assignee: Tillotts Pharma AGInventors: Felipe José Oliveira Varum, Roberto Carlos Bravo González, Thomas Buser
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Publication number: 20170266117Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.Type: ApplicationFiled: June 2, 2017Publication date: September 21, 2017Applicant: Tillotts Phharma AGInventors: Felipe Josè OLIVEIRA VARUM, Roberto Carlos BRAVO GONZÁLEZ, Thomas BUSER, Abdul Waseh BASIT, Ana Cristina FREIRE
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Publication number: 20170119681Abstract: The present invention relates to a modified release coated capsule and a process to obtain that capsule.Type: ApplicationFiled: May 13, 2015Publication date: May 4, 2017Applicant: TILLOTTS PHARMA AGInventors: Roberto Carlos BRAVO GONZALÉZ, Felipe José OLIVEIRA VARUM, Thomas BUSER
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Publication number: 20170079927Abstract: The present invention relates to a modified release coated capsule and a process to obtain that capsule.Type: ApplicationFiled: May 13, 2015Publication date: March 23, 2017Applicant: Tillotts Pharma AGInventors: Roberto Carlos BRAVO GONZALÉZ, Felipe José OLIVEIRA VARUM, Thomas BUSER
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Publication number: 20170035698Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.Type: ApplicationFiled: September 16, 2016Publication date: February 9, 2017Applicant: Tillotts Pharma AGInventors: Felipe Josè OLIVEIRA VARUM, Roberto Carlos BRAVO GONZÁLEZ, Thomas BUSER, Abdul Waseh BASIT, Ana Cristina FREIRE
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Publication number: 20160287521Abstract: The present invention relates to a multi-particulate drug delivery system, a process for its preparation and capsules being filled with such system.Type: ApplicationFiled: November 13, 2014Publication date: October 6, 2016Applicant: Tillotts Pharma AGInventors: Roberto Carlos BRAVO GONZALÉZ, Felipe José Oliveira VARUM, Jan Kendall DE KRUIF, Martin KUENTZ
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Publication number: 20160250232Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.Type: ApplicationFiled: October 29, 2013Publication date: September 1, 2016Applicant: TILLOTTS PHARMA AGInventors: Felipe Jose Oliveira VARUM, Roberto Carlos BRAVO GONZALEZ, Thomas BUSER, Abdul Waseh BASIT, Ana Cristina FREIRE
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Publication number: 20160235673Abstract: The present invention relates to a delayed release pharmaceutical formulation for delivering an active agent to the intestine, a method of preparing such formulation and the use of such formulation in the treatment of gastrointestinal disorders.Type: ApplicationFiled: September 22, 2014Publication date: August 18, 2016Applicant: TILLOTTS PHARMA AGInventors: Daniel PREISIG, Maxim PUCHKOV, Joerg HUWYLER, Felipe José OLIVEIRA VARUM, Roberto Carlos BRAVO GONZALEZ
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Patent number: 9364440Abstract: Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an outer layer and at least one layer between the core and the outer layer selected from the group consisting of an isolation layer and an inner layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralised polycarboxylic acid and a non-ionic polymer. In embodiments in which the third polymeric material is a non-ionic polymer, the inner layer comprises at least one of a buffer agent and a base.Type: GrantFiled: April 29, 2013Date of Patent: June 14, 2016Assignee: TILLOTTS PHARMA AGInventors: Roberto Carlos Bravo Gonzalez, Thomas Buser, Frederic Jean-Claude Goutte, Abdul Waseh Basit, Felipe Jose Oliveira Varum, Ana Cristina Freire
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Publication number: 20150132380Abstract: Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an outer layer and at least one layer between the core and the outer layer selected from the group consisting of an isolation layer and an inner layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralised polycarboxylic acid and a non-ionic polymer. In embodiments in which the third polymeric material is a non-ionic polymer, the inner layer comprises at least one of a buffer agent and a base.Type: ApplicationFiled: April 29, 2013Publication date: May 14, 2015Applicant: TILLOTTS PHARMA AGInventors: Roberto Carlos Bravo Gonzalez, Thomas Buser, Frederic Jean-Claude Goutte, Abdul Waseh Basit, Felipe Jose Oliveira Varum, Ana Cristina Freire
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Publication number: 20150125525Abstract: Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralised polycarboxylic acid and a non-ionic polymer. In embodiments in which the third polymeric material is a non-ionic polymer, the inner layer comprises at least one of a buffer agent and a base.Type: ApplicationFiled: April 29, 2013Publication date: May 7, 2015Applicant: TILLOTTS PHARMA AGInventors: Roberto Carlos Bravo Gonzalez, Thomas Buser, Frederic Goutte, Abdul Waseh Basit, Felipe Jose, Oliveira Varum, Ana Cristina Freire
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Publication number: 20140056980Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.Type: ApplicationFiled: October 29, 2013Publication date: February 27, 2014Applicant: Tillotts Pharma AGInventors: Felipe José OLIVEIRA VARUM, Roberto Carlos Bravo González, Thomas Buser