Patents by Inventor Roberto Chicharro Martin

Roberto Chicharro Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCEDURE FOR OBTAINING GADOTERATE MEGLUMINE FROM HIGH-PURITY TETRAXETAN (DOTA) AND ITS USE IN THE PREPARATION OF INJECTABLE GALENICAL FORMULATIONS
    Publication number: 20230248851
    Abstract: The present invention refers to a process for obtaining gadoterate meglumine from high purity tetraxetan (DOTA) which does not require the use of organic solvents and optimizes the conditions of the synthetic process. The tetraxetan from which the gadoterate meglumine is obtained by a synthetic process that includes a purification step in which at least one electrodialysis is performed. This procedure makes it possible to obtain a tetraxetan and a gadoterate meglumine with minimal amounts of impurities.
    Type: Application
    Filed: June 10, 2021
    Publication date: August 10, 2023
    Inventors: Ignacio ALONSO SILVA, Juan Andrés CERECEDA PÉREZ, Felix Ramón MARTÍN MARTÍN, Maria Ángeles REGUEIRA GÓMEZ, Roberto CHICHARRO MARTÍN, ÁIvaro GARCÍA RAMOS, Irene GARCÍA SALADO, Vicente MONTIEL LEGUEY, Eduardo EXPÓSITO RODRÍGUEZ, Vicente GARCÍA GARCÍA, David VALERO VALERO, Alfonso SÁEZ FÉRNANDEZ, Francisco GALLUD MARTINÉZ
  • Isoquinoline derivatives as calpain inhibitors
    Patent number: 7932266
    Abstract: The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec-butyl group at position 3 with calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3-sec-butyl-1-oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid and (3-sec-butyl-1-thioxo-2, 3-dihydro-1H-isoquinolin-4-yliden)-acetic acid. Compounds having formula I or II can be used in the preventive or therapeutic treatment of a degenerative disease.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: April 26, 2011
    Assignee: Consejo Superior de Investigaciones Cientificas
    Inventors: Bernardo Herradon García, Roberto Chicharro Martin, Vicente Jesús Aran Redo, Mercedes Alonso Giner
  • Isoquinoline Derivatives as Calpain Inhibitors
    Publication number: 20080090862
    Abstract: The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec-butyl group at position 3 with calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3-sec-butyl-1-oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid and (3-sec-butyl-1-thioxo-2, 3-dihydro-1H-isoquinolin-4-yliden)-acetic acid. Compounds having formula I or II can be used in the preventive or therapeutic treatment of a degenerative disease.
    Type: Application
    Filed: December 5, 2005
    Publication date: April 17, 2008
    Inventors: Bernado Garcia, Roberto Chicharro Martin, Vicente Aran Redo, Mercedes Alonso Giner